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Aliases for C3orf49 Gene

Aliases for C3orf49 Gene

  • Chromosome 3 Open Reading Frame 49 2 3 5

External Ids for C3orf49 Gene

Previous GeneCards Identifiers for C3orf49 Gene

  • GC03P063782

Summaries for C3orf49 Gene

GeneCards Summary for C3orf49 Gene

C3orf49 (Chromosome 3 Open Reading Frame 49) is a Protein Coding gene.

Additional gene information for C3orf49 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf49 Gene

Genomics for C3orf49 Gene

GeneHancer (GH) Regulatory Elements for C3orf49 Gene

Promoters and enhancers for C3orf49 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I064143 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.7 +324.6 324640 1.8 MEIS2 PKNOX1 ZNF449 ZNF529 MZF1 ZNF384 FEZF1 ZNF213 ZNF366 POLR2A LOC100130345 C3orf49 PRDX3P4 PRICKLE2-AS2 PRICKLE2
GH03I063351 Enhancer 0.7 ENCODE 11.5 -468.0 -468012 0.1 CTCF ESRRA SUZ12 NEUROD1 SIN3A NFXL1 YBX1 FEZF1 RAD21 CTBP1 C3orf49 GC03M063421 UBL5P3 SYNPR
GH03I063823 Enhancer 0.4 ENCODE 0.4 +5.2 5238 1.3 ZSCAN4 FOSL2 FOS ATXN7 THOC7 THOC7-AS1 LOC100130345 C3orf49
GH03I063846 Enhancer 0.3 ENCODE 0.3 +28.8 28805 3 SP1 LOC100130345 THOC7-AS1 THOC7 C3orf49
GH03I063845 Enhancer 0.2 ENCODE 0.3 +26.2 26236 0.8 THOC7 LOC100130345 THOC7-AS1 C3orf49
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C3orf49 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C3orf49 gene promoter:

Genomic Locations for C3orf49 Gene

Genomic Locations for C3orf49 Gene
29,275 bases
Plus strand

Genomic View for C3orf49 Gene

Genes around C3orf49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf49 Gene

Proteins for C3orf49 Gene

  • Protein details for C3orf49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative uncharacterized protein C3orf49
    Protein Accession:

    Protein attributes for C3orf49 Gene

    292 amino acids
    Molecular mass:
    33461 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C3orf49 Gene

Post-translational modifications for C3orf49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C3orf49 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C3orf49 Gene

Domains & Families for C3orf49 Gene

Gene Families for C3orf49 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C3orf49 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf49: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C3orf49 Gene

Function for C3orf49 Gene

Phenotypes From GWAS Catalog for C3orf49 Gene

Phenotypes for C3orf49 Gene

GenomeRNAi human phenotypes for C3orf49:
genes like me logo Genes that share phenotypes with C3orf49: view

miRNA for C3orf49 Gene

miRTarBase miRNAs that target C3orf49

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf49 Gene

Localization for C3orf49 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf49 gene
Compartment Confidence
nucleus 3
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C3orf49 Gene

Pathways & Interactions for C3orf49 Gene

SuperPathways for C3orf49 Gene

No Data Available

Interacting Proteins for C3orf49 Gene

Gene Ontology (GO) - Biological Process for C3orf49 Gene


No data available for Pathways by source and SIGNOR curated interactions for C3orf49 Gene

Drugs & Compounds for C3orf49 Gene

No Compound Related Data Available

Transcripts for C3orf49 Gene

mRNA/cDNA for C3orf49 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C3orf49 Gene

Chromosome 3 open reading frame 49:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf49 Gene

No ASD Table

Relevant External Links for C3orf49 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C3orf49 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf49 Gene

mRNA differential expression in normal tissues according to GTEx for C3orf49 Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for C3orf49 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C3orf49 Gene

Protein tissue co-expression partners for C3orf49 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C3orf49 Gene:


SOURCE GeneReport for Unigene cluster for C3orf49 Gene:

genes like me logo Genes that share expression patterns with C3orf49: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf49 Gene

Orthologs for C3orf49 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C3orf49 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C3orf49 34
  • 99 (a)
(Canis familiaris)
Mammalia C3orf49 34
  • 79 (a)
(Bos Taurus)
Mammalia C3orf49 34
  • 74 (a)
(Monodelphis domestica)
Mammalia C3orf49 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia C3orf49 34
  • 67 (a)
Species where no ortholog for C3orf49 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C3orf49 Gene

Gene Tree for C3orf49 (if available)
Gene Tree for C3orf49 (if available)

Paralogs for C3orf49 Gene Pseudogenes for C3orf49 Gene

genes like me logo Genes that share paralogs with C3orf49: view

No data available for Paralogs for C3orf49 Gene

Variants for C3orf49 Gene

Sequence variations from dbSNP and Humsavar for C3orf49 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000074512 -- 63,835,748(+) A/C intron_variant
rs1000120340 -- 63,848,844(+) T/C downstream_transcript_variant
rs1000126641 -- 63,836,040(+) T/G intron_variant
rs1000161965 -- 63,830,784(+) CTTACT/CT intron_variant
rs1000183844 -- 63,822,255(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf49 Gene

Variant ID Type Subtype PubMed ID
nsv1008751 CNV gain 25217958
nsv478119 CNV novel sequence insertion 20440878

Variation tolerance for C3orf49 Gene

Gene Damage Index Score: 7.14; 80.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C3orf49 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf49 Gene

Disorders for C3orf49 Gene

Additional Disease Information for C3orf49

No disorders were found for C3orf49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf49 Gene

Publications for C3orf49 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
  4. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PMID: 24023788) Ong BA … Hakonarson H (PloS one 2013) 3 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58

Products for C3orf49 Gene

Sources for C3orf49 Gene

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