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Aliases for C3orf38 Gene

Aliases for C3orf38 Gene

  • Chromosome 3 Open Reading Frame 38 2 3 5

External Ids for C3orf38 Gene

Previous GeneCards Identifiers for C3orf38 Gene

  • GC03P088282
  • GC03P088198

Summaries for C3orf38 Gene

GeneCards Summary for C3orf38 Gene

C3orf38 (Chromosome 3 Open Reading Frame 38) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C3orf38 Gene

  • May be involved in apoptosis regulation.

Additional gene information for C3orf38 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf38 Gene

Genomics for C3orf38 Gene

GeneHancer (GH) Regulatory Elements for C3orf38 Gene

Promoters and enhancers for C3orf38 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I088148 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 411 3.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CGGBP1 C3orf38 ZNF654 GC03P088161 GC03P088045
GH03I088057 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.2 -90.7 -90656 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF213 CGGBP1 ZNF654 C3orf38 GC03P088045
GH03I088113 Enhancer 0.5 ENCODE 11.9 -36.0 -35977 0.2 CTCF JUND ZNF654 TRIM22 ZNF143 RAD21 CGGBP1 C3orf38 ZNF654 GC03P088128 CBX5P1 GC03P088045
GH03I088038 Enhancer 0.2 ENCODE 11 -111.0 -110957 0.2 CGGBP1 C3orf38 GC03P088045 GC03P088032
GH03I088030 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -119.3 -119290 0.7 ZNF507 YY1 CGGBP1 ZNF654 C3orf38 GC03P088032 RNU6ATAC6P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C3orf38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C3orf38 gene promoter:

Genomic Locations for C3orf38 Gene

Genomic Locations for C3orf38 Gene
18,987 bases
Plus strand

Genomic View for C3orf38 Gene

Genes around C3orf38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf38 Gene

Proteins for C3orf38 Gene

  • Protein details for C3orf38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C3orf38
    Protein Accession:
    Secondary Accessions:
    • B2R8X6
    • Q8TC85

    Protein attributes for C3orf38 Gene

    329 amino acids
    Molecular mass:
    37541 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf38 Gene


neXtProt entry for C3orf38 Gene

Post-translational modifications for C3orf38 Gene

  • Ubiquitination at posLast=318318
  • Modification sites at PhosphoSitePlus

Other Protein References for C3orf38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C3orf38 Gene

Domains & Families for C3orf38 Gene

Gene Families for C3orf38 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C3orf38 Gene

Suggested Antigen Peptide Sequences for C3orf38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf38: view

No data available for UniProtKB/Swiss-Prot for C3orf38 Gene

Function for C3orf38 Gene

Molecular function for C3orf38 Gene

UniProtKB/Swiss-Prot Function:
May be involved in apoptosis regulation.

Phenotypes From GWAS Catalog for C3orf38 Gene

Gene Ontology (GO) - Molecular Function for C3orf38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C3orf38: view
genes like me logo Genes that share phenotypes with C3orf38: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf38 Gene

Localization for C3orf38 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf38 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C3orf38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17464193
genes like me logo Genes that share ontologies with C3orf38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C3orf38 Gene

Pathways & Interactions for C3orf38 Gene

SuperPathways for C3orf38 Gene

No Data Available

Interacting Proteins for C3orf38 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000322469 Q5JPI3-CC038_HUMAN for C3orf38 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C3orf38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043065 positive regulation of apoptotic process IDA 17464193
genes like me logo Genes that share ontologies with C3orf38: view

No data available for Pathways by source and SIGNOR curated interactions for C3orf38 Gene

Drugs & Compounds for C3orf38 Gene

No Compound Related Data Available

Transcripts for C3orf38 Gene

Unigene Clusters for C3orf38 Gene

Chromosome 3 open reading frame 38:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf38 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: -

Relevant External Links for C3orf38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C3orf38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf38 Gene

Protein differential expression in normal tissues from HIPED for C3orf38 Gene

This gene is overexpressed in Fetal ovary (41.7) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C3orf38 Gene

Protein tissue co-expression partners for C3orf38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C3orf38 Gene:


SOURCE GeneReport for Unigene cluster for C3orf38 Gene:


Evidence on tissue expression from TISSUES for C3orf38 Gene

  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with C3orf38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf38 Gene

Orthologs for C3orf38 Gene

This gene was present in the common ancestor of animals.

Orthologs for C3orf38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C3orf38 34
  • 100 (a)
C3H3orf38 33
  • 99.59 (n)
(Canis familiaris)
Mammalia C33H3orf38 33
  • 89.57 (n)
C3orf38 34
  • 84 (a)
(Bos Taurus)
Mammalia C1H3orf38 33
  • 88.96 (n)
C3orf38 34
  • 85 (a)
(Mus musculus)
Mammalia 4930453N24Rik 33 16 34
  • 85.99 (n)
(Ornithorhynchus anatinus)
Mammalia C3orf38 34
  • 62 (a)
(Monodelphis domestica)
Mammalia C3orf38 34
  • 54 (a)
(Gallus gallus)
Aves C1H3ORF38 33
  • 66.78 (n)
C3orf38 34
  • 54 (a)
(Anolis carolinensis)
Reptilia C3orf38 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf38 33
  • 56.89 (n)
(Danio rerio)
Actinopterygii LOC100330300 33
  • 56.96 (n)
C9H3orf38 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13876 33 34
  • 43.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for C3orf38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf38 Gene

Gene Tree for C3orf38 (if available)
Gene Tree for C3orf38 (if available)

Paralogs for C3orf38 Gene Pseudogenes for C3orf38 Gene

genes like me logo Genes that share paralogs with C3orf38: view

No data available for Paralogs for C3orf38 Gene

Variants for C3orf38 Gene

Sequence variations from dbSNP and Humsavar for C3orf38 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000826514 -- 88,149,424(+) G/A/T upstream_transcript_variant
rs1001532077 -- 88,157,523(+) C/A 3_prime_UTR_variant
rs1001542184 -- 88,157,884(+) A/G 3_prime_UTR_variant
rs1002315140 -- 88,152,590(+) G/A intron_variant
rs1002652148 -- 88,154,207(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf38 Gene

Variant ID Type Subtype PubMed ID
esv3596913 CNV gain 21293372
esv3596915 CNV gain 21293372

Variation tolerance for C3orf38 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C3orf38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf38 Gene

Disorders for C3orf38 Gene

Additional Disease Information for C3orf38

No disorders were found for C3orf38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf38 Gene

Publications for C3orf38 Gene

  1. Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. (PMID: 21177773) Moyer AM … Weinshilboum RM (Toxicological sciences : an official journal of the Society of Toxicology 2011) 3 44 58
  2. Identification of novel regulators of apoptosis using a high-throughput cell-based screen. (PMID: 17464193) Park KM … Kim SJ (Molecules and cells 2007) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C3orf38 Gene

Sources for C3orf38 Gene

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