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Aliases for C3orf33 Gene

Aliases for C3orf33 Gene

  • Chromosome 3 Open Reading Frame 33 2 3 5
  • AP-1 Activity Suppressor 3
  • Protein C3orf33 3
  • Protein AC3-33 4
  • AC3-33 3

External Ids for C3orf33 Gene

Previous GeneCards Identifiers for C3orf33 Gene

  • GC03M156964
  • GC03M155480
  • GC03M152875

Summaries for C3orf33 Gene

GeneCards Summary for C3orf33 Gene

C3orf33 (Chromosome 3 Open Reading Frame 33) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for C3orf33 Gene

  • Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.

Additional gene information for C3orf33 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf33 Gene

Genomics for C3orf33 Gene

GeneHancer (GH) Regulatory Elements for C3orf33 Gene

Promoters and enhancers for C3orf33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J155804 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 659.5 +0.7 654 2.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 C3orf33 PLCH1 SLC33A1 ENSG00000284952 RPL7AP24
GH03J155743 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.7 +60.9 60896 3.6 PKNOX1 FOXA2 ARID4B SIN3A ZNF48 ETS1 GLIS2 MXD4 REST SREBF1 PLCH1 ENSG00000214919 C3orf33 SLC33A1 RPL7AP24
GH03J155869 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.4 -64.9 -64934 3.8 CLOCK ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF766 E2F8 GMPS C3orf33 PLCH1 SETP14
GH03J155851 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5 -47.3 -47258 4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 GMPS SLC33A1 LOC105374174 ENSG00000284952 C3orf33
GH03J155888 Enhancer 1.1 Ensembl ENCODE 6 -83.8 -83809 2.7 PKNOX1 ATF1 FOXA2 ARNT NCOA2 TCF12 ZNF766 GATA2 FOS ATF7 SLC33A1 ENSG00000214919 PLCH1 GMPS C3orf33 SETP14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C3orf33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C3orf33 gene promoter:
  • HNF-1
  • HNF-1A
  • NF-1
  • NF-1/L
  • SRF
  • SRF (504 AA)

Genomic Locations for C3orf33 Gene

Genomic Locations for C3orf33 Gene
chr3:155,762,612-155,806,351
(GRCh38/hg38)
Size:
43,740 bases
Orientation:
Minus strand
chr3:155,480,401-155,524,140
(GRCh37/hg19)
Size:
43,740 bases
Orientation:
Minus strand

Genomic View for C3orf33 Gene

Genes around C3orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf33 Gene

Proteins for C3orf33 Gene

  • Protein details for C3orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1S2-CC033_HUMAN
    Recommended name:
    Protein C3orf33
    Protein Accession:
    Q6P1S2
    Secondary Accessions:
    • A8K1H5
    • Q86YE6
    • Q8IXA7
    • Q96NB5

    Protein attributes for C3orf33 Gene

    Size:
    294 amino acids
    Molecular mass:
    33765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO06952.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C3orf33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf33 Gene

Post-translational modifications for C3orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for C3orf33
  • Boster Bio Antibodies for C3orf33

No data available for DME Specific Peptides for C3orf33 Gene

Domains & Families for C3orf33 Gene

Gene Families for C3orf33 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for C3orf33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C3orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf33: view

No data available for UniProtKB/Swiss-Prot for C3orf33 Gene

Function for C3orf33 Gene

Molecular function for C3orf33 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.
genes like me logo Genes that share phenotypes with C3orf33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C3orf33

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf33 Gene

Localization for C3orf33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf33 Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf33 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20680465
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf33: view

Pathways & Interactions for C3orf33 Gene

SuperPathways for C3orf33 Gene

No Data Available

Interacting Proteins for C3orf33 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000445446%0d%0a9606.ENSP00000313995%0d%0a
Selected Interacting proteins: ENSP00000445446 Q6P1S2-CC033_HUMAN for C3orf33 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051090 regulation of DNA binding transcription factor activity IDA 20680465
GO:0070373 negative regulation of ERK1 and ERK2 cascade IDA 20680465
genes like me logo Genes that share ontologies with C3orf33: view

No data available for Pathways by source and SIGNOR curated interactions for C3orf33 Gene

Drugs & Compounds for C3orf33 Gene

No Compound Related Data Available

Transcripts for C3orf33 Gene

mRNA/cDNA for C3orf33 Gene

Unigene Clusters for C3orf33 Gene

Chromosome 3 open reading frame 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C3orf33

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf33 Gene

No ASD Table

Relevant External Links for C3orf33 Gene

GeneLoc Exon Structure for
C3orf33
ECgene alternative splicing isoforms for
C3orf33

Expression for C3orf33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf33 Gene

Protein differential expression in normal tissues from HIPED for C3orf33 Gene

This gene is overexpressed in Adrenal (21.5), Liver (17.7), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C3orf33 Gene



Protein tissue co-expression partners for C3orf33 Gene

NURSA nuclear receptor signaling pathways regulating expression of C3orf33 Gene:

C3orf33

SOURCE GeneReport for Unigene cluster for C3orf33 Gene:

Hs.350846

mRNA Expression by UniProt/SwissProt for C3orf33 Gene:

Q6P1S2-CC033_HUMAN
Tissue specificity: Highly expressed in ileocecal tissue and endometrium.

Evidence on tissue expression from TISSUES for C3orf33 Gene

  • Heart(4.2)
  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with C3orf33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf33 Gene

Orthologs for C3orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C3orf33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf33 33
  • 99.34 (n)
C3ORF33 34
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C23H3orf33 33
  • 89.07 (n)
C3orf33 34
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H3orf33 33
  • 89.07 (n)
C3orf33 34
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565059 33
  • 81.41 (n)
mouse
(Mus musculus)
Mammalia E130311K13Rik 16 34 33
  • 80.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf33 34
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C3orf33 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves C9H3orf33 33
  • 59.61 (n)
C3orf33 34
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf33 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496931 33
  • 63.05 (n)
zebrafish
(Danio rerio)
Actinopterygii c3orf33 33
  • 50.79 (n)
C18H3orf33 34
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W09H1.3 34
  • 30 (a)
OneToMany
F32A11.1 34
  • 21 (a)
OneToMany
Species where no ortholog for C3orf33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C3orf33 Gene

ENSEMBL:
Gene Tree for C3orf33 (if available)
TreeFam:
Gene Tree for C3orf33 (if available)

Paralogs for C3orf33 Gene

(24) SIMAP similar genes for C3orf33 Gene using alignment to 4 proteins:

  • CC033_HUMAN
  • F8WCI5_HUMAN
  • F8WDI1_HUMAN
  • H7C4I0_HUMAN
genes like me logo Genes that share paralogs with C3orf33: view

No data available for Paralogs for C3orf33 Gene

Variants for C3orf33 Gene

Sequence variations from dbSNP and Humsavar for C3orf33 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000007567 -- 155,797,462(-) T/A/C intron_variant
rs1000237901 -- 155,792,486(-) A/T intron_variant
rs1000288973 -- 155,791,139(-) G/C intron_variant
rs1000394122 -- 155,804,520(-) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000459641 -- 155,793,699(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf33 Gene

Variant ID Type Subtype PubMed ID
dgv1421e212 CNV gain 25503493
dgv4926n100 CNV gain 25217958
dgv4927n100 CNV gain 25217958
dgv4928n100 CNV gain 25217958
dgv8657n54 CNV gain 21841781
esv25006 CNV gain 19812545
esv2759192 CNV gain 17122850
esv2763741 CNV gain 21179565
esv33346 CNV gain 17666407
esv3562765 CNV deletion 23714750
esv3575619 CNV gain 25503493
esv3575620 CNV gain 25503493
esv3598283 CNV loss 21293372
esv3598284 CNV loss 21293372
esv3598285 CNV gain 21293372
esv3893791 CNV loss 25118596
nsv1009618 CNV gain 25217958
nsv1117035 CNV deletion 24896259
nsv1136778 CNV deletion 24896259
nsv441844 CNV gain 18776908
nsv514997 CNV loss 21397061
nsv516712 CNV gain 19592680
nsv592079 CNV gain 21841781
nsv592080 CNV gain 21841781
nsv592081 CNV gain 21841781
nsv818180 CNV gain 17921354
nsv819264 CNV loss 19587683

Variation tolerance for C3orf33 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C3orf33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf33 Gene

Disorders for C3orf33 Gene

Additional Disease Information for C3orf33

No disorders were found for C3orf33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf33 Gene

Publications for C3orf33 Gene

  1. AC3-33, a novel secretory protein, inhibits Elk1 transcriptional activity via ERK pathway. (PMID: 20680465) Hao D … Zhang X (Molecular biology reports 2011) 2 3 4 58
  2. Analysis of AC3-33 gene expression in multiple organ cancer and adjacent normal tissue by RNA in situ hybridization. (PMID: 26137149) Hu F … Zhang X (Oncology letters 2015) 2 3 58
  3. Prokaryotic expression and characterization of human AC3-33 protein. (PMID: 20515784) Zhang X … Yang W (Frontiers in bioscience (Elite edition) 2010) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for C3orf33 Gene

Sources for C3orf33 Gene

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