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Aliases for C3orf20 Gene

Aliases for C3orf20 Gene

  • Chromosome 3 Open Reading Frame 20 2 3 5
  • Uncharacterized Protein C3orf20 3

External Ids for C3orf20 Gene

Previous GeneCards Identifiers for C3orf20 Gene

  • GC03P014692

Summaries for C3orf20 Gene

GeneCards Summary for C3orf20 Gene

C3orf20 (Chromosome 3 Open Reading Frame 20) is a Protein Coding gene.

Additional gene information for C3orf20 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf20 Gene

Genomics for C3orf20 Gene

GeneHancer (GH) Regulatory Elements for C3orf20 Gene

Promoters and enhancers for C3orf20 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J014673 Enhancer 0.5 FANTOM5 661.4 -0.6 -576 0.1 CTCF ZNF335 POLR2A SUPT5H C3orf20 CCDC174 NR2C2
GH03J014675 Promoter 0.5 EPDnew 650.7 +0.9 897 0.1 C3orf20 PIR51472
GH03J014401 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -270.0 -269979 5.2 HDGF PKNOX1 CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 SLC6A6 CCDC174 NR2C2 ENSG00000230172 ENSG00000223398 HDAC11-AS1 MRPS25 XPC SH3BP5-AS1 ENSG00000228242
GH03J015323 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.9 +654.5 654531 11.1 HDGF PKNOX1 CLOCK FOXA2 SIN3A FEZF1 ZBTB7B IRF4 YY1 ZNF143 SH3BP5 CCDC174 SH3BP5-AS1 NR2C2 RBSN ENSG00000230172 CAPN7 HACL1 C3orf20 METTL6
GH03J013878 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 10.9 -794.6 -794608 3.2 KLF17 ZNF2 RAD21 ZEB1 ZNF335 GLIS2 CREM EGR2 SP3 ZNF280D WNT7A HDAC11-AS1 ENSG00000223398 ENSG00000230172 C3orf20 VN1R20P GC03M014606
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C3orf20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C3orf20 gene promoter:
  • oct-B3
  • Nkx6-1
  • GATA-2
  • Oct-B1
  • oct-B2
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for C3orf20 Gene

Genomic Locations for C3orf20 Gene
98,812 bases
Plus strand
97,938 bases
Plus strand

Genomic View for C3orf20 Gene

Genes around C3orf20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf20 Gene

Proteins for C3orf20 Gene

  • Protein details for C3orf20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C3orf20
    Protein Accession:
    Secondary Accessions:
    • Q7L0U6
    • Q8NCP2
    • Q9H0I7

    Protein attributes for C3orf20 Gene

    904 amino acids
    Molecular mass:
    101266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf20 Gene


neXtProt entry for C3orf20 Gene

Post-translational modifications for C3orf20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C3orf20 Gene

Domains & Families for C3orf20 Gene

Gene Families for C3orf20 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C3orf20 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf20: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C3orf20 Gene

Function for C3orf20 Gene

Phenotypes From GWAS Catalog for C3orf20 Gene

genes like me logo Genes that share phenotypes with C3orf20: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C3orf20 Gene

Localization for C3orf20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf20 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf20 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C3orf20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C3orf20 Gene

Pathways & Interactions for C3orf20 Gene

SuperPathways for C3orf20 Gene

No Data Available

Interacting Proteins for C3orf20 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000253697 Q8ND61-CC020_HUMAN for C3orf20 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C3orf20 Gene


No data available for Pathways by source and SIGNOR curated interactions for C3orf20 Gene

Drugs & Compounds for C3orf20 Gene

No Compound Related Data Available

Transcripts for C3orf20 Gene

mRNA/cDNA for C3orf20 Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C3orf20 Gene

Chromosome 3 open reading frame 20:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf20 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -

Relevant External Links for C3orf20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C3orf20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf20 Gene

mRNA differential expression in normal tissues according to GTEx for C3orf20 Gene

This gene is overexpressed in Testis (x35.2).

Protein differential expression in normal tissues from HIPED for C3orf20 Gene

This gene is overexpressed in Heart (23.2), Tlymphocyte (10.8), Fetal gut (10.0), Kidney (9.4), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C3orf20 Gene

NURSA nuclear receptor signaling pathways regulating expression of C3orf20 Gene:


SOURCE GeneReport for Unigene cluster for C3orf20 Gene:


Evidence on tissue expression from TISSUES for C3orf20 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C3orf20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf20 Gene

Orthologs for C3orf20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C3H3orf20 33
  • 99.26 (n)
C3orf20 34
  • 99 (a)
(Canis familiaris)
Mammalia C20H3orf20 33
  • 79.57 (n)
C3orf20 34
  • 66 (a)
(Bos Taurus)
Mammalia C22H3orf20 33
  • 78.73 (n)
C3orf20 34
  • 66 (a)
(Rattus norvegicus)
Mammalia RGD1560289 33
  • 74.43 (n)
(Mus musculus)
Mammalia 4930590J08Rik 16 34 33
  • 74.24 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
-- 34
  • 38 (a)
-- 34
  • 36 (a)
(Monodelphis domestica)
Mammalia C3orf20 34
  • 29 (a)
(Anolis carolinensis)
Reptilia C3orf20 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for C3orf20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C3orf20 Gene

Gene Tree for C3orf20 (if available)
Gene Tree for C3orf20 (if available)

Paralogs for C3orf20 Gene

No data available for Paralogs for C3orf20 Gene

Variants for C3orf20 Gene

Sequence variations from dbSNP and Humsavar for C3orf20 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000017181 -- 14,692,785(+) A/G intron_variant
rs1000040492 -- 14,729,757(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000140173 -- 14,771,160(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000170897 -- 14,719,132(+) /G intron_variant
rs1000222197 -- 14,744,240(+) A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf20 Gene

Variant ID Type Subtype PubMed ID
esv2658697 CNV deletion 23128226
esv2667245 CNV deletion 23128226
esv2671265 CNV deletion 23128226
esv2724945 CNV deletion 23290073
esv2724959 CNV deletion 23290073
esv33420 CNV gain 17666407
esv3568627 CNV loss 25503493
esv3595373 CNV loss 21293372
esv3595374 CNV loss 21293372
esv3595375 CNV loss 21293372
nsv507082 OTHER sequence alteration 20534489
nsv508210 CNV deletion 20534489
nsv520162 CNV loss 19592680
nsv589777 CNV loss 21841781
nsv589778 CNV loss 21841781
nsv999144 CNV gain 25217958

Variation tolerance for C3orf20 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.88; 98.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C3orf20 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf20 Gene

Disorders for C3orf20 Gene

Additional Disease Information for C3orf20

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C3orf20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf20 Gene

Publications for C3orf20 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for C3orf20 Gene

Sources for C3orf20 Gene

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