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Aliases for C3orf14 Gene

Aliases for C3orf14 Gene

  • Chromosome 3 Open Reading Frame 14 2 3 5
  • Uncharacterized Protein C3orf14 3
  • HT021 3

External Ids for C3orf14 Gene

Previous GeneCards Identifiers for C3orf14 Gene

  • GC03P062279

Summaries for C3orf14 Gene

GeneCards Summary for C3orf14 Gene

C3orf14 (Chromosome 3 Open Reading Frame 14) is a Protein Coding gene.

Additional gene information for C3orf14 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf14 Gene

Genomics for C3orf14 Gene

GeneHancer (GH) Regulatory Elements for C3orf14 Gene

Promoters and enhancers for C3orf14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J062318 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 665.6 +0.2 162 1.8 CLOCK ZNF133 SIN3A YY1 ETS1 ZNF213 ZNF143 KLF7 ATF7 KLF13 C3orf14 PTPRG-AS1
GH03J062437 Enhancer 0.5 FANTOM5 1.8 +118.2 118223 0.3 ZSCAN4 ZSCAN29 BMI1 CADPS FEZF2 C3orf14 GC03P062465 LOC105377647
GH03J062260 Enhancer 0.2 FANTOM5 1.8 -58.5 -58471 0 C3orf14 PIR41274 PTPRG
GH03J062326 Enhancer 0.6 FANTOM5 0.4 +7.2 7206 0.1 SMARCE1 ZNF217 GATA3 FOSL2 ZNF384 C3orf14 PTPRG-AS1
GH03J062334 Enhancer 0.4 UCNEbase 0.4 +15.6 15594 0.2 C3orf14 PTPRG-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C3orf14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C3orf14 gene promoter:

Genomic Locations for C3orf14 Gene

Genomic Locations for C3orf14 Gene
chr3:62,318,973-62,336,213
(GRCh38/hg38)
Size:
17,241 bases
Orientation:
Plus strand
chr3:62,304,648-62,321,888
(GRCh37/hg19)

Genomic View for C3orf14 Gene

Genes around C3orf14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf14 Gene

Proteins for C3orf14 Gene

  • Protein details for C3orf14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBI5-CC014_HUMAN
    Recommended name:
    Uncharacterized protein C3orf14
    Protein Accession:
    Q9HBI5
    Secondary Accessions:
    • B2R9U0

    Protein attributes for C3orf14 Gene

    Size:
    128 amino acids
    Molecular mass:
    15007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C3orf14 Gene

Post-translational modifications for C3orf14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C3orf14 Gene

Domains & Families for C3orf14 Gene

Gene Families for C3orf14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C3orf14 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf14: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C3orf14 Gene

Function for C3orf14 Gene

genes like me logo Genes that share phenotypes with C3orf14: view

miRNA for C3orf14 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf14 Gene

Localization for C3orf14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf14 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C3orf14 Gene

Pathways & Interactions for C3orf14 Gene

SuperPathways for C3orf14 Gene

No Data Available

Interacting Proteins for C3orf14 Gene

Selected Interacting proteins: Q9HBI5-CC014_HUMAN for C3orf14 Gene via IID

Symbol External ID(s) Details
CEP89

Gene Ontology (GO) - Biological Process for C3orf14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf14 Gene

Drugs & Compounds for C3orf14 Gene

No Compound Related Data Available

Transcripts for C3orf14 Gene

Unigene Clusters for C3orf14 Gene

Chromosome 3 open reading frame 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6:
SP7: - -

Relevant External Links for C3orf14 Gene

GeneLoc Exon Structure for
C3orf14
ECgene alternative splicing isoforms for
C3orf14

Expression for C3orf14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C3orf14 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C3orf14 Gene



NURSA nuclear receptor signaling pathways regulating expression of C3orf14 Gene:

C3orf14

SOURCE GeneReport for Unigene cluster for C3orf14 Gene:

Hs.47166

Evidence on tissue expression from TISSUES for C3orf14 Gene

  • Pancreas(2.5)
genes like me logo Genes that share expression patterns with C3orf14: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf14 Gene

Orthologs for C3orf14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf14 33
  • 100 (n)
C3orf14 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H3orf14 33
  • 90.29 (n)
C3orf14 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC102632117 33
  • 83.76 (n)
3830406C13Rik 34
  • 69 (a)
OneToOne
Gm30274 16
cow
(Bos Taurus)
Mammalia C22H3orf14 33
  • 82.81 (n)
C3orf14 34
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306063 33
  • 80.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf14 34
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C3orf14 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves C12H3ORF14 33
  • 68.14 (n)
C3orf14 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf14 34
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gb:bc152504 33
  • 52.91 (n)
C11H3orf14 34
  • 37 (a)
OneToOne
Species where no ortholog for C3orf14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf14 Gene

ENSEMBL:
Gene Tree for C3orf14 (if available)
TreeFam:
Gene Tree for C3orf14 (if available)

Paralogs for C3orf14 Gene

No data available for Paralogs for C3orf14 Gene

Variants for C3orf14 Gene

Sequence variations from dbSNP and Humsavar for C3orf14 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000314619 -- 62,332,174(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000417449 -- 62,331,702(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000429488 -- 62,325,437(+) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000581506 -- 62,330,197(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000656427 -- 62,330,463(+) A/G genic_downstream_transcript_variant, intron_variant

Variation tolerance for C3orf14 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C3orf14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C3orf14 Gene

Disorders for C3orf14 Gene

Additional Disease Information for C3orf14

No disorders were found for C3orf14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf14 Gene

Publications for C3orf14 Gene

  1. DNA methylation in glioblastoma: impact on gene expression and clinical outcome. (PMID: 21156036) Etcheverry A … Mosser J (BMC genomics 2010) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58

Products for C3orf14 Gene

Sources for C3orf14 Gene

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