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Aliases for C2orf81 Gene

Aliases for C2orf81 Gene

  • Chromosome 2 Open Reading Frame 81 2 3 5
  • Uncharacterized Protein C2orf81 3
  • HCG40743 3

External Ids for C2orf81 Gene

Previous GeneCards Identifiers for C2orf81 Gene

  • GC02M074473
  • GC02M074641
  • GC02M074377
  • GC02M074415
  • GC02M074417
  • GC02M074393
  • GC02M074428
  • GC02M074430
  • GC02M074432

Summaries for C2orf81 Gene

GeneCards Summary for C2orf81 Gene

C2orf81 (Chromosome 2 Open Reading Frame 81) is a Protein Coding gene. An important paralog of this gene is ENSG00000159239.

Additional gene information for C2orf81 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf81 Gene

Genomics for C2orf81 Gene

GeneHancer (GH) Regulatory Elements for C2orf81 Gene

Promoters and enhancers for C2orf81 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J074421 Enhancer 0.4 Ensembl 650.7 +1.7 1690 0.2 HDGF MEF2B ATF2 C2orf81 ENSG00000159239 GC02M074419 WDR54 PIR40772 HMGA1P8
GH02J074372 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 10.7 +47.6 47602 2.5 MEIS2 MXI1 KLF1 ATF1 SIN3A ZFHX2 POLR2A ZNF600 ATF7 CREM GC02M074371 DCTN1 SLC4A5 C2orf81 ENSG00000159239 WDR54 RTKN BOLA3 BOLA3-AS1 ENSG00000272183
GH02J074575 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -155.5 -155498 3.4 PKNOX1 MAX CEBPG EBF1 BATF IRF4 ZBTB40 GATA3 POLR2A EED DOK1 LOXL3 HTRA2 AUP1 DQX1 TLX2 PCGF1 LBX2 TTC31 CCDC142
GH02J074266 Enhancer 0.8 ENCODE 10 +154.3 154286 1.2 HDAC1 ELF3 ATF1 PKNOX1 FOXA2 RB1 ZBTB40 RAD21 RARA ATF7 SLC4A5 C2orf81 ENSG00000159239 WDR54 RTKN KRT18P26 GC02P074217 ENSG00000264324
GH02J074420 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.2 -2.5 -2537 8.1 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF207 ZNF143 PAF1 WDR54 ENSG00000272183 LBX2 LBX2-AS1 HTRA2 C2orf81 SLC4A5 DCTN1 ENSG00000159239 PIR40772
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C2orf81 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C2orf81 gene promoter:
  • COMP1
  • Nkx2-5
  • GCNF-2
  • GCNF-1
  • GCNF
  • MyoD
  • Tal-1
  • E47
  • SREBP-1a
  • SREBP-1b

Genomic Locations for C2orf81 Gene

Genomic Locations for C2orf81 Gene
7,416 bases
Minus strand
7,416 bases
Minus strand

Genomic View for C2orf81 Gene

Genes around C2orf81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf81 Gene

Proteins for C2orf81 Gene

  • Protein details for C2orf81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C2orf81
    Protein Accession:
    Secondary Accessions:
    • A0A087WXZ4

    Protein attributes for C2orf81 Gene

    582 amino acids
    Molecular mass:
    63239 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf81 Gene

Post-translational modifications for C2orf81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf81 Gene

Domains & Families for C2orf81 Gene

Gene Families for C2orf81 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C2orf81 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf81: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf81 Gene

Function for C2orf81 Gene

Phenotypes From GWAS Catalog for C2orf81 Gene

genes like me logo Genes that share phenotypes with C2orf81: view

Animal Model Products

miRNA for C2orf81 Gene

miRTarBase miRNAs that target C2orf81

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf81 Gene

Localization for C2orf81 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf81 gene
Compartment Confidence
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf81 Gene

Pathways & Interactions for C2orf81 Gene

SuperPathways for C2orf81 Gene

No Data Available

Interacting Proteins for C2orf81 Gene

Gene Ontology (GO) - Biological Process for C2orf81 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf81 Gene

Drugs & Compounds for C2orf81 Gene

No Compound Related Data Available

Transcripts for C2orf81 Gene

mRNA/cDNA for C2orf81 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf81 Gene

Chromosome 2 open reading frame 81:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf81 Gene

No ASD Table

Relevant External Links for C2orf81 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf81 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf81 Gene

This gene is overexpressed in Testis (x6.3) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for C2orf81 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf81 Gene

Protein tissue co-expression partners for C2orf81 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C2orf81 Gene:


SOURCE GeneReport for Unigene cluster for C2orf81 Gene:

genes like me logo Genes that share expression patterns with C2orf81: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf81 Gene

Orthologs for C2orf81 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf81 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C11H2orf81 33
  • 78.13 (n)
(Canis familiaris)
Mammalia C17H2orf81 33
  • 75.78 (n)
(Mus musculus)
Mammalia 1700003E16Rik 16 33
  • 68.23 (n)
(Rattus norvegicus)
Mammalia LOC500227 33
  • 67.8 (n)
Species where no ortholog for C2orf81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf81 Gene

Gene Tree for C2orf81 (if available)
Gene Tree for C2orf81 (if available)

Paralogs for C2orf81 Gene

Paralogs for C2orf81 Gene

genes like me logo Genes that share paralogs with C2orf81: view

Variants for C2orf81 Gene

Sequence variations from dbSNP and Humsavar for C2orf81 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000002846 -- 74,415,088(-) G/T coding_sequence_variant, missense_variant
rs1000603634 -- 74,416,706(-) T/C intron_variant
rs1000909908 -- 74,419,041(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002221556 -- 74,419,107(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002510898 -- 74,420,131(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf81 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv1072414 CNV deletion 25765185
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for C2orf81 Gene

Gene Damage Index Score: 2.63; 45.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf81 Gene

Disorders for C2orf81 Gene

Additional Disease Information for C2orf81

No disorders were found for C2orf81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf81 Gene

Publications for C2orf81 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 2 3 4 58

Products for C2orf81 Gene

Sources for C2orf81 Gene

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