Aliases for C2orf74 Gene

Aliases for C2orf74 Gene

  • Chromosome 2 Open Reading Frame 74 2 3 5
  • Uncharacterized Protein C2orf74 3 4

External Ids for C2orf74 Gene

Previous GeneCards Identifiers for C2orf74 Gene

  • GC02P061225
  • GC02P061372
  • GC02P061113

Summaries for C2orf74 Gene

GeneCards Summary for C2orf74 Gene

C2orf74 (Chromosome 2 Open Reading Frame 74) is a Protein Coding gene. Diseases associated with C2orf74 include Peroxisome Biogenesis Disorder 11A.

Additional gene information for C2orf74 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C2orf74 Gene

Genomics for C2orf74 Gene

GeneHancer (GH) Regulatory Elements for C2orf74 Gene

Promoters and enhancers for C2orf74 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J061144 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 232 2.2 FOXK2 ZBTB40 ZNF217 POLR2G PHF8 POLR2A RFX1 TGIF2 MXI1 RBM25 LOC339803 C2orf74 piR-40315 piR-48957 AHSA2P piR-52389 ENSG00000274769 KIAA1841
GH02J061146 Enhancer 0.2 Ensembl 500.7 +1.6 1633 0.2 C2orf74 LOC339803 piR-40315 AHSA2P piR-52389 ENSG00000274769 KIAA1841
GH02J060837 Enhancer 1.2 FANTOM5 Ensembl ENCODE 3.5 -304.8 -304824 5.1 RELA MEF2C REST POLR2A BCL11A TCF12 RXRA CBFB CTCF ARNT PAPOLG REL LINC01185 KIAA1841 AHSA2P PUS10 ENSG00000232713 C2orf74 PEX13 lnc-PUS10-2
GH02J061156 Enhancer 0.7 FANTOM5 Ensembl 0.4 +13.4 13433 3.8 RXRA HNF4A SPI1 HLF HNF4G SP1 AHSA2P ENSG00000273302 REL LOC105374758 piR-52389 C2orf74 ENSG00000274769 KIAA1841
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C2orf74 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C2orf74

Top Transcription factor binding sites by QIAGEN in the C2orf74 gene promoter:
  • AREB6
  • FOXJ2
  • FOXJ2 (long isoform)
  • JunB
  • JunD
  • Nkx6-1
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for C2orf74 Gene

Genomic Locations for C2orf74 Gene
chr2:61,145,068-61,164,830
(GRCh38/hg38)
Size:
19,763 bases
Orientation:
Plus strand
chr2:61,372,243-61,391,964
(GRCh37/hg19)
Size:
19,722 bases
Orientation:
Plus strand

Genomic View for C2orf74 Gene

Genes around C2orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf74 Gene

Proteins for C2orf74 Gene

  • Protein details for C2orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MZ97-CB074_HUMAN
    Recommended name:
    Uncharacterized protein C2orf74
    Protein Accession:
    A8MZ97
    Secondary Accessions:
    • C9JP62

    Protein attributes for C2orf74 Gene

    Size:
    194 amino acids
    Molecular mass:
    21915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf74 Gene

Post-translational modifications for C2orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf74 Gene

Domains & Families for C2orf74 Gene

Gene Families for C2orf74 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C2orf74 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C2orf74: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C2orf74 Gene

Function for C2orf74 Gene

Phenotypes From GWAS Catalog for C2orf74 Gene

genes like me logo Genes that share phenotypes with C2orf74: view

Animal Models for C2orf74 Gene

MGI Knock Outs for C2orf74:

miRNA for C2orf74 Gene

miRTarBase miRNAs that target C2orf74

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C2orf74 Gene

Localization for C2orf74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2orf74 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf74 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C2orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C2orf74: view

Pathways & Interactions for C2orf74 Gene

PathCards logo

SuperPathways for C2orf74 Gene

No Data Available

Interacting Proteins for C2orf74 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000402915 A8MZ97-CB074_HUMAN for C2orf74 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for C2orf74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf74 Gene

Drugs & Compounds for C2orf74 Gene

No Compound Related Data Available

Transcripts for C2orf74 Gene

mRNA/cDNA for C2orf74 Gene

6 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf74 Gene

No ASD Table

Relevant External Links for C2orf74 Gene

GeneLoc Exon Structure for
C2orf74

Expression for C2orf74 Gene

Protein differential expression in normal tissues from HIPED for C2orf74 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf74 Gene



Protein tissue co-expression partners for C2orf74 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C2orf74

SOURCE GeneReport for Unigene cluster for C2orf74 Gene:

Hs.140617

Evidence on tissue expression from TISSUES for C2orf74 Gene

  • Nervous system(2.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf74 Gene

Orthologs for C2orf74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2orf74 31
  • 100 (a)
OneToOne
C2AH2orf74 30
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia C10H2orf74 30
  • 83.51 (n)
C2orf74 31
  • 40 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf74 30
  • 81.62 (n)
C2orf74 31
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700093K21Rik 17 31 30
  • 74.34 (n)
rat
(Rattus norvegicus)
Mammalia LOC690352 30
  • 69.71 (n)
Species where no ortholog for C2orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf74 Gene

ENSEMBL:
Gene Tree for C2orf74 (if available)
TreeFam:
Gene Tree for C2orf74 (if available)

Paralogs for C2orf74 Gene

No data available for Paralogs for C2orf74 Gene

Variants for C2orf74 Gene

Additional dbSNP identifiers (rs#s) for C2orf74 Gene

Structural Variations from Database of Genomic Variants (DGV) for C2orf74 Gene

Variant ID Type Subtype PubMed ID
dgv702e214 CNV loss 21293372
esv2760616 CNV loss 21179565
esv3583840 CNV loss 25503493
esv3591015 CNV gain 21293372
nsv518805 CNV loss 19592680

Variation tolerance for C2orf74 Gene

Gene Damage Index Score: 9.75; 89.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C2orf74 Gene

Disorders for C2orf74 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C2orf74 Gene - From: DISEASES

Disorder Aliases PubMed IDs
peroxisome biogenesis disorder 11a
  • pbd11a
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C2orf74

genes like me logo Genes that share disorders with C2orf74: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C2orf74 Gene

Publications for C2orf74 Gene

  1. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L … Cho JH (Nature 2012) 3 54
  2. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3 54
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 54
  4. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 54
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 54

Products for C2orf74 Gene

Sources for C2orf74 Gene