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Aliases for C2orf70 Gene

Aliases for C2orf70 Gene

  • Chromosome 2 Open Reading Frame 70 2 3 5
  • Hypothetical Protein LOC339778 2
  • UPF0573 Protein C2orf70 3

External Ids for C2orf70 Gene

Previous GeneCards Identifiers for C2orf70 Gene

  • GC02P026638
  • GC02P026785

Summaries for C2orf70 Gene

GeneCards Summary for C2orf70 Gene

C2orf70 (Chromosome 2 Open Reading Frame 70) is a Protein Coding gene.

Additional gene information for C2orf70 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf70 Gene

Genomics for C2orf70 Gene

GeneHancer (GH) Regulatory Elements for C2orf70 Gene

Promoters and enhancers for C2orf70 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J026562 Enhancer 1 Ensembl ENCODE 650.7 +0.3 260 1.3 ELF3 FOXA2 ARID4B SIN3A BMI1 RAD21 ZNF48 YY1 RCOR1 SP5 C2orf70 KCNK3 GC02P026627
GH02J026717 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.9 +159.7 159699 10.1 HDGF FOXA2 MLX SIN3A DMAP1 YY1 ZNF766 FOS SP5 REST EIF2B4 GPN1 CAD NRBP1 GTF3C2-AS1 ASXL2 CENPA LOC105374363 KCNK3 TMEM214
GH02J026492 Enhancer 0.8 ENCODE 11.3 -69.6 -69608 0.2 HDAC1 MEIS2 PKNOX1 TEAD4 TAL1 TCF12 ZFHX2 CTBP1 ZNF766 GATA2 OTOF C2orf70 DRC1
GH02J026494 Enhancer 0.7 ENCODE 11.3 -69.5 -69452 0.1 HDAC1 MEIS2 PKNOX1 TEAD4 TAL1 TCF12 CTBP1 ZNF766 GATA2 NCOR1 C2orf70 OTOF DRC1
GH02J026493 Enhancer 0.6 FANTOM5 11.3 -68.8 -68838 0.4 STAT1 POLR2A ZNF512 STAT2 CEBPB PRDM10 ATF2 SPI1 OTOF C2orf70 RAB10 GAREM2 DRC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C2orf70 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C2orf70 gene promoter:
  • p53
  • Meis-1b
  • Meis-1a
  • Meis-1
  • HSF2
  • ZIC2
  • RSRFC4
  • RFX1
  • POU3F2
  • HNF-1A

Genomic Locations for C2orf70 Gene

Genomic Locations for C2orf70 Gene
16,977 bases
Plus strand
16,951 bases
Plus strand

Genomic View for C2orf70 Gene

Genes around C2orf70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf70 Gene

Proteins for C2orf70 Gene

  • Protein details for C2orf70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0573 protein C2orf70
    Protein Accession:

    Protein attributes for C2orf70 Gene

    201 amino acids
    Molecular mass:
    23421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf70 Gene

Post-translational modifications for C2orf70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf70 Gene

Domains & Families for C2orf70 Gene

Gene Families for C2orf70 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C2orf70 Gene


Suggested Antigen Peptide Sequences for C2orf70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0573 family.
  • Belongs to the UPF0573 family.
genes like me logo Genes that share domains with C2orf70: view

Function for C2orf70 Gene

Phenotypes From GWAS Catalog for C2orf70 Gene

genes like me logo Genes that share phenotypes with C2orf70: view

Animal Models for C2orf70 Gene

MGI Knock Outs for C2orf70:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf70 Gene

Localization for C2orf70 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf70 gene
Compartment Confidence
nucleus 5
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C2orf70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with C2orf70: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C2orf70 Gene

Pathways & Interactions for C2orf70 Gene

SuperPathways for C2orf70 Gene

No Data Available

Interacting Proteins for C2orf70 Gene

Gene Ontology (GO) - Biological Process for C2orf70 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf70 Gene

Drugs & Compounds for C2orf70 Gene

No Compound Related Data Available

Transcripts for C2orf70 Gene

mRNA/cDNA for C2orf70 Gene

Unigene Clusters for C2orf70 Gene

Chromosome 2 open reading frame 70:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf70 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: -

Relevant External Links for C2orf70 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C2orf70 Gene

This gene is overexpressed in Testis (x27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf70 Gene

Protein tissue co-expression partners for C2orf70 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C2orf70 Gene:


SOURCE GeneReport for Unigene cluster for C2orf70 Gene:

genes like me logo Genes that share expression patterns with C2orf70: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf70 Gene

Orthologs for C2orf70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf70 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C2AH2orf70 33
  • 97.25 (n)
C2orf70 34
  • 90 (a)
(Canis familiaris)
Mammalia C17H2orf70 33
  • 84.58 (n)
C2orf70 34
  • 78 (a)
(Bos Taurus)
Mammalia C11H2orf70 34 33
  • 83.91 (n)
(Mus musculus)
Mammalia 1700001C02Rik 16 34 33
  • 77 (n)
(Rattus norvegicus)
Mammalia RGD1559683 33
  • 76.33 (n)
(Monodelphis domestica)
Mammalia C2orf70 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia C2orf70 34
  • 60 (a)
(Gallus gallus)
Aves C3H2ORF70 33
  • 64.47 (n)
C2orf70 34
  • 54 (a)
(Anolis carolinensis)
Reptilia C2orf70 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf70 33
  • 62.25 (n)
(Danio rerio)
Actinopterygii si:ch211-198b3.4 33
  • 53.79 (n)
C20H2orf70 34
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for C2orf70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf70 Gene

Gene Tree for C2orf70 (if available)
Gene Tree for C2orf70 (if available)

Paralogs for C2orf70 Gene

No data available for Paralogs for C2orf70 Gene

Variants for C2orf70 Gene

Sequence variations from dbSNP and Humsavar for C2orf70 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000015832 -- 26,572,467(+) G/A 5_prime_UTR_variant, intron_variant
rs1000171885 -- 26,581,276(+) A/T downstream_transcript_variant
rs1000284351 -- 26,576,912(+) C/G intron_variant
rs1000435656 -- 26,581,092(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000766464 -- 26,571,281(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf70 Gene

Variant ID Type Subtype PubMed ID
esv33316 CNV loss 17666407
esv3583675 CNV loss 25503493
nsv517800 CNV loss 19592680

Variation tolerance for C2orf70 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf70 Gene

Disorders for C2orf70 Gene

Additional Disease Information for C2orf70

No disorders were found for C2orf70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf70 Gene

Publications for C2orf70 Gene

  1. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for C2orf70 Gene

Sources for C2orf70 Gene

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