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Aliases for C2orf68 Gene

Aliases for C2orf68 Gene

  • Chromosome 2 Open Reading Frame 68 2 3 5
  • UPF0561 Protein C2orf68 3
  • HCRCN81 3

External Ids for C2orf68 Gene

Previous GeneCards Identifiers for C2orf68 Gene

  • GC02M085688
  • GC02M085832
  • GC02M085729

Summaries for C2orf68 Gene

GeneCards Summary for C2orf68 Gene

C2orf68 (Chromosome 2 Open Reading Frame 68) is a Protein Coding gene. Diseases associated with C2orf68 include Colorectal Adenocarcinoma.

Additional gene information for C2orf68 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf68 Gene

Genomics for C2orf68 Gene

GeneHancer (GH) Regulatory Elements for C2orf68 Gene

Promoters and enhancers for C2orf68 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J085611 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 664 +0.1 141 1.9 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF143 C2orf68 SNORD94 ELMOD3 LOC100996506 POLR1A TCF7L1 LOC105374845 MAT2A USP39 TMEM150A
GH02J085536 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 54.5 +72.3 72306 6.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PARTICL PIR40998 GC02M085541 PIR39955 MAT2A USP39 SNORD94 C2orf68 LOC100996506 KDM3A
GH02J086440 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 34.8 -830.0 -829959 3.6 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 KDM3A GC02M086437 LOC102724642 SNORD94 C2orf68 ENSG00000231259 USP39 LOC100420889 LOC105374845 PTCD3
GH02J086193 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.3 -583.4 -583382 3.9 ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 IMMT MRPL35 GC02P086196 ENSG00000273080 LOC102724642 SNORD94 ENSG00000231259 LOC100420889 KDM3A USP39
GH02J085236 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 24.8 +374.2 374173 1.9 ZFP64 MAX ZNF140 ZNF266 SIN3A ZBTB40 ZNF697 ZNF664 POLR2A ZNF547 SNORD94 C2orf68 ELMOD3 LOC100996506 USP39 RNU6-674P TCF7L1 POLR1A MAT2A SH2D6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C2orf68 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C2orf68 gene promoter:
  • AP-1
  • JunD
  • Brachyury
  • c-Fos
  • c-Jun
  • FosB
  • JunB
  • Fra-1
  • Pax-5
  • Elk-1

Genomic Locations for C2orf68 Gene

Genomic Locations for C2orf68 Gene
6,814 bases
Minus strand
6,814 bases
Minus strand

Genomic View for C2orf68 Gene

Genes around C2orf68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf68 Gene

Proteins for C2orf68 Gene

  • Protein details for C2orf68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0561 protein C2orf68
    Protein Accession:
    Secondary Accessions:
    • B4DT10
    • Q4G0J7
    • Q6ZVA6

    Protein attributes for C2orf68 Gene

    166 amino acids
    Molecular mass:
    18751 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C2orf68 Gene


neXtProt entry for C2orf68 Gene

Post-translational modifications for C2orf68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf68 Gene

No data available for DME Specific Peptides for C2orf68 Gene

Domains & Families for C2orf68 Gene

Gene Families for C2orf68 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C2orf68 Gene


Suggested Antigen Peptide Sequences for C2orf68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0561 family.
  • Belongs to the UPF0561 family.
genes like me logo Genes that share domains with C2orf68: view

Function for C2orf68 Gene

Phenotypes From GWAS Catalog for C2orf68 Gene

genes like me logo Genes that share phenotypes with C2orf68: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C2orf68

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf68 Gene

Localization for C2orf68 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf68 gene
Compartment Confidence
nucleus 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear membrane (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf68 Gene

Pathways & Interactions for C2orf68 Gene

SuperPathways for C2orf68 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C2orf68 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf68 Gene

Drugs & Compounds for C2orf68 Gene

No Compound Related Data Available

Transcripts for C2orf68 Gene

mRNA/cDNA for C2orf68 Gene

Unigene Clusters for C2orf68 Gene

Chromosome 2 open reading frame 68:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C2orf68

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf68 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -

Relevant External Links for C2orf68 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf68 Gene

NURSA nuclear receptor signaling pathways regulating expression of C2orf68 Gene:


SOURCE GeneReport for Unigene cluster for C2orf68 Gene:


Evidence on tissue expression from TISSUES for C2orf68 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with C2orf68: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf68 Gene

Orthologs for C2orf68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf68 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C2AH2orf68 33
  • 99.4 (n)
C2orf68 34
  • 98 (a)
(Canis familiaris)
Mammalia C17H2orf68 33
  • 90.36 (n)
C2orf68 34
  • 61 (a)
(Bos Taurus)
Mammalia C11H2orf68 33
  • 88.62 (n)
C2orf68 34
  • 86 (a)
(Rattus norvegicus)
Mammalia LOC691113 33
  • 87.55 (n)
(Mus musculus)
Mammalia 0610030E20Rik 16 34 33
  • 85.34 (n)
(Monodelphis domestica)
Mammalia C2orf68 34
  • 78 (a)
(Anolis carolinensis)
Reptilia C2orf68 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495513 33
  • 64.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19302 33
(Danio rerio)
Actinopterygii si:ch211-283h6.4 33
  • 59.13 (n)
C5H2orf68 34
  • 51 (a)
Species where no ortholog for C2orf68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf68 Gene

Gene Tree for C2orf68 (if available)
Gene Tree for C2orf68 (if available)

Paralogs for C2orf68 Gene

(1) SIMAP similar genes for C2orf68 Gene using alignment to 3 proteins:

  • CB068_HUMAN
  • F6S878_HUMAN
  • H7C1Q5_HUMAN
genes like me logo Genes that share paralogs with C2orf68: view

No data available for Paralogs for C2orf68 Gene

Variants for C2orf68 Gene

Sequence variations from dbSNP and Humsavar for C2orf68 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000033559 -- 85,605,076(-) A/G downstream_transcript_variant
rs1000106784 -- 85,605,460(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000211109 -- 85,612,206(-) C/T upstream_transcript_variant
rs1000351466 -- 85,611,292(-) A/T intron_variant
rs1000410980 -- 85,612,056(-) C/T 5_prime_UTR_variant

Variation tolerance for C2orf68 Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C2orf68 Gene

Disorders for C2orf68 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C2orf68 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C2orf68

genes like me logo Genes that share disorders with C2orf68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C2orf68 Gene

Publications for C2orf68 Gene

  1. The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. (PMID: 25023051) Wen X … Chen Y (Medical oncology (Northwood, London, England) 2014) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer. (PMID: 26607374) Chen Y … He K (Medical oncology (Northwood, London, England) 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for C2orf68 Gene

Sources for C2orf68 Gene

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