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Aliases for C2orf66 Gene

Aliases for C2orf66 Gene

  • Chromosome 2 Open Reading Frame 66 2 3 5
  • Uncharacterized Protein C2orf66 3
  • IIDS6411 3
  • UNQ6411 3

External Ids for C2orf66 Gene

Previous GeneCards Identifiers for C2orf66 Gene

  • GC02M197379
  • GC02M197669
  • GC02M189522

Summaries for C2orf66 Gene

GeneCards Summary for C2orf66 Gene

C2orf66 (Chromosome 2 Open Reading Frame 66) is a Protein Coding gene.

Additional gene information for C2orf66 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf66 Gene

Genomics for C2orf66 Gene

GeneHancer (GH) Regulatory Elements for C2orf66 Gene

Promoters and enhancers for C2orf66 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I196810 Promoter 0.5 EPDnew 550.8 +0.0 12 0.1 C2orf66 GTF3C3
GH02I196639 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.2 +170.2 170219 2 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CCDC150 LOC105373823 SF3B1 NPM1P46 GTF3C3 LOC101927482 C2orf66 ANKRD44 GC02M196687 ENSG00000252923
GH02I196924 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.4 -116.2 -116201 3.8 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 PGAP1 GTF3C3 SF3B1 NPM1P46 LOC101927482 C2orf66 GC02P196852
GH02I196266 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 4 +541.6 541647 3.8 HDGF BATF IRF4 THRB IKZF2 RUNX3 SMARCA5 JUNB ELF1 ZEB2 STK17B LOC101927482 C2orf66 GC02P196292 HECW2
GH02I196258 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.1 +548.5 548547 5.7 PKNOX1 CLOCK ATF1 FOXA2 SMAD1 ARNT IRF4 TCF12 ZNF143 FOS LOC101927482 STK17B C2orf66 GC02P196292 HECW2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C2orf66 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C2orf66 gene promoter:

Genomic Locations for C2orf66 Gene

Genomic Locations for C2orf66 Gene
chr2:196,804,415-196,810,276
(GRCh38/hg38)
Size:
5,862 bases
Orientation:
Minus strand
chr2:197,669,726-197,675,000
(GRCh37/hg19)

Genomic View for C2orf66 Gene

Genes around C2orf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf66 Gene

Proteins for C2orf66 Gene

  • Protein details for C2orf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXQ4-CB066_HUMAN
    Recommended name:
    Uncharacterized protein C2orf66
    Protein Accession:
    Q6UXQ4
    Secondary Accessions:
    • B2RNW3

    Protein attributes for C2orf66 Gene

    Size:
    117 amino acids
    Molecular mass:
    13321 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf66 Gene

Post-translational modifications for C2orf66 Gene

No Post-translational modifications

Other Protein References for C2orf66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf66 Gene

Domains & Families for C2orf66 Gene

Gene Families for C2orf66 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C2orf66 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf66: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf66 Gene

Function for C2orf66 Gene

Phenotypes From GWAS Catalog for C2orf66 Gene

genes like me logo Genes that share phenotypes with C2orf66: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf66 Gene

Localization for C2orf66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2orf66 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf66 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for C2orf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C2orf66: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C2orf66 Gene

Pathways & Interactions for C2orf66 Gene

SuperPathways for C2orf66 Gene

No Data Available

Interacting Proteins for C2orf66 Gene

Gene Ontology (GO) - Biological Process for C2orf66 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf66 Gene

Drugs & Compounds for C2orf66 Gene

No Compound Related Data Available

Transcripts for C2orf66 Gene

mRNA/cDNA for C2orf66 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf66 Gene

Chromosome 2 open reading frame 66:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf66 Gene

No ASD Table

Relevant External Links for C2orf66 Gene

GeneLoc Exon Structure for
C2orf66
ECgene alternative splicing isoforms for
C2orf66

Expression for C2orf66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf66 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf66 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.9), Pituitary (x6.6), and Brain - Hypothalamus (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of C2orf66 Gene:

C2orf66

SOURCE GeneReport for Unigene cluster for C2orf66 Gene:

Hs.372069
genes like me logo Genes that share expression patterns with C2orf66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf66 Gene

Orthologs for C2orf66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2BH2orf66 33
  • 99.72 (n)
C2orf66 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100139826 33
  • 79.65 (n)
-- 34
  • 72 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C37H2orf66 33
  • 79.61 (n)
rat
(Rattus norvegicus)
Mammalia LOC686030 33
  • 77.89 (n)
mouse
(Mus musculus)
Mammalia LOC102637189 33
  • 77.35 (n)
Gm34066 16
oppossum
(Monodelphis domestica)
Mammalia C2orf66 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7H2ORF66 33
  • 68.25 (n)
Species where no ortholog for C2orf66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf66 Gene

ENSEMBL:
Gene Tree for C2orf66 (if available)
TreeFam:
Gene Tree for C2orf66 (if available)

Paralogs for C2orf66 Gene

No data available for Paralogs for C2orf66 Gene

Variants for C2orf66 Gene

Sequence variations from dbSNP and Humsavar for C2orf66 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000090416 -- 196,806,575(-) G/T intron_variant
rs1000142798 -- 196,806,329(-) C/G intron_variant
rs1000191013 -- 196,810,463(-) T/C upstream_transcript_variant
rs1000475518 -- 196,806,614(-) G/T intron_variant
rs1000763016 -- 196,806,963(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf66 Gene

Variant ID Type Subtype PubMed ID
esv3575323 CNV gain 25503493

Variation tolerance for C2orf66 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf66 Gene

Disorders for C2orf66 Gene

Additional Disease Information for C2orf66

No disorders were found for C2orf66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf66 Gene

Publications for C2orf66 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C2orf66 Gene

Sources for C2orf66 Gene

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