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Aliases for C2orf27B Gene

Aliases for C2orf27B Gene

  • Chromosome 2 Open Reading Frame 27B 2 3 5
  • C2orf27A C2orf27B 4

External Ids for C2orf27B Gene

Previous GeneCards Identifiers for C2orf27B Gene

  • GC02M132270
  • GC02M132552
  • GC02M124546

Summaries for C2orf27B Gene

GeneCards Summary for C2orf27B Gene

C2orf27B (Chromosome 2 Open Reading Frame 27B) is a Protein Coding gene. An important paralog of this gene is C2orf27A.

Additional gene information for C2orf27B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf27B Gene

Genomics for C2orf27B Gene

GeneHancer (GH) Regulatory Elements for C2orf27B Gene

Promoters and enhancers for C2orf27B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I131801 Enhancer 0.8 ENCODE 550.8 -0.4 -352 0.2 CTCF MXI1 KLF1 SAP130 RB1 SIN3A ZNF48 RAD21 CTBP1 GLIS2 C2orf27B C2orf27A ENSG00000274353
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C2orf27B on UCSC Golden Path with GeneCards custom track

Genomic Locations for C2orf27B Gene

Genomic Locations for C2orf27B Gene
6,701 bases
Minus strand

Genomic View for C2orf27B Gene

Genes around C2orf27B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf27B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf27B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf27B Gene

Proteins for C2orf27B Gene

  • Protein details for C2orf27B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C2orf27
    Protein Accession:
    Secondary Accessions:
    • O43575
    • Q2M1X0
    • Q52M10
    • Q86XG2

    Protein attributes for C2orf27B Gene

    203 amino acids
    Molecular mass:
    21517 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C2orf27B Gene


neXtProt entry for C2orf27B Gene

Post-translational modifications for C2orf27B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf27B Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C2orf27B Gene

Domains & Families for C2orf27B Gene

Protein Domains for C2orf27B Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf27B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf27B Gene

Function for C2orf27B Gene

Phenotypes From GWAS Catalog for C2orf27B Gene

genes like me logo Genes that share phenotypes with C2orf27B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf27B Gene

Localization for C2orf27B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf27B gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C2orf27B Gene

Pathways & Interactions for C2orf27B Gene

SuperPathways for C2orf27B Gene

No Data Available

Interacting Proteins for C2orf27B Gene

Selected Interacting proteins: Q580R0-CB027_HUMAN for C2orf27B Gene via IID

Gene Ontology (GO) - Biological Process for C2orf27B Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf27B Gene

Drugs & Compounds for C2orf27B Gene

No Compound Related Data Available

Transcripts for C2orf27B Gene

mRNA/cDNA for C2orf27B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf27B Gene

Chromosome 2 open reading frame 27B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf27B Gene

No ASD Table

Relevant External Links for C2orf27B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf27B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf27B Gene

mRNA differential expression in normal tissues according to GTEx for C2orf27B Gene

This gene is overexpressed in Pancreas (x33.5) and Spleen (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf27B Gene

NURSA nuclear receptor signaling pathways regulating expression of C2orf27B Gene:


SOURCE GeneReport for Unigene cluster for C2orf27B Gene:

genes like me logo Genes that share expression patterns with C2orf27B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf27B Gene

Orthologs for C2orf27B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C2orf27B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC749466 33
  • 97.53 (n)
-- 34
  • 92 (a)
Species where no ortholog for C2orf27B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf27B Gene

Gene Tree for C2orf27B (if available)
Gene Tree for C2orf27B (if available)

Paralogs for C2orf27B Gene

Paralogs for C2orf27B Gene

genes like me logo Genes that share paralogs with C2orf27B: view

Variants for C2orf27B Gene

Sequence variations from dbSNP and Humsavar for C2orf27B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000073805 -- 131,801,557(-) G/A 5_prime_UTR_variant
rs1000489241 -- 131,801,730(-) G/A upstream_transcript_variant
rs1001539488 -- 131,801,986(-) C/T upstream_transcript_variant
rs1001590171 -- 131,802,110(-) G/A upstream_transcript_variant
rs1001875173 -- 131,801,021(-) C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf27B Gene

Variant ID Type Subtype PubMed ID
esv26126 CNV gain 19812545
esv2759092 CNV gain+loss 17122850
esv2762852 CNV gain 21179565
esv3592494 CNV gain 21293372
nsv1077893 CNV duplication 25765185
nsv1078893 OTHER inversion 25765185
nsv1115576 CNV duplication 24896259
nsv1125312 OTHER inversion 24896259
nsv1148936 CNV duplication 26484159
nsv1152544 OTHER inversion 26484159
nsv428404 CNV loss 18775914
nsv482055 CNV gain 20164927
nsv7328 OTHER inversion 18451855
nsv961889 CNV duplication 23825009
nsv963853 CNV duplication 23825009
nsv997248 CNV loss 25217958

Variation tolerance for C2orf27B Gene

Gene Damage Index Score: 0.08; 1.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf27B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf27B Gene

Disorders for C2orf27B Gene

Additional Disease Information for C2orf27B

No disorders were found for C2orf27B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf27B Gene

Publications for C2orf27B Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B … Wanker EE (Nucleic acids research 2013) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for C2orf27B Gene

Sources for C2orf27B Gene

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