Aliases for C2orf27A Gene

RNA type for C2orf27A Gene

lncRNA

Aliases for C2orf27A Gene

External Ids for C2orf27A Gene

Previous HGNC Symbols for C2orf27A Gene

  • C2orf27

Previous GeneCards Identifiers for C2orf27A Gene

  • GC02P132197
  • GC02P132479
  • GC02P124473
  • GC02P131722
  • GC02P132756
  • GC02P133060

Summaries for C2orf27A Gene

GeneCards Summary for C2orf27A Gene

C2orf27A (Chromosome 2 Open Reading Frame 27A) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with C2orf27A include Common Wart and Ebola Hemorrhagic Fever. An important paralog of this gene is C2orf27B.

Additional gene information for C2orf27A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C2orf27A Gene

Genomics for C2orf27A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C2orf27A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J131681 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 0.3 +36.6 36648 6.5 SP1 MYC ZNF600 ZNF580 KLF9 POLR2A ZNF223 MXD4 KLF11 TBP HSALNG0018917 NBEAP2 TOMM40P4 HSALNG0018916 C2orf27A CCDC74A ANKRD30BL
GH02J131672 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 0.4 +24.6 24643 0.4 ZNF654 KLF9 NFIC ZIC2 REST TRIM22 ZNF341 ZFP64 CTCF ZNF217 AB372632-006 HSALNG0018915 piR-52457-006 FAM168B NBEAP2 C2orf27A LINC01087 CCDC74A ANKRD30BL
GH02J131667 Enhancer 1.1 FANTOM5 ENCODE 0.4 +21.3 21295 2.6 ZNF207 NCOR1 IKZF1 ZNF592 NFIC REST ZEB1 NR2C1 ZNF217 ARNT piR-52457-006 NBEAP2 CCDC74A piR-58716-004 C2orf27A LINC01087 ANKRD30BL
GH02J131640 Enhancer 0.9 ENCODE 0.4 -6.4 -6409 1.4 IKZF1 NCOR1 ZNF592 MNT ARNT TAF9B FOXA2 NBN TAL1 ELF1 NBEAP2 SMPD4BP piR-54397-003 C2orf27A LINC01087 CCDC74A ANKRD30BL
GH02J131643 Enhancer 0.5 Ensembl 0.7 -4.6 -4590 0.8 IKZF1 NFE2 HDAC2 MAFG KDM1A HDAC1 C2orf27A piR-54397-003 LINC01087 CCDC74A ANKRD30BL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C2orf27A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C2orf27A

Top Transcription factor binding sites by QIAGEN in the C2orf27A gene promoter:
  • AML1a
  • HOXA9
  • HOXA9B
  • IRF-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-4a

Genomic Locations for C2orf27A Gene

Latest Assembly
chr2:131,647,990-131,767,404
(GRCh38/hg38)
Size:
119,415 bases
Orientation:
Plus strand

Previous Assembly
chr2:132,440,072-132,524,977
(GRCh37/hg19 by Entrez Gene)
Size:
84,906 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr2(ALT_REF_LOCI_1):1-71,290 (+)

Genomic View for C2orf27A Gene

Genes around C2orf27A on UCSC Golden Path with GeneCards custom track
C2orf27A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
C2orf27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf27A Gene

Proteins for C2orf27A Gene

  • Protein details for C2orf27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DPF5-CB27A_HUMAN
    Recommended name:
    Uncharacterized protein C2orf27A
    Protein Accession:
    P0DPF5
    Secondary Accessions:
    • O43575
    • Q2M1X0
    • Q52M10
    • Q580R0
    • Q86XG2

    Protein attributes for C2orf27A Gene

    Size:
    203 amino acids
    Molecular mass:
    21517 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf27A Gene

Post-translational modifications for C2orf27A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf27A Gene

Domains & Families for C2orf27A Gene

Suggested Antigen Peptide Sequences for C2orf27A Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 2 open reading frame 27, isoform CRA_a (D3DP68_HUMAN)

No data available for Gene Families , Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C2orf27A Gene

Function for C2orf27A Gene

Phenotypes From GWAS Catalog for C2orf27A Gene

genes like me logo Genes that share phenotypes with C2orf27A: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf27A Gene

Localization for C2orf27A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf27A gene
Compartment Confidence
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C2orf27A Gene

Pathways & Interactions for C2orf27A Gene

PathCards logo

SuperPathways for C2orf27A Gene

No Data Available

Gene Ontology (GO) - Biological Process for C2orf27A Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for C2orf27A Gene

Drugs & Compounds for C2orf27A Gene

No Compound Related Data Available

Transcripts for C2orf27A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for C2orf27A Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000EF6DF6_9606 lncRNA 4558 1

Ensembl: ENST00000655714 (view in UCSC) ,

URS0001BBE41A_9606 lncRNA 3981 1

RefSeq: NR_149016,

URS0000EEFC63_9606 lncRNA 3710 1

Ensembl: ENST00000653458 (view in UCSC) ,

URS0001BBE3BD_9606 lncRNA 3550 1

RefSeq: NR_149014,

URS0001BBE531_9606 lncRNA 3504 1

RefSeq: NR_149015,

C2orf27A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for C2orf27A Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C2orf27A

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf27A Gene

No ASD Table

Relevant External Links for C2orf27A Gene

GeneLoc Exon Structure for
C2orf27A

Expression for C2orf27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C2orf27A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf27A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C2orf27A

SOURCE GeneReport for Unigene cluster for C2orf27A Gene:

Hs.655680

Evidence on tissue expression from TISSUES for C2orf27A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with C2orf27A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf27A Gene

Orthologs for C2orf27A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C2orf27A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100615918 29
  • 97.11 (n)
Species where no ortholog for C2orf27A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C2orf27A Gene

ENSEMBL:
Gene Tree for C2orf27A (if available)
TreeFam:
Gene Tree for C2orf27A (if available)
Alliance of Genome Resources:
Additional Orthologs for C2orf27A

Paralogs for C2orf27A Gene

Paralogs for C2orf27A Gene

genes like me logo Genes that share paralogs with C2orf27A: view

Variants for C2orf27A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C2orf27A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C2orf27A Gene

Variant ID Type Subtype PubMed ID
dgv2247e59 CNV duplication 20981092
esv24587 CNV gain+loss 19812545
esv26126 CNV gain 19812545
esv2759092 CNV gain+loss 17122850
esv2762850 CNV gain 21179565
esv3592492 CNV gain 21293372
esv3592493 CNV loss 21293372
esv3592494 CNV gain 21293372
nsv1011966 CNV loss 25217958
nsv10186 CNV loss 18304495
nsv1072033 CNV deletion 25765185
nsv1132513 CNV duplication 24896259
nsv1139737 CNV duplication 24896259
nsv1151957 CNV duplication 26484159
nsv428404 CNV loss 18775914
nsv471420 CNV gain 19718026
nsv482054 CNV gain 20164927
nsv514979 CNV gain 21397061
nsv527590 CNV loss 19592680
nsv583146 CNV gain 21841781
nsv820012 CNV loss 19587683
nsv834377 CNV gain 17160897
nsv953174 CNV duplication 24416366
nsv953175 CNV duplication 24416366
nsv953176 CNV deletion 24416366
nsv961656 CNV duplication 23825009
nsv961888 CNV duplication 23825009
nsv961889 CNV duplication 23825009
nsv963725 CNV duplication 23825009
nsv997248 CNV loss 25217958
nsv999735 CNV gain 25217958

Additional Variant Information for C2orf27A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf27A
Leiden Open Variation Database (LOVD)
C2orf27A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for C2orf27A Gene

Disorders for C2orf27A Gene

MalaCards: The human disease database

(3) MalaCards diseases for C2orf27A Gene - From: COP

Disorder Aliases PubMed IDs
common wart
ebola hemorrhagic fever
  • ebola virus disease
benign epilepsy with centrotemporal spikes
  • bcects
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C2orf27A

genes like me logo Genes that share disorders with C2orf27A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C2orf27A Gene

Publications for C2orf27A Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3
  5. Preliminary RNA-Seq Analysis of Long Non-Coding RNAs Expressed in Human Term Placenta. (PMID: 29954144) Majewska M … Majewski MK (International journal of molecular sciences 2018) 3

Products for C2orf27A Gene

Sources for C2orf27A Gene