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Aliases for C2orf27A Gene

Aliases for C2orf27A Gene

  • Chromosome 2 Open Reading Frame 27A 2 3 5
  • Chromosome 2 Open Reading Frame 27 2
  • Uncharacterized Protein C2orf27A 3
  • Uncharacterized Protein C2orf27 3
  • C2orf27B 3
  • C2orf27 3

External Ids for C2orf27A Gene

Previous HGNC Symbols for C2orf27A Gene

  • C2orf27

Previous GeneCards Identifiers for C2orf27A Gene

  • GC02P132197
  • GC02P132479
  • GC02P124473

Summaries for C2orf27A Gene

GeneCards Summary for C2orf27A Gene

C2orf27A (Chromosome 2 Open Reading Frame 27A) is a Protein Coding gene. An important paralog of this gene is C2orf27B.

Additional gene information for C2orf27A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf27A Gene

Genomics for C2orf27A Gene

GeneHancer (GH) Regulatory Elements for C2orf27A Gene

Promoters and enhancers for C2orf27A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J131724 Promoter 0.5 Ensembl 660.1 +1.9 1926 0.2 C2orf27A ENSG00000213222 LOC100422473 NBEAP2
GH02J131719 Enhancer 0.4 ENCODE 663.8 -0.9 -932 3.3 HLF CEBPB PPARG C2orf27A NBEAP2 ENSG00000213222 MZT2A PIR46456
GH02J131681 Enhancer 1.2 Ensembl ENCODE 38.2 -37.6 -37637 6.3 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF416 ZNF143 C2orf27A ENSG00000213222 PIR46456
GH02J131667 Enhancer 1.4 FANTOM5 Ensembl ENCODE 24.4 -53.1 -53090 2.6 PKNOX1 ATF1 ARNT ZNF280A TCF12 ZNF207 ZNF143 ZFP91 FOS ATF7 PIR46456 C2orf27A PIR51363
GH02J132264 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 +547.2 547178 9.7 HDGF PKNOX1 SMAD1 ARNT ZFP64 NEUROD1 SIN3A YBX1 ZBTB7B YY1 LOC105373622 LOC150776 ENSG00000272769 ZNF806 FAM201B ENSG00000213222 CCDC74A C2orf27A GC02P132278
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C2orf27A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C2orf27A gene promoter:
  • Pax-4a
  • Meis-1b
  • Meis-1a
  • Meis-1
  • IRF-1
  • AML1a
  • HOXA9
  • HOXA9B

Genomic Locations for C2orf27A Gene

Genomic Locations for C2orf27A Gene
chr2:131,722,375-131,767,404
(GRCh38/hg38)
Size:
45,030 bases
Orientation:
Plus strand
chr2:132,479,948-132,524,977
(GRCh37/hg19)
Size:
45,030 bases
Orientation:
Plus strand

Genomic View for C2orf27A Gene

Genes around C2orf27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf27A Gene

Proteins for C2orf27A Gene

  • Protein details for C2orf27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DPF5-CB27A_HUMAN
    Recommended name:
    Uncharacterized protein C2orf27A
    Protein Accession:
    P0DPF5
    Secondary Accessions:
    • O43575
    • Q2M1X0
    • Q52M10
    • Q580R0
    • Q86XG2

    Protein attributes for C2orf27A Gene

    Size:
    203 amino acids
    Molecular mass:
    21517 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf27A Gene

Post-translational modifications for C2orf27A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf27A Gene

No data available for DME Specific Peptides for C2orf27A Gene

Domains & Families for C2orf27A Gene

Protein Domains for C2orf27A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C2orf27A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf27A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C2orf27A Gene

Function for C2orf27A Gene

Phenotypes From GWAS Catalog for C2orf27A Gene

genes like me logo Genes that share phenotypes with C2orf27A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf27A Gene

Localization for C2orf27A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf27A gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C2orf27A Gene

Pathways & Interactions for C2orf27A Gene

SuperPathways for C2orf27A Gene

No Data Available

Interacting Proteins for C2orf27A Gene

Gene Ontology (GO) - Biological Process for C2orf27A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf27A Gene

Drugs & Compounds for C2orf27A Gene

No Compound Related Data Available

Transcripts for C2orf27A Gene

mRNA/cDNA for C2orf27A Gene

Unigene Clusters for C2orf27A Gene

Chromosome 2 open reading frame 27A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf27A Gene

No ASD Table

Relevant External Links for C2orf27A Gene

GeneLoc Exon Structure for
C2orf27A
ECgene alternative splicing isoforms for
C2orf27A

Expression for C2orf27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf27A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf27A Gene



NURSA nuclear receptor signaling pathways regulating expression of C2orf27A Gene:

C2orf27A

SOURCE GeneReport for Unigene cluster for C2orf27A Gene:

Hs.655680

Evidence on tissue expression from TISSUES for C2orf27A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with C2orf27A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf27A Gene

Orthologs for C2orf27A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C2orf27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615918 33
  • 97.11 (n)
-- 34
  • 92 (a)
OneToMany
Species where no ortholog for C2orf27A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf27A Gene

ENSEMBL:
Gene Tree for C2orf27A (if available)
TreeFam:
Gene Tree for C2orf27A (if available)

Paralogs for C2orf27A Gene

Paralogs for C2orf27A Gene

genes like me logo Genes that share paralogs with C2orf27A: view

Variants for C2orf27A Gene

Sequence variations from dbSNP and Humsavar for C2orf27A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000052761 -- 131,746,991(+) C/T intron_variant
rs1000133308 -- 131,739,778(+) G/C intron_variant
rs1000230514 -- 131,740,144(+) A/G intron_variant
rs1000417858 -- 131,760,563(+) A/G intron_variant
rs1000751242 -- 131,759,464(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf27A Gene

Variant ID Type Subtype PubMed ID
dgv2247e59 CNV duplication 20981092
esv24587 CNV gain+loss 19812545
esv26126 CNV gain 19812545
esv2759092 CNV gain+loss 17122850
esv2762850 CNV gain 21179565
esv3592492 CNV gain 21293372
esv3592493 CNV loss 21293372
esv3592494 CNV gain 21293372
nsv1011966 CNV loss 25217958
nsv10186 CNV loss 18304495
nsv1072033 CNV deletion 25765185
nsv1132513 CNV duplication 24896259
nsv1139737 CNV duplication 24896259
nsv1151957 CNV duplication 26484159
nsv428404 CNV loss 18775914
nsv471420 CNV gain 19718026
nsv482054 CNV gain 20164927
nsv514979 CNV gain 21397061
nsv527590 CNV loss 19592680
nsv583146 CNV gain 21841781
nsv820012 CNV loss 19587683
nsv834377 CNV gain 17160897
nsv953174 CNV duplication 24416366
nsv953175 CNV duplication 24416366
nsv953176 CNV deletion 24416366
nsv961656 CNV duplication 23825009
nsv961888 CNV duplication 23825009
nsv961889 CNV duplication 23825009
nsv963725 CNV duplication 23825009
nsv997248 CNV loss 25217958
nsv999735 CNV gain 25217958

Additional Variant Information for C2orf27A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf27A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for C2orf27A Gene

Disorders for C2orf27A Gene

Additional Disease Information for C2orf27A

No disorders were found for C2orf27A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf27A Gene

Publications for C2orf27A Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C2orf27A Gene

Sources for C2orf27A Gene

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