Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C2orf16 Gene

Aliases for C2orf16 Gene

  • Chromosome 2 Open Reading Frame 16 2 3 5
  • P-S-E-R-S-H-H-S Repeats Containing 2

External Ids for C2orf16 Gene

Previous GeneCards Identifiers for C2orf16 Gene

  • GC02P027777
  • GC02P027714
  • GC02P027652
  • GC02P027799
  • GC02P027541
  • GC02P027577

Summaries for C2orf16 Gene

GeneCards Summary for C2orf16 Gene

C2orf16 (Chromosome 2 Open Reading Frame 16) is a Protein Coding gene.

Additional gene information for C2orf16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf16 Gene

Genomics for C2orf16 Gene

GeneHancer (GH) Regulatory Elements for C2orf16 Gene

Promoters and enhancers for C2orf16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I027719 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +183.4 183362 2.5 SIN3A GLI4 ZNF2 BRCA1 ZNF416 ATF7 FOS KLF13 SP3 REST SUPT7L CAD ZNF512 EIF2B4 GPN1 GTF3C2 ZNF513 AGBL5 GTF3C2-AS1 LOC105374363
GH02I027407 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 5.9 -128.2 -128204 2.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 PPM1G SNX17 SUPT7L ZNF512 GTF3C2 NRBP1 IFT172 TMEM214 CAD LOC105374363
GH02I027680 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.6 +145.2 145191 3.5 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 ARID2 ZNF207 ZNF143 LINC01460 SLC4A1AP CCDC121 GPN1 ZNF512 C2orf16 SUPT7L LOC105374378 GC02M027478
GH02I027953 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +419.8 419847 8.5 PKNOX1 MLX SIN3A YY1 FOS RUNX3 REST PPARG NFIL3 SSRP1 FOSL2 RBKS FLJ31356 FNDC4 C2orf16 CGREF1 LINC01460 BABAM2 GCKR LOC100422227
GH02I027622 Enhancer 0.6 ENCODE dbSUPER 9.9 +85.4 85370 1.1 JUND POLR2A C2orf16 GPN1 ZNF512 ENSG00000259080 GC02M027478
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C2orf16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C2orf16 gene promoter:

Genomic Locations for C2orf16 Gene

Genomic Locations for C2orf16 Gene
45,337 bases
Plus strand

Genomic View for C2orf16 Gene

Genes around C2orf16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf16 Gene

Proteins for C2orf16 Gene

  • Protein details for C2orf16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C2orf16
    Protein Accession:
    Secondary Accessions:
    • B9EIQ4
    • Q53S01
    • Q8ND64
    • Q9H088

    Protein attributes for C2orf16 Gene

    1984 amino acids
    Molecular mass:
    224321 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAX93198.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for C2orf16 Gene

Post-translational modifications for C2orf16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf16 Gene

Domains & Families for C2orf16 Gene

Gene Families for C2orf16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C2orf16 Gene


Suggested Antigen Peptide Sequences for C2orf16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The P-S-E-R-S-H-H-S repeats give rise to an antiparallel beta-structure.
  • The P-S-E-R-S-H-H-S repeats give rise to an antiparallel beta-structure.
genes like me logo Genes that share domains with C2orf16: view

Function for C2orf16 Gene

Phenotypes From GWAS Catalog for C2orf16 Gene

genes like me logo Genes that share phenotypes with C2orf16: view

miRNA for C2orf16 Gene

miRTarBase miRNAs that target C2orf16

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf16 Gene

Localization for C2orf16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf16 gene
Compartment Confidence
extracellular 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C2orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with C2orf16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C2orf16 Gene

Pathways & Interactions for C2orf16 Gene

SuperPathways for C2orf16 Gene

No Data Available

Interacting Proteins for C2orf16 Gene

Gene Ontology (GO) - Biological Process for C2orf16 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf16 Gene

Drugs & Compounds for C2orf16 Gene

No Compound Related Data Available

Transcripts for C2orf16 Gene

mRNA/cDNA for C2orf16 Gene

Unigene Clusters for C2orf16 Gene

Chromosome 2 open reading frame 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf16 Gene

No ASD Table

Relevant External Links for C2orf16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf16 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf16 Gene

This gene is overexpressed in Testis (x33.6).

NURSA nuclear receptor signaling pathways regulating expression of C2orf16 Gene:


SOURCE GeneReport for Unigene cluster for C2orf16 Gene:

genes like me logo Genes that share expression patterns with C2orf16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf16 Gene

Orthologs for C2orf16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C2AH2orf16 33
  • 98.96 (n)
C2orf16 34
  • 96 (a)
(Canis familiaris)
Mammalia LOC102156387 33
  • 80.19 (n)
cfa-mir-1837-2 34 34
  • 60 (a)
(Bos Taurus)
Mammalia C11H2orf16 33
  • 78.38 (n)
C2orf16 34
  • 62 (a)
(Mus musculus)
Mammalia LOC102635990 33
  • 68.68 (n)
4932415D10Rik 34
  • 56 (a)
Gm17695 16
(Rattus norvegicus)
Mammalia LOC100359615 33
  • 68.32 (n)
Species where no ortholog for C2orf16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf16 Gene

Gene Tree for C2orf16 (if available)
Gene Tree for C2orf16 (if available)

Paralogs for C2orf16 Gene Pseudogenes for C2orf16 Gene

genes like me logo Genes that share paralogs with C2orf16: view

No data available for Paralogs for C2orf16 Gene

Variants for C2orf16 Gene

Sequence variations from dbSNP and Humsavar for C2orf16 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000435539 -- 27,580,063(+) T/C coding_sequence_variant, missense_variant
rs1000952218 -- 27,576,659(+) G/T coding_sequence_variant, missense_variant
rs1001848423 -- 27,575,522(+) T/C upstream_transcript_variant
rs1002402187 -- 27,575,144(+) G/C/T upstream_transcript_variant
rs1002901367 -- 27,581,282(+) T/A/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf16 Gene

Variant ID Type Subtype PubMed ID
nsv471937 CNV novel sequence insertion 20440878
nsv817684 CNV gain 17921354

Variation tolerance for C2orf16 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.74; 91.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf16 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf16 Gene

Disorders for C2orf16 Gene

Additional Disease Information for C2orf16

No disorders were found for C2orf16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf16 Gene

Publications for C2orf16 Gene

  1. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. (PMID: 21386085) Kraja AT … Borecki IB (Diabetes 2011) 3 44 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu JH … Mozaffarian D (Circulation. Cardiovascular genetics 2013) 3 58
  5. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D … Pajukanta P (Journal of medical genetics 2013) 3 58

Products for C2orf16 Gene

Sources for C2orf16 Gene

Loading form....