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Aliases for C2orf15 Gene

Aliases for C2orf15 Gene

  • Chromosome 2 Open Reading Frame 15 2 3 5

External Ids for C2orf15 Gene

Previous GeneCards Identifiers for C2orf15 Gene

  • GC02P099379
  • GC02P099216
  • GC02P099757
  • GC02P093523

Summaries for C2orf15 Gene

GeneCards Summary for C2orf15 Gene

C2orf15 (Chromosome 2 Open Reading Frame 15) is a Protein Coding gene. Diseases associated with C2orf15 include Retinitis Pigmentosa 4.

Additional gene information for C2orf15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf15 Gene

Genomics for C2orf15 Gene

GeneHancer (GH) Regulatory Elements for C2orf15 Gene

Promoters and enhancers for C2orf15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I099140 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.2 -160 2.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 SP3 TSGA10 C2orf15 ENSG00000241962 LOC550644
GH02I098767 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.4 -370.8 -370810 6.1 FOXA2 NFIB ARID4B DMAP1 ZSCAN9 RFX5 RARA ZNF548 CREM IKZF2 MGAT4A ENSG00000273306 REV1 MITD1 TMEM131 LOC550644 UNC50 TSGA10 LYG1 INPP4A
GH02I098757 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 3.7 -381.8 -381771 4.6 HDGF PKNOX1 JUN EBF1 BMI1 BATF IRF4 RELA CTBP1 GATA3 KIAA1211L LYG1 C2orf15 MGAT4A INPP4A UNC50 LOC101927070
GH02I098765 Enhancer 0.9 ENCODE dbSUPER 4.1 -374.9 -374946 1.3 ELF3 SOX13 SAP130 CEBPG RARA RELA TEAD3 NR2F6 IKZF2 RUNX3 TSGA10 LYG1 C2orf15 LOC101927070 MGAT4A
GH02I098714 Enhancer 0.6 dbSUPER 4.1 -424.6 -424627 5.6 CBFB NR2F1 ZBED1 TRIM22 JUNB DPF2 ZNF121 ZNF217 NFATC1 IKZF2 C2orf15 MGAT4A YWHAQP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C2orf15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C2orf15 gene promoter:

Genomic Locations for C2orf15 Gene

Genomic Locations for C2orf15 Gene
chr2:99,141,485-99,151,487
(GRCh38/hg38)
Size:
10,003 bases
Orientation:
Plus strand
chr2:99,757,948-99,939,204
(GRCh37/hg19)

Genomic View for C2orf15 Gene

Genes around C2orf15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf15 Gene

Proteins for C2orf15 Gene

  • Protein details for C2orf15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU43-CB015_HUMAN
    Recommended name:
    Uncharacterized protein C2orf15
    Protein Accession:
    Q8WU43

    Protein attributes for C2orf15 Gene

    Size:
    125 amino acids
    Molecular mass:
    13691 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf15 Gene

Post-translational modifications for C2orf15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf15 Gene

Domains & Families for C2orf15 Gene

Gene Families for C2orf15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C2orf15 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf15: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf15 Gene

Function for C2orf15 Gene

Phenotypes From GWAS Catalog for C2orf15 Gene

Gene Ontology (GO) - Molecular Function for C2orf15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
genes like me logo Genes that share ontologies with C2orf15: view
genes like me logo Genes that share phenotypes with C2orf15: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf15 Gene

Localization for C2orf15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf15 gene
Compartment Confidence
mitochondrion 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C2orf15 Gene

Pathways & Interactions for C2orf15 Gene

SuperPathways for C2orf15 Gene

No Data Available

Interacting Proteins for C2orf15 Gene

Gene Ontology (GO) - Biological Process for C2orf15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf15 Gene

Drugs & Compounds for C2orf15 Gene

No Compound Related Data Available

Transcripts for C2orf15 Gene

mRNA/cDNA for C2orf15 Gene

Unigene Clusters for C2orf15 Gene

Chromosome 2 open reading frame 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf15 Gene

No ASD Table

Relevant External Links for C2orf15 Gene

GeneLoc Exon Structure for
C2orf15
ECgene alternative splicing isoforms for
C2orf15

Expression for C2orf15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf15 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf15 Gene

This gene is overexpressed in Pituitary (x4.6).

Protein differential expression in normal tissues from HIPED for C2orf15 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf15 Gene



Protein tissue co-expression partners for C2orf15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C2orf15 Gene:

C2orf15

SOURCE GeneReport for Unigene cluster for C2orf15 Gene:

Hs.352211

Evidence on tissue expression from TISSUES for C2orf15 Gene

  • Nervous system(4.8)
  • Kidney(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with C2orf15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf15 Gene

Orthologs for C2orf15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf15 33
  • 98.93 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 64 (a)
OneToOne
Species where no ortholog for C2orf15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf15 Gene

ENSEMBL:
Gene Tree for C2orf15 (if available)
TreeFam:
Gene Tree for C2orf15 (if available)

Paralogs for C2orf15 Gene

No data available for Paralogs for C2orf15 Gene

Variants for C2orf15 Gene

Sequence variations from dbSNP and Humsavar for C2orf15 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000789496 -- 99,142,979(+) T/C intron_variant
rs1001179458 -- 99,150,165(+) G/T intron_variant
rs1001272569 -- 99,150,310(+) A/G intron_variant
rs1001427931 -- 99,141,492(+) G/A upstream_transcript_variant
rs1001666055 -- 99,147,433(+) T/G 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf15 Gene

Variant ID Type Subtype PubMed ID
esv3591732 CNV gain 21293372

Variation tolerance for C2orf15 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf15 Gene

Disorders for C2orf15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C2orf15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 4
  • rp4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C2orf15

genes like me logo Genes that share disorders with C2orf15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C2orf15 Gene

Publications for C2orf15 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz AG … Landthaler M (Molecular cell 2012) 3 58
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C2orf15 Gene

Sources for C2orf15 Gene

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