Aliases for C2orf16 Gene

Aliases for C2orf16 Gene

  • Chromosome 2 Open Reading Frame 16 2 3 5
  • P-S-E-R-S-H-H-S Repeats Containing 2 3
  • Uncharacterized Protein C2orf16 3 4
  • DKFZp434G118 2
  • C2orf16 5

External Ids for C2orf16 Gene

Previous GeneCards Identifiers for C2orf16 Gene

  • GC02P027777
  • GC02P027714
  • GC02P027652
  • GC02P027799
  • GC02P027541
  • GC02P027577
  • GC02P027538

Summaries for C2orf16 Gene

GeneCards Summary for C2orf16 Gene

C2orf16 (Chromosome 2 Open Reading Frame 16) is a Protein Coding gene.

Additional gene information for C2orf16 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C2orf16 Gene

Genomics for C2orf16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C2orf16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J027719 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11.2 +183.4 183362 2.5 HNRNPL CREB1 PRDM10 ZNF629 ZNF692 JUND PRDM1 ZIC2 ZSCAN4 ZNF24 SUPT7L CAD ZNF512 EIF2B4 GPN1 GTF3C2 ZNF513 AGBL5 GTF3C2-AS1 ENSG00000234072
GH02J027407 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.9 -128.3 -128285 3 BRCA1 RNF2 ARHGAP35 SP1 GATAD2A CTCF ZBTB33 PRDM10 ZNF629 TFE3 PPM1G RF00017-3145 lnc-NRBP1-2 SNX17 ZNF512 SUPT7L CAD IFT172 GPN1 KRTCAP3
GH02J027680 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.6 +146.8 146846 6.9 CREB1 GATAD2A CTCF TEAD4 ZNF512 KDM1A JUND PRDM1 ZNF143 PKNOX1 SLC4A1AP SUPT7L LINC01460 CCDC121 GPN1 ZNF512 C2orf16 KRTCAP3 OST4 lnc-MRPL33-1
GH02J027622 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE dbSUPER 9.9 +85.6 85617 1.6 SCRT2 JUND JUN TAF1 POLR2A GPN1 SNX17 C2orf16 piR-49423-126 ENSG00000259080 ZNF512
GH02J027958 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 5.9 +422.5 422541 3.1 RNF2 GATAD2A ZNF512 RCOR2 SOX6 CEBPA SOX13 CEBPB SP1 JUND FOSL2 FLJ31356 FNDC4 RBKS C2orf16 CGREF1 GCKR LOC100422227 piR-56341-100 BABAM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C2orf16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C2orf16

Top Transcription factor binding sites by QIAGEN in the C2orf16 gene promoter:
  • AML1a
  • Cdc5
  • FOXD1
  • LCR-F1
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox5
  • STAT5B
  • USF1
  • XBP-1

Genomic Locations for C2orf16 Gene

Genomic Locations for C2orf16 Gene
chr2:27,537,386-27,582,722
(GRCh38/hg38)
Size:
45,337 bases
Orientation:
Plus strand
chr2:27,799,389-27,805,589
(GRCh37/hg19)
Size:
6,201 bases
Orientation:
Plus strand

Genomic View for C2orf16 Gene

Genes around C2orf16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf16 Gene

Proteins for C2orf16 Gene

  • Protein details for C2orf16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DN1-CB016_HUMAN
    Recommended name:
    Uncharacterized protein C2orf16
    Protein Accession:
    Q68DN1
    Secondary Accessions:
    • B9EIQ4
    • Q53S01
    • Q8ND64
    • Q9H088

    Protein attributes for C2orf16 Gene

    Size:
    1984 amino acids
    Molecular mass:
    224321 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93198.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for C2orf16 Gene

Post-translational modifications for C2orf16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf16 Gene

Domains & Families for C2orf16 Gene

Gene Families for C2orf16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C2orf16 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C2orf16 Gene

GenScript: Design optimal peptide antigens:
  • C2orf16 protein (A4QMX9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q68DN1

UniProtKB/Swiss-Prot:

CB016_HUMAN :
  • The P-S-E-R-S-H-H-S repeats give rise to an antiparallel beta-structure.
Domain:
  • The P-S-E-R-S-H-H-S repeats give rise to an antiparallel beta-structure.
genes like me logo Genes that share domains with C2orf16: view

Function for C2orf16 Gene

Phenotypes From GWAS Catalog for C2orf16 Gene

genes like me logo Genes that share phenotypes with C2orf16: view

Animal Model Products

CRISPR Products

miRNA for C2orf16 Gene

miRTarBase miRNAs that target C2orf16

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C2orf16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf16 Gene

Localization for C2orf16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf16 gene
Compartment Confidence
nucleus 5
extracellular 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C2orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with C2orf16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C2orf16 Gene

Pathways & Interactions for C2orf16 Gene

PathCards logo

SuperPathways for C2orf16 Gene

No Data Available

Interacting Proteins for C2orf16 Gene

Selected Interacting proteins: Q68DN1-CB016_HUMAN for C2orf16 Gene via IID

Symbol External ID(s) Details
MYC

Gene Ontology (GO) - Biological Process for C2orf16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf16 Gene

Drugs & Compounds for C2orf16 Gene

No Compound Related Data Available

Transcripts for C2orf16 Gene

mRNA/cDNA for C2orf16 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C2orf16

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf16 Gene

No ASD Table

Relevant External Links for C2orf16 Gene

GeneLoc Exon Structure for
C2orf16

Expression for C2orf16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C2orf16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for C2orf16 Gene

This gene is overexpressed in Testis (x33.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C2orf16

SOURCE GeneReport for Unigene cluster for C2orf16 Gene:

Hs.131021
genes like me logo Genes that share expression patterns with C2orf16: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf16 Gene

Orthologs for C2orf16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf16 30
  • 98.96 (n)
C2orf16 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC102156387 30
  • 80.19 (n)
cfa-mir-1837-2 31 31
  • 62 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia C11H2orf16 30
  • 78.38 (n)
C2orf16 31
  • 62 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia LOC102635990 30
  • 68.68 (n)
4932415D10Rik 17 31
  • 56 (a)
OneToOne
Gm17434 17
Gm17695 17
Rat
(Rattus norvegicus)
Mammalia LOC100359615 30
  • 68.32 (n)
Species where no ortholog for C2orf16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C2orf16 Gene

ENSEMBL:
Gene Tree for C2orf16 (if available)
TreeFam:
Gene Tree for C2orf16 (if available)

Paralogs for C2orf16 Gene

Pseudogenes.org Pseudogenes for C2orf16 Gene

genes like me logo Genes that share paralogs with C2orf16: view

No data available for Paralogs for C2orf16 Gene

Variants for C2orf16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C2orf16 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs12618071 - p.Ser1500Phe
rs13031957 - p.Asn1613Ser
rs13392197 - p.His1559Tyr
rs13410886 - p.Asp505Val
rs13416968 - p.Ile767Thr

Additional dbSNP identifiers (rs#s) for C2orf16 Gene

Structural Variations from Database of Genomic Variants (DGV) for C2orf16 Gene

Variant ID Type Subtype PubMed ID
nsv471937 CNV novel sequence insertion 20440878
nsv817684 CNV gain 17921354

Variation tolerance for C2orf16 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.74; 91.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf16 Gene

Human Gene Mutation Database (HGMD)
C2orf16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf16 Gene

Disorders for C2orf16 Gene

Additional Disease Information for C2orf16

No disorders were found for C2orf16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf16 Gene

Publications for C2orf16 Gene

  1. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. (PMID: 21386085) Kraja AT … Borecki IB (Diabetes 2011) 3 41
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
  4. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D … Pajukanta P (Journal of medical genetics 2013) 3
  5. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu JH … Mozaffarian D (Circulation. Cardiovascular genetics 2013) 3

Products for C2orf16 Gene

Sources for C2orf16 Gene