Aliases for C2CD4D Gene

Aliases for C2CD4D Gene

  • C2 Calcium Dependent Domain Containing 4D 2 3 5
  • FAM148D 2 3 4
  • C2 Calcium-Dependent Domain-Containing Protein 4D 3 4
  • Family With Sequence Similarity 148, Member D 2 3
  • C2CD4D 5

External Ids for C2CD4D Gene

Previous GeneCards Identifiers for C2CD4D Gene

  • GC01M151810
  • GC01M123187

Summaries for C2CD4D Gene

GeneCards Summary for C2CD4D Gene

C2CD4D (C2 Calcium Dependent Domain Containing 4D) is a Protein Coding gene. An important paralog of this gene is C2CD4C.

Additional gene information for C2CD4D Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C2CD4D Gene

Genomics for C2CD4D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C2CD4D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C2CD4D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C2CD4D

Genomic Locations for C2CD4D Gene

Genomic Locations for C2CD4D Gene
chr1:151,837,818-151,840,557
(GRCh38/hg38)
Size:
2,740 bases
Orientation:
Minus strand
chr1:151,810,295-151,813,033
(GRCh37/hg19)
Size:
2,739 bases
Orientation:
Minus strand

Genomic View for C2CD4D Gene

Genes around C2CD4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2CD4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2CD4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2CD4D Gene

Proteins for C2CD4D Gene

  • Protein details for C2CD4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B7Z1M9-C2D4D_HUMAN
    Recommended name:
    C2 calcium-dependent domain-containing protein 4D
    Protein Accession:
    B7Z1M9
    Secondary Accessions:
    • B2RXG8

    Protein attributes for C2CD4D Gene

    Size:
    353 amino acids
    Molecular mass:
    37583 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2CD4D Gene

Post-translational modifications for C2CD4D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2CD4D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2CD4D Gene

Domains & Families for C2CD4D Gene

Gene Families for C2CD4D Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C2CD4D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2CD4D Gene

GenScript: Design optimal peptide antigens:
  • C2 calcium-dependent domain-containing protein 4D (C2D4D_HUMAN)
genes like me logo Genes that share domains with C2CD4D: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C2CD4D Gene

Function for C2CD4D Gene

Phenotypes From GWAS Catalog for C2CD4D Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C2CD4D

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2CD4D Gene

Localization for C2CD4D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2CD4D gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C2CD4D Gene

Pathways & Interactions for C2CD4D Gene

PathCards logo

SuperPathways for C2CD4D Gene

No Data Available

Interacting Proteins for C2CD4D Gene

Gene Ontology (GO) - Biological Process for C2CD4D Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2CD4D Gene

Drugs & Compounds for C2CD4D Gene

No Compound Related Data Available

Transcripts for C2CD4D Gene

mRNA/cDNA for C2CD4D Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C2CD4D

Alternative Splicing Database (ASD) splice patterns (SP) for C2CD4D Gene

No ASD Table

Relevant External Links for C2CD4D Gene

GeneLoc Exon Structure for
C2CD4D

Expression for C2CD4D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C2CD4D Gene

mRNA differential expression in normal tissues according to GTEx for C2CD4D Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.8) and Skin - Not Sun Exposed (Suprapubic) (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C2CD4D

SOURCE GeneReport for Unigene cluster for C2CD4D Gene:

Hs.694717
genes like me logo Genes that share expression patterns with C2CD4D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2CD4D Gene

Orthologs for C2CD4D Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2CD4D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C2CD4D 30 31
  • 99.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia C2CD4D 30 31
  • 84.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia C2cd4d 30
  • 81.23 (n)
Mouse
(Mus musculus)
Mammalia C2cd4d 30 17 31
  • 81.23 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C2CD4D 31
  • 63 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C2CD4D 31
  • 45 (a)
OneToOne
Species where no ortholog for C2CD4D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C2CD4D Gene

ENSEMBL:
Gene Tree for C2CD4D (if available)
TreeFam:
Gene Tree for C2CD4D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C2CD4D: view image

Paralogs for C2CD4D Gene

genes like me logo Genes that share paralogs with C2CD4D: view

Variants for C2CD4D Gene

Additional dbSNP identifiers (rs#s) for C2CD4D Gene

Structural Variations from Database of Genomic Variants (DGV) for C2CD4D Gene

Variant ID Type Subtype PubMed ID
nsv1126220 CNV deletion 24896259
nsv516369 CNV gain 19592680

Variation tolerance for C2CD4D Gene

Gene Damage Index Score: 2.57; 44.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2CD4D Gene

Human Gene Mutation Database (HGMD)
C2CD4D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2CD4D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C2CD4D Gene

Disorders for C2CD4D Gene

Additional Disease Information for C2CD4D

No disorders were found for C2CD4D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2CD4D Gene

Publications for C2CD4D Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for C2CD4D Gene

Sources for C2CD4D Gene