Aliases for C2CD2L Gene
External Ids for C2CD2L Gene
Previous HGNC Symbols for C2CD2L Gene
Previous GeneCards Identifiers for C2CD2L Gene
GeneCards Summary for C2CD2L Gene
C2CD2L (C2CD2 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include insulin binding. An important paralog of this gene is C2CD2.
UniProtKB/Swiss-Prot Summary for C2CD2L Gene
Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843).