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Aliases for C22orf46 Gene

Aliases for C22orf46 Gene

  • Chromosome 22 Open Reading Frame 46 2 3 5
  • Uncharacterized Protein C22orf46 3
  • CTA-216E10.6 3

External Ids for C22orf46 Gene

Previous GeneCards Identifiers for C22orf46 Gene

  • GC22P040418
  • GC22P042085
  • GC22P025051

Summaries for C22orf46 Gene

GeneCards Summary for C22orf46 Gene

C22orf46 (Chromosome 22 Open Reading Frame 46) is a Protein Coding gene.

Additional gene information for C22orf46 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf46 Gene

Genomics for C22orf46 Gene

GeneHancer (GH) Regulatory Elements for C22orf46 Gene

Promoters and enhancers for C22orf46 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I041687 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.5 -543 2.6 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 C22orf46 SNU13 ENSG00000273424 RNU6-476P
GH22I041690 Promoter/Enhancer 0.7 EPDnew Ensembl 550.8 +1.5 1462 0.4 C22orf46 SNU13
GH22I040709 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -976.8 -976766 6.3 MLX FEZF1 ZNF213 ZNF416 SP3 MEF2D ZNF610 GLIS1 RCOR2 NBN L3MBTL2 EP300 PHF5A XRCC6 SLC25A17 ZC3H7B LOC100506544 SNU13 POLR3H C22orf46
GH22I041666 Enhancer 1.3 Ensembl ENCODE 10.5 -21.5 -21495 2.5 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B RN7SKP80 EP300 PHF5A RRP7BP POLDIP3 ENSG00000232754 SLC25A17 MEI1 NAGA EP300-AS1
GH22I041815 Enhancer 1 ENCODE dbSUPER 10.3 +128.6 128625 3.9 ZNF493 ZNF529 ZFP64 ZNF121 ZNF213 ZNF354C ZNF138 ZNF680 ZNF654 ZBTB11 EP300 RN7SKP80 PHF5A POLDIP3 ENSG00000232754 RPL5P34 RRP7BP L3MBTL2 XRCC6 DNAJB7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C22orf46 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C22orf46 Gene

Genomic Locations for C22orf46 Gene
chr22:41,688,939-41,698,136
(GRCh38/hg38)
Size:
9,198 bases
Orientation:
Plus strand
chr22:42,084,943-42,094,140
(GRCh37/hg19)

Genomic View for C22orf46 Gene

Genes around C22orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf46 Gene

Proteins for C22orf46 Gene

  • Protein details for C22orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9J442-CV046_HUMAN
    Recommended name:
    Uncharacterized protein C22orf46
    Protein Accession:
    C9J442

    Protein attributes for C22orf46 Gene

    Size:
    243 amino acids
    Molecular mass:
    27532 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW60455.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C22orf46 Gene

Post-translational modifications for C22orf46 Gene

  • Glycosylation at Asn30 and posLast=165165
  • Modification sites at PhosphoSitePlus

Other Protein References for C22orf46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C22orf46 Gene

Domains & Families for C22orf46 Gene

Gene Families for C22orf46 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C22orf46 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf46: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf46 Gene

Function for C22orf46 Gene

Phenotypes From GWAS Catalog for C22orf46 Gene

Phenotypes for C22orf46 Gene

GenomeRNAi human phenotypes for C22orf46:
genes like me logo Genes that share phenotypes with C22orf46: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C22orf46 Gene

Localization for C22orf46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C22orf46 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf46 gene
Compartment Confidence
extracellular 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C22orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C22orf46: view

Pathways & Interactions for C22orf46 Gene

SuperPathways for C22orf46 Gene

No Data Available

Interacting Proteins for C22orf46 Gene

Selected Interacting proteins: C9J442-CV046_HUMAN for C22orf46 Gene via IID

Gene Ontology (GO) - Biological Process for C22orf46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf46 Gene

Drugs & Compounds for C22orf46 Gene

No Compound Related Data Available

Transcripts for C22orf46 Gene

mRNA/cDNA for C22orf46 Gene

Unigene Clusters for C22orf46 Gene

Chromosome 22 open reading frame 46:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf46 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2:
SP3:

Relevant External Links for C22orf46 Gene

GeneLoc Exon Structure for
C22orf46
ECgene alternative splicing isoforms for
C22orf46

Expression for C22orf46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf46 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf46 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of C22orf46 Gene:

C22orf46

SOURCE GeneReport for Unigene cluster for C22orf46 Gene:

Hs.517653
genes like me logo Genes that share expression patterns with C22orf46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf46 Gene

Orthologs for C22orf46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf46 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C22orf46 34
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C22orf46 34
  • 62 (a)
OneToOne
Species where no ortholog for C22orf46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf46 Gene

ENSEMBL:
Gene Tree for C22orf46 (if available)
TreeFam:
Gene Tree for C22orf46 (if available)

Paralogs for C22orf46 Gene

No data available for Paralogs for C22orf46 Gene

Variants for C22orf46 Gene

Sequence variations from dbSNP and Humsavar for C22orf46 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000174801 -- 41,688,985(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000266051 -- 41,691,448(+) G/T intron_variant
rs1000303155 -- 41,688,105(+) A/G upstream_transcript_variant
rs1000401677 -- 41,693,623(+) C/A 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000834617 -- 41,693,324(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf46 Gene

Variant ID Type Subtype PubMed ID
nsv1062939 CNV gain 25217958
nsv524585 CNV loss 19592680
nsv834209 CNV loss 17160897

Variation tolerance for C22orf46 Gene

Gene Damage Index Score: 2.17; 39.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C22orf46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf46 Gene

Disorders for C22orf46 Gene

Additional Disease Information for C22orf46

No disorders were found for C22orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf46 Gene

Publications for C22orf46 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F … Gauthier JM (Genome research 2004) 3 58

Products for C22orf46 Gene

Sources for C22orf46 Gene

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