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Aliases for C22orf34 Gene

Aliases for C22orf34 Gene

  • Chromosome 22 Open Reading Frame 34 2 3 5

External Ids for C22orf34 Gene

Previous GeneCards Identifiers for C22orf34 Gene

  • GC22M048399
  • GC22M049808
  • GC22M032959

Summaries for C22orf34 Gene

GeneCards Summary for C22orf34 Gene

C22orf34 (Chromosome 22 Open Reading Frame 34) is a Protein Coding gene.

Additional gene information for C22orf34 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf34 Gene

Genomics for C22orf34 Gene

GeneHancer (GH) Regulatory Elements for C22orf34 Gene

Promoters and enhancers for C22orf34 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I049656 Promoter/Enhancer 1.4 Ensembl ENCODE 580.9 -0.6 -602 3.9 HDAC1 ATF1 TAF9B NFRKB ZBTB40 YY1 POLR2B EGR1 ZNF143 SIRT6 C22orf34 ENSG00000235111 HDAC10 CHKB ENSG00000212939 PIR60026
GH22I049669 Enhancer 0.9 Ensembl ENCODE 24.6 -12.8 -12814 2.2 PKNOX1 NFATC3 ZBTB6 SUZ12 ASH1L ZIC2 ZFHX2 GLIS2 FOS EZH2 ENSG00000235111 C22orf34 PIR60026 GC22M049688
GH22I049704 Enhancer 0.8 ENCODE 6.3 -47.2 -47186 0.1 HDAC1 PKNOX1 SMAD1 ZBTB40 TCF12 ZNF766 GATA2 EGR1 ETV6 CREM C22orf34 GC22M049688 ENSG00000226954
GH22I049712 Enhancer 0.7 FANTOM5 5.2 -54.8 -54802 0.4 TFE3 ZNF792 KLF6 HLF MIER2 REST KMT2B ZNF48 ZSCAN9 TGIF2 C22orf34 GC22M049688 ENSG00000226954
GH22I049535 Enhancer 0.4 ENCODE 7.8 +121.1 121099 2.7 SP1 CTBP2 C22orf34 ENSG00000279597 LOC105373089
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C22orf34 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C22orf34 Gene

Genomic Locations for C22orf34 Gene
243,019 bases
Minus strand

Genomic View for C22orf34 Gene

Genes around C22orf34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf34 Gene

Proteins for C22orf34 Gene

  • Protein details for C22orf34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C22orf34
    Protein Accession:
    Secondary Accessions:
    • Q147Y0
    • Q5R3D1
    • Q6ZTN8

    Protein attributes for C22orf34 Gene

    151 amino acids
    Molecular mass:
    16313 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC86548.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C22orf34 Gene


neXtProt entry for C22orf34 Gene

Post-translational modifications for C22orf34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf34 Gene

No data available for DME Specific Peptides for C22orf34 Gene

Domains & Families for C22orf34 Gene

Protein Domains for C22orf34 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf34: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf34 Gene

Function for C22orf34 Gene

Phenotypes From GWAS Catalog for C22orf34 Gene

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf34 Gene

Localization for C22orf34 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf34 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C22orf34 Gene

Pathways & Interactions for C22orf34 Gene

SuperPathways for C22orf34 Gene

No Data Available

Interacting Proteins for C22orf34 Gene

Gene Ontology (GO) - Biological Process for C22orf34 Gene


No data available for Pathways by source and SIGNOR curated interactions for C22orf34 Gene

Drugs & Compounds for C22orf34 Gene

No Compound Related Data Available

Transcripts for C22orf34 Gene

Unigene Clusters for C22orf34 Gene

Chromosome 22 open reading frame 34:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf34 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for C22orf34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C22orf34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf34 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf34 Gene

This gene is overexpressed in Spleen (x5.1) and Whole Blood (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of C22orf34 Gene:


SOURCE GeneReport for Unigene cluster for C22orf34 Gene:

genes like me logo Genes that share expression patterns with C22orf34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf34 Gene

Orthologs for C22orf34 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C22orf34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C22orf34 34
  • 94 (a)
Species where no ortholog for C22orf34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf34 Gene

Gene Tree for C22orf34 (if available)
Gene Tree for C22orf34 (if available)

Paralogs for C22orf34 Gene

No data available for Paralogs for C22orf34 Gene

Variants for C22orf34 Gene

Sequence variations from dbSNP and Humsavar for C22orf34 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000000706 -- 49,450,147(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000028660 -- 49,641,263(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000034295 -- 49,512,931(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000063557 -- 49,631,308(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000064976 -- 49,557,862(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf34 Gene

Variant ID Type Subtype PubMed ID
dgv1331e212 CNV gain 25503493
dgv1332e212 CNV loss 25503493
dgv2479n106 CNV insertion 24896259
dgv286e215 CNV deletion 23714750
dgv4590n100 CNV gain 25217958
dgv4596n100 CNV loss 25217958
dgv4597n100 CNV loss 25217958
dgv4598n100 CNV gain 25217958
dgv581n27 CNV loss 19166990
dgv752e201 CNV deletion 23290073
dgv753e201 CNV deletion 23290073
dgv754e201 CNV deletion 23290073
dgv755e201 CNV deletion 23290073
dgv8132n54 CNV gain 21841781
dgv8136n54 CNV loss 21841781
dgv848e214 CNV loss 21293372
esv1444017 CNV insertion 17803354
esv2107042 CNV deletion 18987734
esv2209836 CNV deletion 18987734
esv22186 CNV loss 19812545
esv2346218 CNV deletion 18987734
esv2426256 CNV deletion 19546169
esv25876 CNV loss 19812545
esv2657262 CNV deletion 23128226
esv2658037 CNV deletion 23128226
esv2658905 CNV deletion 23128226
esv2661643 CNV deletion 23128226
esv2664424 CNV deletion 23128226
esv2673186 CNV deletion 23128226
esv2724667 CNV deletion 23290073
esv2724668 CNV deletion 23290073
esv2724669 CNV deletion 23290073
esv2724673 CNV deletion 23290073
esv2724674 CNV deletion 23290073
esv2724675 CNV deletion 23290073
esv2724676 CNV deletion 23290073
esv2724677 CNV deletion 23290073
esv2724678 CNV deletion 23290073
esv2724679 CNV deletion 23290073
esv2724680 CNV deletion 23290073
esv2724681 CNV deletion 23290073
esv2724682 CNV deletion 23290073
esv2724684 CNV deletion 23290073
esv2724685 CNV deletion 23290073
esv2724686 CNV deletion 23290073
esv2724687 CNV deletion 23290073
esv2724688 CNV deletion 23290073
esv2724689 CNV deletion 23290073
esv2724690 CNV deletion 23290073
esv2724691 CNV deletion 23290073
esv2724692 CNV deletion 23290073
esv2758851 CNV loss 17122850
esv2763266 CNV loss 21179565
esv2763692 CNV gain 21179565
esv3417837 CNV duplication 20981092
esv3558357 CNV deletion 23714750
esv3558358 CNV deletion 23714750
esv3568482 CNV loss 25503493
esv3575498 CNV gain 25503493
esv3648030 CNV gain 21293372
esv3648037 CNV gain 21293372
esv3648053 CNV gain 21293372
esv3648054 CNV loss 21293372
esv3648055 CNV gain 21293372
esv3648056 CNV loss 21293372
esv3648057 CNV loss 21293372
esv3648058 CNV loss 21293372
esv3648059 CNV gain 21293372
esv3648060 CNV gain 21293372
esv3648061 CNV gain 21293372
esv3648063 CNV gain 21293372
esv3648065 CNV gain 21293372
esv3648066 CNV loss 21293372
esv3648067 CNV loss 21293372
esv3893494 CNV loss 25118596
esv3893495 CNV gain 25118596
esv3893497 CNV loss 25118596
esv3893498 CNV gain 25118596
esv4879 CNV loss 18987735
esv5071 CNV loss 18987735
esv999740 CNV gain 20482838
nsv1058024 CNV loss 25217958
nsv1059723 CNV gain 25217958
nsv1062352 CNV loss 25217958
nsv1065136 CNV gain 25217958
nsv1065950 CNV loss 25217958
nsv1072225 CNV deletion 25765185
nsv1076540 CNV duplication 25765185
nsv1077943 CNV duplication 25765185
nsv1121600 CNV deletion 24896259
nsv1125394 OTHER inversion 24896259
nsv1132920 CNV insertion 24896259
nsv1140167 CNV insertion 24896259
nsv1141421 CNV duplication 24896259
nsv1147217 CNV duplication 26484159
nsv1150692 CNV insertion 26484159
nsv1151689 CNV deletion 26484159
nsv1153397 CNV duplication 26484159
nsv191531 CNV deletion 16902084
nsv3664 CNV insertion 18451855
nsv459921 CNV loss 19166990
nsv459922 CNV loss 19166990
nsv471220 CNV loss 18288195
nsv510810 CNV deletion 20534489
nsv519884 CNV loss 19592680
nsv589182 CNV gain 21841781
nsv589183 CNV loss 21841781
nsv589199 CNV loss 21841781
nsv589200 CNV loss 21841781
nsv955497 CNV deletion 24416366

Variation tolerance for C22orf34 Gene

Gene Damage Index Score: 1.88; 35.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C22orf34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf34 Gene

Disorders for C22orf34 Gene

Additional Disease Information for C22orf34

No disorders were found for C22orf34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf34 Gene

Publications for C22orf34 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) Seppälä I … AtheroRemo Consortium (European heart journal 2014) 3 58
  3. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T … Xu R (Neurobiology of aging 2014) 3 58
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 58

Products for C22orf34 Gene

Sources for C22orf34 Gene

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