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Aliases for C22orf31 Gene
Aliases for C22orf31 Gene
External Ids for C22orf31 Gene
- HGNC: 26931
- Entrez Gene: 25770
- Ensembl: ENSG00000100249
- UniProtKB: O95567
Previous GeneCards Identifiers for C22orf31 Gene
- GC22M027784
- GC22M029454
- GC22M012418
Summaries for C22orf31 Gene
GeneCards Summary for C22orf31 Gene
C22orf31 (Chromosome 22 Open Reading Frame 31) is a Protein Coding gene.
Additional gene information for C22orf31 Gene
- HGNC(26931)
- Entrez Gene(25770)
- Ensembl(ENSG00000100249)
- UniProtKB(O95567)
- Open Targets Platform(ENSG00000100249)
- Search for C22orf31 at DataMed
- Search for C22orf31 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C22orf31 Gene
Genomics for C22orf31 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for C22orf31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around C22orf31 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C22orf31
- Top Transcription factor binding sites by QIAGEN in the C22orf31 gene promoter:
-
- CUTL1
- FAC1
- FOXC1
- ITF-2
- Lmo2
- Nkx6-1
- Pbx1a
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for C22orf31 Gene
Genomic Locations for C22orf31 Gene
- chr22:29,058,672-29,073,973
- (GRCh38/hg38)
- Size:
- 15,302 bases
- Orientation:
- Minus strand
- chr22:29,454,660-29,457,907
- (GRCh37/hg19)
- Size:
- 3,248 bases
- Orientation:
- Minus strand
Genomic View for C22orf31 Gene
Genes around C22orf31 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.1 by HGNC
- 22q12.1 by Entrez Gene
- 22q12.1 by Ensembl
C22orf31 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C22orf31 Gene
Proteins for C22orf31 Gene
-
Protein details for C22orf31 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95567-CV031_HUMAN
- Recommended name:
- Uncharacterized protein C22orf31
- Protein Accession:
- O95567
- A0AV97
Protein attributes for C22orf31 Gene
- Size:
- 290 amino acids
- Molecular mass:
- 32655 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for C22orf31 Gene
Other Protein References for C22orf31 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-C22ORF31 monoclonal antibody
- Novus Biologicals Antibodies for C22orf31
- Invitrogen Antibodies for C22orf31 (AFLGC-C22orf31)
- antibodies-online: Show 5 available C22orf31 Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for C22orf31
- Search Origene for MassSpec and Protein Over-expression Lysates for C22orf31
- Origene Custom Protein Services for C22orf31
-
Abcam proteins for C22orf31
No data available for DME Specific Peptides for C22orf31 Gene
Domains & Families for C22orf31 Gene
Gene Families for C22orf31 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C22orf31 Gene
Function for C22orf31 Gene
Phenotypes From GWAS Catalog for C22orf31 Gene
Phenotypes for C22orf31 Gene
- GenomeRNAi human phenotypes for C22orf31:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased gamma-H2AX phosphorylation
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased viability
- Weakly decreased NFAT1-GFP nuclear translocation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C22orf31 - Select products 50% OFF >
- * C22orf31 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for C22orf31
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C22orf31
-
Santa Cruz Biotechnology (SCBT) CRISPR for C22orf31
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C22orf31
- Browse OriGene Inhibitory RNA Products For C22orf31
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C22orf31
Clone Products
- Applied Biological Materials (abm): Clones for C22orf31 - Select products 50% OFF >
- * C22orf31 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for C22orf31
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for C22orf31
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C22orf31
Cell Line Products
-
Horizon Cell Lines for C22orf31
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf31 Gene
Localization for C22orf31 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 0 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C22orf31 Gene
Pathways & Interactions for C22orf31 Gene
Interacting Proteins for C22orf31 Gene
GPS-Prot Interaction Network for C22orf31
No data available for Pathways by source and SIGNOR curated interactions for C22orf31 Gene
Transcripts for C22orf31 Gene
mRNA/cDNA for C22orf31 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000216071 995 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C22orf31 - Select products 50% OFF >
- * C22orf31 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for C22orf31
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C22orf31
-
Santa Cruz Biotechnology (SCBT) CRISPR for C22orf31
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C22orf31
- Browse OriGene Inhibitory RNA Products For C22orf31
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C22orf31
Clone Products
- Applied Biological Materials (abm): Clones for C22orf31 - Select products 50% OFF >
- * C22orf31 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for C22orf31
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for C22orf31
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C22orf31
Relevant External Links for C22orf31 Gene
- GeneLoc Exon Structure for
- C22orf31
Expression for C22orf31 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Ectoderm (Nervous System)
mRNA differential expression in normal tissues according to GTEx for C22orf31 Gene
This gene is overexpressed in Testis (x18.3) and Brain - Putamen (basal ganglia) (x4.9).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C22orf31
SOURCE GeneReport for Unigene cluster for C22orf31 Gene:
Hs.50891Primer Products
-
OriGene qPCR primer pairs for C22orf31
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf31 Gene
Orthologs for C22orf31 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C22orf31 31 |
|
OneToOne | |
| C22H22orf31 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | C26H22orf31 30 |
|
||
| C22orf31 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | C17H22orf31 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | C22orf31 31 |
|
OneToOne |
- Species where no ortholog for C22orf31 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for C22orf31 Gene
No data available for Paralogs for C22orf31 Gene
Variants for C22orf31 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3647524 | CNV | loss | 21293372 |
| nsv1064079 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.71;
73.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C22orf31 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf31 Gene
Disorders for C22orf31 Gene
Additional Disease Information for C22orf31
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for C22orf31 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf31 Gene
Publications for C22orf31 Gene
- A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 2 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins JE … Dunham I (Genome research 2003) 3 4
- The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
ExternalLinks
Products for C22orf31 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C22orf31
- Search Origene for MassSpec and Protein Over-expression Lysates for C22orf31
- Origene Custom Protein Services for C22orf31
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C22orf31
- Browse OriGene Inhibitory RNA Products For C22orf31
- OriGene qPCR primer pairs for C22orf31
- OriGene CRISPR knockouts for C22orf31
- OriGene ORF clones in human for C22orf31
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C22orf31
- Sino Biological Human cDNA Clone for C22orf31
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for C22orf31
- Novus Biologicals proteins and lysates for C22orf31
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for C22orf31
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for C22orf31 (AFLGC-C22orf31)
- VectorBuilder Custom and pre-made DNA vectors for C22orf31 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for C22orf31 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for C22orf31 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for C22orf31 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for C22orf31
- antibodies-online: Show 5 available C22orf31 Antibodies ranked by validation data
- antibodies-online: Search results for available C22orf31 related products ranked by validation data
- antibodies-online: Search results for available C22orf31 related products ranked by validation data
- Horizon Cell Lines for C22orf31
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C22orf31
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C22orf31
- Search GeneCopoeia for miRNA 3'UTR Target clone products for C22orf31
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C22orf31
Sources for C22orf31 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB