C22orf31 Gene (Protein Coding)

Chromosome 22 Open Reading Frame 31

GC22M029058
GIFtS:
28
See more...

Aliases for C22orf31 Gene

Aliases for C22orf31 Gene

  • Chromosome 22 Open Reading Frame 31 2 3 5
  • Uncharacterized Protein C22orf31 3 4
  • BK747E2.1 2 3
  • HS747E2A 2 3
  • C22orf31 5

External Ids for C22orf31 Gene

Previous GeneCards Identifiers for C22orf31 Gene

  • GC22M027784
  • GC22M029454
  • GC22M012418

Summaries for C22orf31 Gene

GeneCards Summary for C22orf31 Gene

C22orf31 (Chromosome 22 Open Reading Frame 31) is a Protein Coding gene.

Additional gene information for C22orf31 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C22orf31 Gene

Genomics for C22orf31 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for C22orf31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C22orf31 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C22orf31

Top Transcription factor binding sites by QIAGEN in the C22orf31 gene promoter:
  • CUTL1
  • FAC1
  • FOXC1
  • ITF-2
  • Lmo2
  • Nkx6-1
  • Pbx1a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for C22orf31 Gene

Latest Assembly
chr22:29,058,672-29,073,943
(GRCh38/hg38)
Size:
15,272 bases
Orientation:
Minus strand

Previous Assembly
chr22:29,454,660-29,469,931
(GRCh37/hg19 by Entrez Gene)
Size:
15,272 bases
Orientation:
Minus strand

chr22:29,454,660-29,457,832
(GRCh37/hg19 by Ensembl)
Size:
3,173 bases
Orientation:
Minus strand

Genomic View for C22orf31 Gene

Genes around C22orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf31 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C22orf31 Gene

Proteins for C22orf31 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for C22orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95567-CV031_HUMAN
    Recommended name:
    Uncharacterized protein C22orf31
    Protein Accession:
    O95567
    Secondary Accessions:
    • A0AV97

    Protein attributes for C22orf31 Gene

    Size:
    290 amino acids
    Molecular mass:
    32655 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C22orf31 Gene

Post-translational modifications for C22orf31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C22orf31 Gene

Domains & Families for C22orf31 Gene

Gene Families for C22orf31 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C22orf31 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C22orf31: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C22orf31 Gene

Function for C22orf31 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for C22orf31 Gene

genes like me logo Genes that share phenotypes with C22orf31: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C22orf31

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf31 Gene

Localization for C22orf31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf31 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Cytosol (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C22orf31 Gene

Pathways & Interactions for C22orf31 Gene

PathCards logo

SuperPathways for C22orf31 Gene

No Data Available

Interacting Proteins for C22orf31 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000216071 O95567-CV031_HUMAN for C22orf31 Gene via STRING IID

GPS-Prot Interaction Network for C22orf31

Gene Ontology (GO) - Biological Process for C22orf31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf31 Gene

Drugs & Compounds for C22orf31 Gene

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No Compound Related Data Available

Transcripts for C22orf31 Gene

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mRNA/cDNA for C22orf31 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C22orf31

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf31 Gene

No ASD Table

Relevant External Links for C22orf31 Gene

GeneLoc Exon Structure for
C22orf31

Expression for C22orf31 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C22orf31 Gene

mRNA expression in normal human tissues for C22orf31 Gene
mRNA expression by BioGPS for C22orf31 GenemRNA expression by GTEx for C22orf31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C22orf31 Gene

This gene is overexpressed in Testis (x18.3) and Brain - Putamen (basal ganglia) (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C22orf31

SOURCE GeneReport for Unigene cluster for C22orf31 Gene:

Hs.50891
genes like me logo Genes that share expression patterns with C22orf31: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf31 Gene

Orthologs for C22orf31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf31 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia C22orf31 31
  • 100 (a)
 OneToOne
C22H22orf31 30
  • 99.77 (n)
Dog
(Canis familiaris)
 Mammalia C26H22orf31 30
  • 84.2 (n)
C22orf31 31
  • 64 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia C17H22orf31 30 31
  • 83.8 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia C22orf31 31
  • 41 (a)
 OneToOne
Species where no ortholog for C22orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C22orf31 Gene

ENSEMBL:
Gene Tree for C22orf31 (if available)
TreeFam:
Gene Tree for C22orf31 (if available)

Paralogs for C22orf31 Gene

No data available for Paralogs for C22orf31 Gene

Variants for C22orf31 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C22orf31 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
983322 Uncertain Significance: Intellectual disability 29,060,720(-) C/A
NM_015370.1:c.127G>T 		MISSENSE
983323 Uncertain Significance: Intellectual disability 29,060,794(-) C/T
NM_015370.1:c.53G>A 		MISSENSE
rs714136 - p.Thr210Arg
rs9625679 - p.Cys46Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C22orf31 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C22orf31 Gene

Variant ID Type Subtype PubMed ID
esv3647524 CNV loss 21293372
nsv1064079 CNV gain 25217958

Variation tolerance for C22orf31 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C22orf31 Gene

Human Gene Mutation Database (HGMD)
C22orf31
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf31

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf31 Gene

Disorders for C22orf31 Gene

Additional Disease Information for C22orf31

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for C22orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf31 Gene

Publications for C22orf31 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins JE … Dunham I (Genome research 2003) 3 4
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4

ExternalLinks

View latest publications for C22orf31 gene in Mastermind

Products for C22orf31 Gene

Sources for C22orf31 Gene