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Aliases for C22orf31 Gene

Aliases for C22orf31 Gene

  • Chromosome 22 Open Reading Frame 31 2 3 5
  • Uncharacterized Protein C22orf31 3
  • BK747E2.1 3
  • HS747E2A 3

External Ids for C22orf31 Gene

Previous GeneCards Identifiers for C22orf31 Gene

  • GC22M027784
  • GC22M029454
  • GC22M012418

Summaries for C22orf31 Gene

GeneCards Summary for C22orf31 Gene

C22orf31 (Chromosome 22 Open Reading Frame 31) is a Protein Coding gene.

Additional gene information for C22orf31 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf31 Gene

Genomics for C22orf31 Gene

GeneHancer (GH) Regulatory Elements for C22orf31 Gene

Promoters and enhancers for C22orf31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I029070 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.8 821 4.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 GLIS2 ZNF207 KREMEN1 C22orf31 ENSG00000226772 CCDC117 EMID1 XBP1
GH22I029028 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 54.1 +42.7 42736 4.8 FOXA2 MLX ARID4B YY1 ZNF766 FOS SP3 SP5 ZHX2 REST ZNRF3-AS1 C22orf31 CCDC117 KREMEN1 ZNRF3 ENSG00000226471 XBP1 ENSG00000226772 RNU6-810P ASCC2
GH22I029201 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -131.8 -131760 8.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A YBX1 IRF4 TCF12 GLIS2 ZNF207 EMID1 LOC101929638 EWSR1 TTC28 KREMEN1 C22orf31 CHEK2 GC22P029193
GH22I028882 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 +190.1 190115 2.9 HDGF SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 ZNRF3 C22orf31 CCDC117 CHEK2 HSCB GC22P028904 LOC646408
GH22I028678 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 +393.9 393915 2.5 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF213 FOS KLF13 TTC28 CHEK2 TTC28-AS1 CCDC117 C22orf31 PIR35028
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C22orf31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C22orf31 gene promoter:

Genomic Locations for C22orf31 Gene

Genomic Locations for C22orf31 Gene
chr22:29,058,672-29,073,966
(GRCh38/hg38)
Size:
15,295 bases
Orientation:
Minus strand
chr22:29,454,660-29,457,907
(GRCh37/hg19)

Genomic View for C22orf31 Gene

Genes around C22orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf31 Gene

Proteins for C22orf31 Gene

  • Protein details for C22orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95567-CV031_HUMAN
    Recommended name:
    Uncharacterized protein C22orf31
    Protein Accession:
    O95567
    Secondary Accessions:
    • A0AV97

    Protein attributes for C22orf31 Gene

    Size:
    290 amino acids
    Molecular mass:
    32655 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C22orf31 Gene

Post-translational modifications for C22orf31 Gene

No Post-translational modifications

Other Protein References for C22orf31 Gene

No data available for DME Specific Peptides for C22orf31 Gene

Domains & Families for C22orf31 Gene

Gene Families for C22orf31 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C22orf31 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf31: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf31 Gene

Function for C22orf31 Gene

Phenotypes From GWAS Catalog for C22orf31 Gene

genes like me logo Genes that share phenotypes with C22orf31: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf31 Gene

Localization for C22orf31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf31 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C22orf31 Gene

Pathways & Interactions for C22orf31 Gene

SuperPathways for C22orf31 Gene

No Data Available

Interacting Proteins for C22orf31 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000216071%0d%0a9606.ENSP00000257867%0d%0a9606.ENSP00000362649%0d%0a
Selected Interacting proteins: O95567-CV031_HUMAN ENSP00000216071 for C22orf31 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C22orf31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf31 Gene

Drugs & Compounds for C22orf31 Gene

No Compound Related Data Available

Transcripts for C22orf31 Gene

mRNA/cDNA for C22orf31 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C22orf31 Gene

Chromosome 22 open reading frame 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf31 Gene

No ASD Table

Relevant External Links for C22orf31 Gene

GeneLoc Exon Structure for
C22orf31
ECgene alternative splicing isoforms for
C22orf31

Expression for C22orf31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C22orf31 Gene

This gene is overexpressed in Testis (x18.3) and Brain - Putamen (basal ganglia) (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of C22orf31 Gene:

C22orf31

SOURCE GeneReport for Unigene cluster for C22orf31 Gene:

Hs.50891
genes like me logo Genes that share expression patterns with C22orf31: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf31 Gene

Orthologs for C22orf31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22orf31 34
  • 100 (a)
OneToOne
C22H22orf31 33
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia C26H22orf31 33
  • 84.2 (n)
C22orf31 34
  • 64 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C17H22orf31 33 34
  • 83.8 (n)
oppossum
(Monodelphis domestica)
Mammalia C22orf31 34
  • 41 (a)
OneToOne
Species where no ortholog for C22orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf31 Gene

ENSEMBL:
Gene Tree for C22orf31 (if available)
TreeFam:
Gene Tree for C22orf31 (if available)

Paralogs for C22orf31 Gene

No data available for Paralogs for C22orf31 Gene

Variants for C22orf31 Gene

Sequence variations from dbSNP and Humsavar for C22orf31 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000069822 -- 29,064,907(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000934495 -- 29,064,930(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000983241 -- 29,064,645(-) C/A genic_upstream_transcript_variant, intron_variant
rs1001102414 -- 29,063,296(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001239381 -- 29,072,819(-) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf31 Gene

Variant ID Type Subtype PubMed ID
nsv1064079 CNV gain 25217958
esv3647524 CNV loss 21293372

Variation tolerance for C22orf31 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C22orf31 Gene

Human Gene Mutation Database (HGMD)
C22orf31
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf31 Gene

Disorders for C22orf31 Gene

Additional Disease Information for C22orf31

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C22orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf31 Gene

Publications for C22orf31 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins JE … Dunham I (Genome research 2003) 3 4 58
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58

Products for C22orf31 Gene

Sources for C22orf31 Gene

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