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Aliases for C22orf24 Gene

Aliases for C22orf24 Gene

  • Chromosome 22 Open Reading Frame 24 2 3 5
  • Uncharacterized Protein C22orf24 3
  • HSN44A4A 3

External Ids for C22orf24 Gene

Previous GeneCards Identifiers for C22orf24 Gene

  • GC22M030655
  • GC22U900262
  • GC22M032329
  • GC22M015286

Summaries for C22orf24 Gene

GeneCards Summary for C22orf24 Gene

C22orf24 (Chromosome 22 Open Reading Frame 24) is a Protein Coding gene.

Additional gene information for C22orf24 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf24 Gene

Genomics for C22orf24 Gene

GeneHancer (GH) Regulatory Elements for C22orf24 Gene

Promoters and enhancers for C22orf24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I031942 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.3 335 5.1 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 GLIS2 ARID2 YWHAH C22orf24 RNU6-201P DEPDC5 PRR14L SELENOM SFI1 PLA2G3
GH22I031895 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 10.3 +49.9 49895 1 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ATF7 NCOA1 MBD2 SMARCA4 DEPDC5 RNU6-201P YWHAH C22orf24 PISD SFI1 PRR14L RFPL2 ENSG00000227813
GH22I031917 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.9 +27.7 27717 1.6 HDGF BACH1 JUNB EBF1 DPF2 BATF ZIC2 IRF4 BCL11A IKZF1 YWHAH C22orf24 RNU6-201P DEPDC5 PRR14L SLC5A1 ENSG00000227813
GH22I031665 Enhancer 1.1 Ensembl ENCODE 10.9 +279.8 279817 0.6 ARID4B ZNF2 ZNF121 ZNF143 KLF7 SP3 SP5 REST KAT8 NFIL3 MORC2 EIF4ENIF1 TUG1 PRR14L DEPDC5 C22orf24 YWHAH RNU6-201P SFI1 PISD
GH22I031911 Enhancer 0.9 ENCODE 12.2 +33.5 33549 1.1 ZFP64 ARID4B ETS1 TCF12 SP5 KAT8 NFIL3 MIER3 ETV4 KDM1A C22orf24 YWHAH RNU6-201P DEPDC5 SLC5A1 ENSG00000227813
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C22orf24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C22orf24 gene promoter:

Genomic Locations for C22orf24 Gene

Genomic Locations for C22orf24 Gene
chr22:31,925,316-31,945,518
(GRCh38/hg38)
Size:
20,203 bases
Orientation:
Minus strand
chr22:32,329,507-32,341,504
(GRCh37/hg19)

Genomic View for C22orf24 Gene

Genes around C22orf24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf24 Gene

Proteins for C22orf24 Gene

  • Protein details for C22orf24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y442-CV024_HUMAN
    Recommended name:
    Uncharacterized protein C22orf24
    Protein Accession:
    Q9Y442
    Secondary Accessions:
    • B2RCT4
    • Q5K3R1

    Protein attributes for C22orf24 Gene

    Size:
    160 amino acids
    Molecular mass:
    17735 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C22orf24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C22orf24 Gene

Post-translational modifications for C22orf24 Gene

No Post-translational modifications

Other Protein References for C22orf24 Gene

No data available for DME Specific Peptides for C22orf24 Gene

Domains & Families for C22orf24 Gene

Protein Domains for C22orf24 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C22orf24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf24: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C22orf24 Gene

Function for C22orf24 Gene

Phenotypes From GWAS Catalog for C22orf24 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C22orf24 Gene

Localization for C22orf24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C22orf24 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf24 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for C22orf24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C22orf24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C22orf24 Gene

Pathways & Interactions for C22orf24 Gene

SuperPathways for C22orf24 Gene

No Data Available

Interacting Proteins for C22orf24 Gene

Selected Interacting proteins: Q9Y442-CV024_HUMAN for C22orf24 Gene via IID

Gene Ontology (GO) - Biological Process for C22orf24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf24 Gene

Drugs & Compounds for C22orf24 Gene

No Compound Related Data Available

Transcripts for C22orf24 Gene

mRNA/cDNA for C22orf24 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C22orf24 Gene

Chromosome 22 open reading frame 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf24 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for C22orf24 Gene

GeneLoc Exon Structure for
C22orf24
ECgene alternative splicing isoforms for
C22orf24

Expression for C22orf24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf24 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf24 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Cortex (x4.7), Brain - Hippocampus (x4.6), Brain - Nucleus accumbens (basal ganglia) (x4.6), and Brain - Frontal Cortex (BA9) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of C22orf24 Gene:

C22orf24

SOURCE GeneReport for Unigene cluster for C22orf24 Gene:

Hs.627602

Evidence on tissue expression from TISSUES for C22orf24 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with C22orf24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf24 Gene

Orthologs for C22orf24 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C22orf24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22orf24 34
  • 68 (a)
OneToOne
Species where no ortholog for C22orf24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf24 Gene

ENSEMBL:
Gene Tree for C22orf24 (if available)
TreeFam:
Gene Tree for C22orf24 (if available)

Paralogs for C22orf24 Gene

No data available for Paralogs for C22orf24 Gene

Variants for C22orf24 Gene

Sequence variations from dbSNP and Humsavar for C22orf24 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000483049 -- 31,942,004(-) GGG/GG genic_upstream_transcript_variant, intron_variant
rs1000525777 -- 31,943,833(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000693389 -- 31,946,173(-) G/C upstream_transcript_variant
rs1001230307 -- 31,938,500(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001469236 -- 31,942,596(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf24 Gene

Variant ID Type Subtype PubMed ID
esv3568359 CNV loss 25503493
nsv1072209 CNV deletion 25765185
nsv1110864 OTHER inversion 24896259
nsv508731 CNV insertion 20534489

Variation tolerance for C22orf24 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C22orf24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf24 Gene

Disorders for C22orf24 Gene

Additional Disease Information for C22orf24

No disorders were found for C22orf24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf24 Gene

Publications for C22orf24 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for C22orf24 Gene

Sources for C22orf24 Gene

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