Aliases for C22orf15 Gene

Aliases for C22orf15 Gene

  • Chromosome 22 Open Reading Frame 15 2 3 5
  • Uncharacterized Protein C22orf15 3 4
  • Protein N27C7-3 3 4
  • N27C7-3 2 3
  • C22orf15 5
  • FLJ36561 2

External Ids for C22orf15 Gene

Previous GeneCards Identifiers for C22orf15 Gene

  • GC22P022430
  • GC22P022431
  • GC22P022435
  • GC22P024105
  • GC22P007093
  • GC22P023918

Summaries for C22orf15 Gene

GeneCards Summary for C22orf15 Gene

C22orf15 (Chromosome 22 Open Reading Frame 15) is a Protein Coding gene. Diseases associated with C22orf15 include Tetralogy Of Fallot.

Additional gene information for C22orf15 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C22orf15 Gene

Genomics for C22orf15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C22orf15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C22orf15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C22orf15

Top Transcription factor binding sites by QIAGEN in the C22orf15 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • HEN1
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-4a

Genomic Locations for C22orf15 Gene

Genomic Locations for C22orf15 Gene
chr22:23,762,523-23,765,863
(GRCh38/hg38)
Size:
3,341 bases
Orientation:
Plus strand
chr22:24,105,208-24,108,050
(GRCh37/hg19)
Size:
2,843 bases
Orientation:
Plus strand

Genomic View for C22orf15 Gene

Genes around C22orf15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf15 Gene

Proteins for C22orf15 Gene

  • Protein details for C22orf15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYQ4-CV015_HUMAN
    Recommended name:
    Uncharacterized protein C22orf15
    Protein Accession:
    Q8WYQ4
    Secondary Accessions:
    • Q6ICJ7

    Protein attributes for C22orf15 Gene

    Size:
    148 amino acids
    Molecular mass:
    16487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C22orf15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C22orf15 Gene

Post-translational modifications for C22orf15 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C22orf15 Gene

Domains & Families for C22orf15 Gene

Gene Families for C22orf15 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C22orf15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C22orf15 Gene

GenScript: Design optimal peptide antigens:
  • Protein N27C7-3 (CV015_HUMAN)
  • Chromosome 22 open reading frame 15, isoform CRA_c (Q14D93_HUMAN)
genes like me logo Genes that share domains with C22orf15: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C22orf15 Gene

Function for C22orf15 Gene

Phenotypes From GWAS Catalog for C22orf15 Gene

genes like me logo Genes that share phenotypes with C22orf15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C22orf15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf15 Gene

Localization for C22orf15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf15 gene
Compartment Confidence
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C22orf15 Gene

Pathways & Interactions for C22orf15 Gene

PathCards logo

SuperPathways for C22orf15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C22orf15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf15 Gene

Drugs & Compounds for C22orf15 Gene

No Compound Related Data Available

Transcripts for C22orf15 Gene

mRNA/cDNA for C22orf15 Gene

5 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C22orf15

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - - - -
SP3:

Relevant External Links for C22orf15 Gene

GeneLoc Exon Structure for
C22orf15

Expression for C22orf15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C22orf15 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf15 Gene

This gene is overexpressed in Testis (x8.1), Fallopian Tube (x5.1), Lung (x4.6), and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for C22orf15 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C22orf15 Gene



Protein tissue co-expression partners for C22orf15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C22orf15

SOURCE GeneReport for Unigene cluster for C22orf15 Gene:

Hs.116254
genes like me logo Genes that share expression patterns with C22orf15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf15 Gene

Orthologs for C22orf15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C22H22orf15 30
  • 99.1 (n)
C22orf15 31
  • 59 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C26H22orf15 30
  • 77.08 (n)
C22orf15 31
  • 66 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C17H22orf15 30
  • 76.26 (n)
C22orf15 31
  • 52 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm867 30 17 31
  • 69.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1564162 30
  • 68.81 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia C22orf15 31
  • 49 (a)
OneToOne
Species where no ortholog for C22orf15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C22orf15 Gene

ENSEMBL:
Gene Tree for C22orf15 (if available)
TreeFam:
Gene Tree for C22orf15 (if available)

Paralogs for C22orf15 Gene

No data available for Paralogs for C22orf15 Gene

Variants for C22orf15 Gene

Additional dbSNP identifiers (rs#s) for C22orf15 Gene

Structural Variations from Database of Genomic Variants (DGV) for C22orf15 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for C22orf15 Gene

Gene Damage Index Score: 2.47; 43.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C22orf15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C22orf15 Gene

Disorders for C22orf15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C22orf15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tetralogy of fallot
  • tof
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C22orf15

genes like me logo Genes that share disorders with C22orf15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C22orf15 Gene

Publications for C22orf15 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for C22orf15 Gene

Sources for C22orf15 Gene