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Aliases for C20orf85 Gene

Aliases for C20orf85 Gene

  • Chromosome 20 Open Reading Frame 85 2 3 5
  • Low In Lung Cancer 1 2 3
  • Uncharacterized Protein C20orf85 3
  • BA196N14.1 3
  • LLC1 3

External Ids for C20orf85 Gene

Previous GeneCards Identifiers for C20orf85 Gene

  • GC20P056454
  • GC20P057364
  • GC20P057411
  • GC20P056159
  • GC20P056726
  • GC20P053508

Summaries for C20orf85 Gene

GeneCards Summary for C20orf85 Gene

C20orf85 (Chromosome 20 Open Reading Frame 85) is a Protein Coding gene. Diseases associated with C20orf85 include Lung Cancer.

Additional gene information for C20orf85 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C20orf85 Gene

Genomics for C20orf85 Gene

GeneHancer (GH) Regulatory Elements for C20orf85 Gene

Promoters and enhancers for C20orf85 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I058150 Promoter/Enhancer 1 EPDnew ENCODE 550.8 0.0 -34 0.1 MXI1 RFX1 MAX SIN3A BMI1 C20orf85 GC20P058098
GH20I058129 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -19.4 -19436 3.7 SOX13 CTCF FOXA2 SAP130 PAX8 YBX1 THRB RARA TEAD3 SCRT2 C20orf85 GC20P058098
GH20I058110 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.3 -38.2 -38241 3.3 PKNOX1 ATF1 FOS ATF7 IKZF2 CREM SMARCA5 ELF1 ZNF592 ZNF217 GC20P058098 C20orf85
GH20I058179 Enhancer 1 Ensembl ENCODE 0.3 +28.8 28770 1.1 RB1 NFIB SIN3A ZNF2 ZBTB7B ZNF48 RAD21 GLIS2 EGR1 ZNF143 LOC105372694 PCK1 ANKRD60 CTCFL C20orf85
GH20I058135 Enhancer 0.7 Ensembl dbSUPER 0.4 -15.4 -15403 0.2 SOX5 SOX13 RNF2 PRDM10 SMAD4 ZNF7 ANKRD60 C20orf85 GC20P058098
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C20orf85 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C20orf85 gene promoter:

Genomic Locations for C20orf85 Gene

Genomic Locations for C20orf85 Gene
10,247 bases
Plus strand

Genomic View for C20orf85 Gene

Genes around C20orf85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C20orf85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C20orf85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C20orf85 Gene

Proteins for C20orf85 Gene

  • Protein details for C20orf85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C20orf85
    Protein Accession:

    Protein attributes for C20orf85 Gene

    137 amino acids
    Molecular mass:
    15719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C20orf85 Gene

Post-translational modifications for C20orf85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C20orf85 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C20orf85 Gene

Domains & Families for C20orf85 Gene

Gene Families for C20orf85 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C20orf85 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C20orf85: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C20orf85 Gene

Function for C20orf85 Gene

Phenotypes From GWAS Catalog for C20orf85 Gene

genes like me logo Genes that share phenotypes with C20orf85: view

miRNA for C20orf85 Gene

miRTarBase miRNAs that target C20orf85

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C20orf85 Gene

Localization for C20orf85 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C20orf85 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C20orf85 Gene

Pathways & Interactions for C20orf85 Gene

SuperPathways for C20orf85 Gene

No Data Available

Interacting Proteins for C20orf85 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000360210 Q9H1P6-CT085_HUMAN for C20orf85 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C20orf85 Gene


No data available for Pathways by source and SIGNOR curated interactions for C20orf85 Gene

Drugs & Compounds for C20orf85 Gene

No Compound Related Data Available

Transcripts for C20orf85 Gene

mRNA/cDNA for C20orf85 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C20orf85 Gene

Chromosome 20 open reading frame 85:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C20orf85 Gene

No ASD Table

Relevant External Links for C20orf85 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C20orf85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C20orf85 Gene

mRNA differential expression in normal tissues according to GTEx for C20orf85 Gene

This gene is overexpressed in Testis (x23.2), Fallopian Tube (x12.6), Cervix - Endocervix (x9.4), and Lung (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of C20orf85 Gene:


SOURCE GeneReport for Unigene cluster for C20orf85 Gene:


Evidence on tissue expression from TISSUES for C20orf85 Gene

  • Lung(2.5)
genes like me logo Genes that share expression patterns with C20orf85: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C20orf85 Gene

Orthologs for C20orf85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C20orf85 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C20H20orf85 33
  • 99.03 (n)
C20orf85 34
  • 99 (a)
(Bos Taurus)
Mammalia C13H20ORF85 34
  • 86 (a)
C13H20orf85 33
  • 85.48 (n)
(Canis familiaris)
Mammalia C24H20orf85 33
  • 83.94 (n)
C20orf85 34
  • 83 (a)
(Rattus norvegicus)
Mammalia LOC689618 33
  • 75.8 (n)
(Mus musculus)
Mammalia 1700021F07Rik 33 16 34
  • 75.74 (n)
(Ornithorhynchus anatinus)
Mammalia C20orf85 34
  • 56 (a)
(Monodelphis domestica)
Mammalia C20orf85 34
  • 55 (a)
(Gallus gallus)
Aves C20H20ORF85 33
  • 60.61 (n)
C20orf85 34
  • 38 (a)
(Anolis carolinensis)
Reptilia C20orf85 34
  • 60 (a)
Species where no ortholog for C20orf85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C20orf85 Gene

Gene Tree for C20orf85 (if available)
Gene Tree for C20orf85 (if available)

Paralogs for C20orf85 Gene

No data available for Paralogs for C20orf85 Gene

Variants for C20orf85 Gene

Sequence variations from dbSNP and Humsavar for C20orf85 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000266879 -- 58,149,428(+) C/T upstream_transcript_variant
rs1000298080 -- 58,149,719(+) T/C upstream_transcript_variant
rs1000815480 -- 58,159,766(+) C/A intron_variant
rs1000866497 -- 58,159,441(+) G/A intron_variant
rs1001103212 -- 58,149,355(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C20orf85 Gene

Variant ID Type Subtype PubMed ID
nsv1058640 CNV gain 25217958
nsv1061416 CNV gain 25217958

Variation tolerance for C20orf85 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C20orf85 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C20orf85 Gene

Disorders for C20orf85 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C20orf85 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C20orf85

genes like me logo Genes that share disorders with C20orf85: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C20orf85 Gene

Publications for C20orf85 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. Immunohistochemical localization of LLC1 in human tissues and its limited expression in non-small cell lung cancer. (PMID: 25786037) Chandra V … Hong KM (Histology and histopathology 2015) 3 58
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  5. Inactivation of LLC1 gene in nonsmall cell lung cancer. (PMID: 17304513) Hong KM … Jen J (International journal of cancer 2007) 3 58

Products for C20orf85 Gene

Sources for C20orf85 Gene

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