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Aliases for C20orf27 Gene

Aliases for C20orf27 Gene

  • Chromosome 20 Open Reading Frame 27 2 3 5
  • Hypothetical Protein LOC54976 2
  • UPF0687 Protein C20orf27 3

External Ids for C20orf27 Gene

Previous GeneCards Identifiers for C20orf27 Gene

  • GC20M003722
  • GC20M003729
  • GC20M003682

Summaries for C20orf27 Gene

GeneCards Summary for C20orf27 Gene

C20orf27 (Chromosome 20 Open Reading Frame 27) is a Protein Coding gene.

Gene Wiki entry for C20orf27 Gene

Additional gene information for C20orf27 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C20orf27 Gene

Genomics for C20orf27 Gene

GeneHancer (GH) Regulatory Elements for C20orf27 Gene

Promoters and enhancers for C20orf27 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J003763 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 673 +1.7 1671 6.7 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 C20orf27 CDC25B GC20M003756
GH20J003780 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.5 -15.8 -15782 6.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 YY1 SLC30A9 ZNF766 ZNF143 SPEF1 CDC25B VPS16 ENSG00000229539 UBOX5 PCED1A UBOX5-AS1 MAVS C20orf27 CENPB
GH20J003739 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.6 +28.7 28689 0.6 SOX5 GATAD2A USF1 TFE3 SAP130 MNT RARA KAT8 RAD51 MXD3 C20orf27 SIGLEC1 CDC25B CENPB SPEF1 PANK2 ENSG00000229539 HSPA12B PIR58376
GH20J003744 Enhancer 1 Ensembl ENCODE 12.1 +23.1 23082 1.7 HDAC1 ATF1 ARNT KLF17 KLF14 KLF7 FOS ATF7 CREM EGR2 C20orf27 SPEF1 CDC25B CENPB AP5S1 ENSG00000229539 PANK2 PIR58376 HSPA12B
GH20J003838 Enhancer 0.9 Ensembl ENCODE 11.1 -70.8 -70750 1.5 HDAC1 TEAD4 TAL1 TCF12 CTBP1 GATA2 NCOR1 ZNF366 POLR2A ZFP91 CDC25B HSPA12B CENPB ENSG00000229539 PANK2 SPEF1 C20orf27 MAVS AP5S1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C20orf27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C20orf27 gene promoter:
  • GR
  • GR-alpha
  • Nkx2-5
  • CUTL1
  • NF-kappaB1
  • Lmo2

Genomic Locations for C20orf27 Gene

Genomic Locations for C20orf27 Gene
14,890 bases
Minus strand
14,880 bases
Minus strand

Genomic View for C20orf27 Gene

Genes around C20orf27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C20orf27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C20orf27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C20orf27 Gene

Proteins for C20orf27 Gene

  • Protein details for C20orf27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0687 protein C20orf27
    Protein Accession:
    Secondary Accessions:
    • A8K4J0
    • D3DVX8
    • Q5JX81
    • Q9NWX3

    Protein attributes for C20orf27 Gene

    174 amino acids
    Molecular mass:
    19291 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C20orf27 Gene


neXtProt entry for C20orf27 Gene

Post-translational modifications for C20orf27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C20orf27 Gene

No data available for DME Specific Peptides for C20orf27 Gene

Domains & Families for C20orf27 Gene

Gene Families for C20orf27 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C20orf27 Gene


Suggested Antigen Peptide Sequences for C20orf27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0687 family.
  • Belongs to the UPF0687 family.
genes like me logo Genes that share domains with C20orf27: view

Function for C20orf27 Gene

Phenotypes From GWAS Catalog for C20orf27 Gene

Gene Ontology (GO) - Molecular Function for C20orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with C20orf27: view
genes like me logo Genes that share phenotypes with C20orf27: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C20orf27 Gene

Localization for C20orf27 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C20orf27 gene
Compartment Confidence
mitochondrion 3
extracellular 2
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C20orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C20orf27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C20orf27 Gene

Pathways & Interactions for C20orf27 Gene

SuperPathways for C20orf27 Gene

No Data Available

Interacting Proteins for C20orf27 Gene

Gene Ontology (GO) - Biological Process for C20orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C20orf27: view

No data available for Pathways by source and SIGNOR curated interactions for C20orf27 Gene

Drugs & Compounds for C20orf27 Gene

No Compound Related Data Available

Transcripts for C20orf27 Gene

Unigene Clusters for C20orf27 Gene

Chromosome 20 open reading frame 27:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C20orf27 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: - - - - - - -
SP9: - -

Relevant External Links for C20orf27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C20orf27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C20orf27 Gene

mRNA differential expression in normal tissues according to GTEx for C20orf27 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Putamen (basal ganglia) (x4.3), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for C20orf27 Gene

This gene is overexpressed in Cardia (11.6) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C20orf27 Gene

Protein tissue co-expression partners for C20orf27 Gene

NURSA nuclear receptor signaling pathways regulating expression of C20orf27 Gene:


SOURCE GeneReport for Unigene cluster for C20orf27 Gene:


Evidence on tissue expression from TISSUES for C20orf27 Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with C20orf27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C20orf27 Gene

Orthologs for C20orf27 Gene

This gene was present in the common ancestor of animals.

Orthologs for C20orf27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C20H20orf27 33
  • 99.33 (n)
C20orf27 34
  • 99 (a)
(Bos Taurus)
Mammalia C20orf27 34
  • 92 (a)
C13H20orf27 33
  • 87.98 (n)
(Canis familiaris)
Mammalia C24H20orf27 33
  • 90.5 (n)
(Rattus norvegicus)
Mammalia RGD1311739 33
  • 87.02 (n)
(Mus musculus)
Mammalia 1700037H04Rik 16 34 33
  • 86.82 (n)
(Ornithorhynchus anatinus)
Mammalia C20orf27 34
  • 56 (a)
(Gallus gallus)
Aves LOC100858801 33
  • 69.93 (n)
C20orf27 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c20orf27 33
  • 67.83 (n)
Str.268 33
(Danio rerio)
Actinopterygii LOC560941 33
  • 62.96 (n)
C20orf27 (1 of 2) 34
  • 56 (a)
C20orf27 (2 of 2) 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6983 34
  • 28 (a)
Species where no ortholog for C20orf27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C20orf27 Gene

Gene Tree for C20orf27 (if available)
Gene Tree for C20orf27 (if available)

Paralogs for C20orf27 Gene Pseudogenes for C20orf27 Gene

genes like me logo Genes that share paralogs with C20orf27: view

No data available for Paralogs for C20orf27 Gene

Variants for C20orf27 Gene

Sequence variations from dbSNP and Humsavar for C20orf27 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000211955 -- 3,764,666(-) C/T intron_variant
rs1000267308 -- 3,757,914(-) G/A intron_variant
rs1000416166 -- 3,760,083(-) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000752640 -- 3,758,747(-) C/T intron_variant
rs1000812809 -- 3,753,114(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C20orf27 Gene

Variant ID Type Subtype PubMed ID
esv2722120 CNV deletion 23290073
esv3645048 CNV loss 21293372
nsv585284 CNV loss 21841781
nsv585285 CNV loss 21841781
nsv585286 CNV loss 21841781
nsv828673 CNV gain 20364138
nsv833899 CNV loss 17160897

Variation tolerance for C20orf27 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C20orf27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C20orf27 Gene

Disorders for C20orf27 Gene

Additional Disease Information for C20orf27

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C20orf27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C20orf27 Gene

Publications for C20orf27 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  5. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 58

Products for C20orf27 Gene

Sources for C20orf27 Gene

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