Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C20orf197 Gene

Aliases for C20orf197 Gene

  • Chromosome 20 Open Reading Frame 197 2 3 5
  • Uncharacterized Protein C20orf197 3

External Ids for C20orf197 Gene

Previous GeneCards Identifiers for C20orf197 Gene

  • GC20P058065
  • GC20P058630
  • GC20P055418

Summaries for C20orf197 Gene

GeneCards Summary for C20orf197 Gene

C20orf197 (Chromosome 20 Open Reading Frame 197) is a Protein Coding gene.

Additional gene information for C20orf197 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C20orf197 Gene

Genomics for C20orf197 Gene

GeneHancer (GH) Regulatory Elements for C20orf197 Gene

Promoters and enhancers for C20orf197 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J060054 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 669.3 +1.0 1023 4.9 YBX1 FEZF1 GLIS2 ELK1 ZNF143 REST ZNF518A ZNF592 GLIS1 WT1 C20orf197 PPP1R3D FAM217B SYCP2 ENSG00000276093
GH20J060085 Enhancer 0.6 dbSUPER 23.1 +30.3 30347 1.4 CTCF GATA3 PKNOX1 RFX1 CREB1 DPF2 FOS CUX1 MIR646HG LOC729296 PIR38189 GC20M060087 C20orf197 ENSG00000276093
GH20J060087 Promoter/Enhancer 1 Ensembl ENCODE 12.6 +31.7 31733 0.5 CTBP1 MTA1 SUZ12 NFIB CREB1 BMI1 ZFX MIR646HG LOC729296 PIR38189 GC20M060087 C20orf197
GH20J060045 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -9.4 -9364 1.5 OSR2 POLR2A GLIS1 MAX CREB1 OVOL3 REST MYC SPI1 C20orf197 PPP1R3D FAM217B PHACTR3 CDH26
GH20J059987 Enhancer 1 ENCODE dbSUPER 11.5 -67.8 -67782 1.4 PKNOX1 NFIB NFRKB NEUROD1 SIN3A NFXL1 YBX1 BMI1 ZBTB7B ZBTB40 C20orf197 CDH26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C20orf197 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C20orf197 gene promoter:
  • LHX3b
  • Lhx3a
  • Max1
  • AML1a
  • Olf-1
  • HNF-1A
  • HNF-1
  • MyoD
  • Tal-1beta
  • ITF-2

Genomic Locations for C20orf197 Gene

Genomic Locations for C20orf197 Gene
chr20:60,055,925-60,072,953
(GRCh38/hg38)
Size:
17,029 bases
Orientation:
Plus strand
chr20:58,630,980-58,648,008
(GRCh37/hg19)
Size:
17,029 bases
Orientation:
Plus strand

Genomic View for C20orf197 Gene

Genes around C20orf197 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C20orf197 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C20orf197 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C20orf197 Gene

Proteins for C20orf197 Gene

  • Protein details for C20orf197 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N268-CT197_HUMAN
    Recommended name:
    Uncharacterized protein C20orf197
    Protein Accession:
    Q8N268
    Secondary Accessions:
    • Q08EQ0

    Protein attributes for C20orf197 Gene

    Size:
    126 amino acids
    Molecular mass:
    14459 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C20orf197 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C20orf197 Gene

Post-translational modifications for C20orf197 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C20orf197 Gene

Domains & Families for C20orf197 Gene

Protein Domains for C20orf197 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C20orf197: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C20orf197 Gene

Function for C20orf197 Gene

Phenotypes for C20orf197 Gene

genes like me logo Genes that share phenotypes with C20orf197: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C20orf197 Gene

Localization for C20orf197 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C20orf197 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C20orf197 Gene

Pathways & Interactions for C20orf197 Gene

SuperPathways for C20orf197 Gene

No Data Available

Interacting Proteins for C20orf197 Gene

Selected Interacting proteins: Q8N268-CT197_HUMAN for C20orf197 Gene via IID

Symbol External ID(s) Details
ESR1

Gene Ontology (GO) - Biological Process for C20orf197 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C20orf197 Gene

Drugs & Compounds for C20orf197 Gene

No Compound Related Data Available

Transcripts for C20orf197 Gene

mRNA/cDNA for C20orf197 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(1) RNA Central transcripts :

Unigene Clusters for C20orf197 Gene

Chromosome 20 open reading frame 197:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C20orf197 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for C20orf197 Gene

GeneLoc Exon Structure for
C20orf197
ECgene alternative splicing isoforms for
C20orf197

Expression for C20orf197 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C20orf197 Gene

mRNA differential expression in normal tissues according to GTEx for C20orf197 Gene

This gene is overexpressed in Whole Blood (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of C20orf197 Gene:

C20orf197

SOURCE GeneReport for Unigene cluster for C20orf197 Gene:

Hs.335319
genes like me logo Genes that share expression patterns with C20orf197: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C20orf197 Gene

Orthologs for C20orf197 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C20orf197 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C20H20orf197 33
  • 99.47 (n)
C20orf197 34
  • 99 (a)
OneToOne
Species where no ortholog for C20orf197 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C20orf197 Gene

ENSEMBL:
Gene Tree for C20orf197 (if available)
TreeFam:
Gene Tree for C20orf197 (if available)

Paralogs for C20orf197 Gene

No data available for Paralogs for C20orf197 Gene

Variants for C20orf197 Gene

Sequence variations from dbSNP and Humsavar for C20orf197 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000045513 -- 60,063,246(+) A/C 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000131280 -- 60,060,042(+) C/A 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000227594 -- 60,060,229(+) C/T 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000246202 -- 60,066,399(+) C/G 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000389700 -- 60,048,627(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C20orf197 Gene

Variant ID Type Subtype PubMed ID
esv2559283 CNV deletion 19546169
esv2631555 CNV insertion 19546169
esv3305313 CNV mobile element insertion 20981092
esv3440988 CNV insertion 20981092
nsv819951 CNV gain 19587683

Variation tolerance for C20orf197 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C20orf197 Gene

Human Gene Mutation Database (HGMD)
C20orf197
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C20orf197

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C20orf197 Gene

Disorders for C20orf197 Gene

Additional Disease Information for C20orf197

No disorders were found for C20orf197 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C20orf197 Gene

Publications for C20orf197 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58

Products for C20orf197 Gene

Sources for C20orf197 Gene

Content
Loading form....