Aliases for C20orf173 Gene

Aliases for C20orf173 Gene

  • Chromosome 20 Open Reading Frame 173 2 3 5
  • Uncharacterized Protein C20orf173 3 4
  • DJ477O4.4 2 3
  • C20orf173 5

External Ids for C20orf173 Gene

Previous GeneCards Identifiers for C20orf173 Gene

  • GC20M033873
  • GC20M033833
  • GC20M034783
  • GC20M034830
  • GC20M033578
  • GC20M034109
  • GC20M030886

Summaries for C20orf173 Gene

GeneCards Summary for C20orf173 Gene

C20orf173 (Chromosome 20 Open Reading Frame 173) is a Protein Coding gene. An important paralog of this gene is ST3GAL1.

Additional gene information for C20orf173 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C20orf173 Gene

Genomics for C20orf173 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C20orf173 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C20orf173 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the C20orf173 gene promoter:
  • AML1a
  • CUTL1
  • HNF-1
  • HNF-1A
  • Ik-1
  • LCR-F1
  • Pax-6
  • XBP-1

Genomic Locations for C20orf173 Gene

Latest Assembly
chr20:35,520,741-35,529,846
(GRCh38/hg38)
Size:
9,106 bases
Orientation:
Minus strand

Previous Assembly
chr20:34,108,569-34,117,481
(GRCh37/hg19 by Entrez Gene)
Size:
8,913 bases
Orientation:
Minus strand

chr20:34,111,014-34,117,481
(GRCh37/hg19 by Ensembl)
Size:
6,468 bases
Orientation:
Minus strand

Genomic View for C20orf173 Gene

Genes around C20orf173 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C20orf173 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C20orf173 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C20orf173 Gene

Proteins for C20orf173 Gene

  • Protein details for C20orf173 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LM9-CT173_HUMAN
    Recommended name:
    Uncharacterized protein C20orf173
    Protein Accession:
    Q96LM9
    Secondary Accessions:
    • A6PVJ1
    • Q2M293
    • Q5JWS4
    • Q9H449

    Protein attributes for C20orf173 Gene

    Size:
    149 amino acids
    Molecular mass:
    16552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C20orf173 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C20orf173 Gene

Post-translational modifications for C20orf173 Gene

No Post-translational modifications

Other Protein References for C20orf173 Gene

No data available for DME Specific Peptides for C20orf173 Gene

Domains & Families for C20orf173 Gene

Gene Families for C20orf173 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C20orf173 Gene

InterPro:
genes like me logo Genes that share domains with C20orf173: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C20orf173 Gene

Function for C20orf173 Gene

Phenotypes From GWAS Catalog for C20orf173 Gene

Gene Ontology (GO) - Molecular Function for C20orf173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with C20orf173: view
genes like me logo Genes that share phenotypes with C20orf173: view

miRNA for C20orf173 Gene

miRTarBase miRNAs that target C20orf173

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C20orf173

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C20orf173 Gene

Localization for C20orf173 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C20orf173 gene
Compartment Confidence
extracellular 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C20orf173 Gene

Pathways & Interactions for C20orf173 Gene

PathCards logo

SuperPathways for C20orf173 Gene

No Data Available

Interacting Proteins for C20orf173 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q96LM9-CT173_HUMAN ENSP00000403566 for C20orf173 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for C20orf173 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C20orf173 Gene

Drugs & Compounds for C20orf173 Gene

No Compound Related Data Available

Transcripts for C20orf173 Gene

mRNA/cDNA for C20orf173 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C20orf173

Alternative Splicing Database (ASD) splice patterns (SP) for C20orf173 Gene

No ASD Table

Relevant External Links for C20orf173 Gene

GeneLoc Exon Structure for
C20orf173

Expression for C20orf173 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C20orf173 Gene

mRNA differential expression in normal tissues according to GTEx for C20orf173 Gene

This gene is overexpressed in Testis (x52.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C20orf173

SOURCE GeneReport for Unigene cluster for C20orf173 Gene:

Hs.158680
genes like me logo Genes that share expression patterns with C20orf173: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C20orf173 Gene

Orthologs for C20orf173 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C20orf173 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC745624 29
  • 98.51 (n)
C20orf173 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC610148 29
  • 76.47 (n)
Mouse
(Mus musculus)
Mammalia 6430550D23Rik 29 16 30
  • 67.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102550306 29
  • 66.28 (n)
Cow
(Bos Taurus)
Mammalia C20orf173 30
  • 30 (a)
OneToOne
Species where no ortholog for C20orf173 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C20orf173 Gene

ENSEMBL:
Gene Tree for C20orf173 (if available)
TreeFam:
Gene Tree for C20orf173 (if available)
Alliance of Genome Resources:
Additional Orthologs for C20orf173

Paralogs for C20orf173 Gene

genes like me logo Genes that share paralogs with C20orf173: view

Variants for C20orf173 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C20orf173 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs7261862 -- p.Lys141Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C20orf173 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C20orf173 Gene

Variant ID Type Subtype PubMed ID
nsv1062839 CNV loss 25217958
nsv3364 CNV insertion 18451855

Variation tolerance for C20orf173 Gene

Gene Damage Index Score: 4.13; 61.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C20orf173 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C20orf173
Leiden Open Variation Database (LOVD)
C20orf173

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C20orf173 Gene

Disorders for C20orf173 Gene

Additional Disease Information for C20orf173

No disorders were found for C20orf173 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C20orf173 Gene

Publications for C20orf173 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for C20orf173 Gene

Sources for C20orf173 Gene