Aliases for C20orf141 Gene

Aliases for C20orf141 Gene

  • Chromosome 20 Open Reading Frame 141 2 3 5
  • Uncharacterized Protein C20orf141 3 4
  • DJ860F19.4 3

External Ids for C20orf141 Gene

Previous GeneCards Identifiers for C20orf141 Gene

  • GC20P002783
  • GC20P002743
  • GC20P002790
  • GC20P002803
  • GC20P002749
  • GC20P002808
  • GC20P002924
  • GC20P002926
  • GC20P002936
  • GC20P002819
  • GC20P002832
  • GC20P002847
  • GC20P002859
  • GC20P002873
  • GC20P002886
  • GC20P002899
  • GC20P002912

Summaries for C20orf141 Gene

GeneCards Summary for C20orf141 Gene

C20orf141 (Chromosome 20 Open Reading Frame 141) is a Protein Coding gene. An important paralog of this gene is ENSG00000241690.

Additional gene information for C20orf141 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C20orf141 Gene

Genomics for C20orf141 Gene

GeneHancer (GH) Regulatory Elements for C20orf141 Gene

Promoters and enhancers for C20orf141 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J002813 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 500.7 +0.0 14 2.4 ZSCAN5C FOS ZIC2 NCOR1 NFIC ZBTB17 ZNF184 FOSL2 USF1 TAL1 C20orf141 ENSG00000241690 TMEM239 CPXM1 VPS16
GH20J002816 Promoter 0.4 EPDnew 500.7 +1.4 1358 0.1 PRDM1 C20orf141 ENSG00000241690 TMEM239 CPXM1 piR-50308-366
GH20J002870 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.8 +58.1 58137 5.8 HNRNPK EP300 CTCF ZSCAN5C TCF12 NRF1 POLR2G SP1 NCOR1 GTF2E2 PTPRA VPS16 SNRPB ZNF343 PCED1A MAVS EBF4 C20orf141 ENSG00000241690 TMEM239
GH20J002750 Promoter/Enhancer 1.3 Ensembl ENCODE 11.4 -63.1 -63119 2.7 CTCF USF1 POLR2G ZNF639 ZBTB10 FOXA1 ZBTB26 REST KLF7 ZBTB25 HSALNG0128208 VPS16 ZNF343 SNRPB PTPRA PCED1A C20orf141 ENSG00000241690 TMEM239 EBF4
GH20J002738 Enhancer 1.3 VISTA Ensembl ENCODE 10.9 -74.0 -73986 5.2 CTCF GABPA REST TGIF2 ZBTB7A TRIM22 SMC3 NFIC ZBTB17 RAD21 EBF4 VPS16 PTPRA PCED1A ENSG00000241690 TMEM239 C20orf141 ENSG00000228293 IDH3B SNORD56
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C20orf141 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C20orf141

Top Transcription factor binding sites by QIAGEN in the C20orf141 gene promoter:
  • C/EBPalpha
  • Egr-2
  • ER-alpha
  • GATA-1
  • Ik-3
  • MyoD
  • Pax-4a
  • RORalpha1
  • SEF-1 (1)
  • XBP-1

Genomic Locations for C20orf141 Gene

Genomic Locations for C20orf141 Gene
chr20:2,814,987-2,815,833
(GRCh38/hg38)
Size:
847 bases
Orientation:
Plus strand
chr20:2,795,633-2,796,479
(GRCh37/hg19)
Size:
847 bases
Orientation:
Plus strand

Genomic View for C20orf141 Gene

Genes around C20orf141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C20orf141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C20orf141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C20orf141 Gene

Proteins for C20orf141 Gene

  • Protein details for C20orf141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUB4-CT141_HUMAN
    Recommended name:
    Uncharacterized protein C20orf141
    Protein Accession:
    Q9NUB4

    Protein attributes for C20orf141 Gene

    Size:
    165 amino acids
    Molecular mass:
    17394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C20orf141 Gene

Post-translational modifications for C20orf141 Gene

No Post-translational modifications

Other Protein References for C20orf141 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C20orf141 Gene

Domains & Families for C20orf141 Gene

Gene Families for C20orf141 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C20orf141 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C20orf141 Gene

GenScript: Design optimal peptide antigens:
  • C20orf141 protein (Q8WW34_HUMAN)
genes like me logo Genes that share domains with C20orf141: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C20orf141 Gene

Function for C20orf141 Gene

Phenotypes From GWAS Catalog for C20orf141 Gene

genes like me logo Genes that share phenotypes with C20orf141: view

Animal Model Products

CRISPR Products

miRNA for C20orf141 Gene

miRTarBase miRNAs that target C20orf141

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C20orf141 Gene

Localization for C20orf141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C20orf141 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for C20orf141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C20orf141: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for C20orf141 Gene

Pathways & Interactions for C20orf141 Gene

PathCards logo

SuperPathways for C20orf141 Gene

No Data Available

Interacting Proteins for C20orf141 Gene

Selected Interacting proteins: Q9NUB4-CT141_HUMAN for C20orf141 Gene via IID

Symbol External ID(s) Details
LMNA
ZDHHC17
;

Gene Ontology (GO) - Biological Process for C20orf141 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C20orf141 Gene

Drugs & Compounds for C20orf141 Gene

No Compound Related Data Available

Transcripts for C20orf141 Gene

mRNA/cDNA for C20orf141 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C20orf141 Gene

No ASD Table

Relevant External Links for C20orf141 Gene

GeneLoc Exon Structure for
C20orf141

Expression for C20orf141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C20orf141 Gene

mRNA differential expression in normal tissues according to GTEx for C20orf141 Gene

This gene is overexpressed in Testis (x51.1).

Protein differential expression in normal tissues from HIPED for C20orf141 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C20orf141 Gene



Protein tissue co-expression partners for C20orf141 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C20orf141

SOURCE GeneReport for Unigene cluster for C20orf141 Gene:

Hs.352187

Evidence on tissue expression from TISSUES for C20orf141 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with C20orf141: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C20orf141 Gene

Orthologs for C20orf141 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C20orf141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C20H20orf141 30
  • 98.59 (n)
C20orf141 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C24H20orf141 30
  • 82.21 (n)
C20orf141 31
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C13H20orf141 30
  • 80.66 (n)
C20orf141 31
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700020A23Rik 17 31 30
  • 75.66 (n)
rat
(Rattus norvegicus)
Mammalia LOC100365450 30
  • 75.66 (n)
Species where no ortholog for C20orf141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C20orf141 Gene

ENSEMBL:
Gene Tree for C20orf141 (if available)
TreeFam:
Gene Tree for C20orf141 (if available)

Paralogs for C20orf141 Gene

Paralogs for C20orf141 Gene

(1) SIMAP similar genes for C20orf141 Gene using alignment to 1 proteins:

  • CT141_HUMAN
genes like me logo Genes that share paralogs with C20orf141: view

Variants for C20orf141 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C20orf141 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs386352285 Uncertain Significance: not provided 2,815,542(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for C20orf141 Gene

Structural Variations from Database of Genomic Variants (DGV) for C20orf141 Gene

Variant ID Type Subtype PubMed ID
esv2762056 CNV gain 21179565
nsv1057464 CNV gain 25217958
nsv510780 CNV deletion 20534489
nsv518364 CNV loss 19592680
nsv522009 CNV gain 19592680
nsv833895 CNV loss 17160897

Variation tolerance for C20orf141 Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C20orf141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C20orf141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C20orf141 Gene

Disorders for C20orf141 Gene

Additional Disease Information for C20orf141

No disorders were found for C20orf141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C20orf141 Gene

Publications for C20orf141 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 54
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 54
  4. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 54
  5. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PMID: 23218918) Sprooten E … McIntosh AM (Psychiatry research 2013) 3 54

Products for C20orf141 Gene

Sources for C20orf141 Gene