Aliases for C1orf74 Gene

Aliases for C1orf74 Gene

  • Chromosome 1 Open Reading Frame 74 2 3 5
  • Up-Regulated In Lung Cancer 4 2 3
  • UPF0739 Protein C1orf74 3 4
  • URLC4 3

External Ids for C1orf74 Gene

Previous GeneCards Identifiers for C1orf74 Gene

  • GC01M206345
  • GC01M208022
  • GC01M209955
  • GC01M180630

Summaries for C1orf74 Gene

GeneCards Summary for C1orf74 Gene

C1orf74 (Chromosome 1 Open Reading Frame 74) is a Protein Coding gene. Diseases associated with C1orf74 include Cortisone Reductase Deficiency.

Additional gene information for C1orf74 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf74 Gene

Genomics for C1orf74 Gene

GeneHancer (GH) Regulatory Elements for C1orf74 Gene

Promoters and enhancers for C1orf74 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J209782 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.1 -1088 6 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 JUND C1orf74 TRAF3IP3 IRF6 SYT14 lnc-C1orf74-1
GH01J209822 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -41.6 -41603 7.3 FOXK2 ZBTB40 CTCF SIN3A NRF1 TCF12 MYC POLR2G USF1 PHB2 UTP25 lnc-IRF6-2 IRF6 SYT14 C1orf74 HSD11B1-AS1 TRAF3IP3 RF00017-462 HSALNG0010228
GH01J209814 Enhancer 1.4 VISTA FANTOM5 ENCODE dbSUPER 11.5 -31.5 -31538 3.9 POLR2A TCF7 FOS STAT3 BCL6 ETV4 SOX5 ZNF687 SP1 EZH2 HSALNG0010228 IRF6 C1orf74 HSD11B1-AS1 SYT14 LAMB3
GH01J209829 Enhancer 0.6 Ensembl dbSUPER 10.8 -47.0 -47042 1.2 FOS ZNF513 JUND POLR2A RBFOX2 IRF6 SYT14 C1orf74 RF00017-462 UTP25 HSALNG0010231
GH01J209754 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.5 +27.5 27483 5.1 SP1 ZIC2 RCOR1 TRIM22 POLR2A BCL11A CBFB GABPA NBN SPI1 TRAF3IP3 HSD11B1-AS1 G0S2 IRF6 C1orf74 lnc-TRAF3IP3-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf74 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf74

Top Transcription factor binding sites by QIAGEN in the C1orf74 gene promoter:
  • AhR
  • Arnt
  • ATF
  • CREB
  • MIF-1
  • p53
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)

Genomic Locations for C1orf74 Gene

Genomic Locations for C1orf74 Gene
chr1:209,779,208-209,784,559
(GRCh38/hg38)
Size:
5,352 bases
Orientation:
Minus strand
chr1:209,955,661-209,957,904
(GRCh37/hg19)
Size:
2,244 bases
Orientation:
Minus strand

Genomic View for C1orf74 Gene

Genes around C1orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf74 Gene

Proteins for C1orf74 Gene

  • Protein details for C1orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LT6-CA074_HUMAN
    Recommended name:
    UPF0739 protein C1orf74
    Protein Accession:
    Q96LT6

    Protein attributes for C1orf74 Gene

    Size:
    269 amino acids
    Molecular mass:
    29561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf74 Gene

Post-translational modifications for C1orf74 Gene

No Post-translational modifications

Other Protein References for C1orf74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf74 Gene

Domains & Families for C1orf74 Gene

Gene Families for C1orf74 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf74 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf74 Gene

GenScript: Design optimal peptide antigens:
  • UPF0739 protein C1orf74 (CA074_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LT6

UniProtKB/Swiss-Prot:

CA074_HUMAN :
  • Belongs to the UPF0739 family.
Family:
  • Belongs to the UPF0739 family.
genes like me logo Genes that share domains with C1orf74: view

Function for C1orf74 Gene

Phenotypes From GWAS Catalog for C1orf74 Gene

genes like me logo Genes that share phenotypes with C1orf74: view

Animal Model Products

CRISPR Products

miRNA for C1orf74 Gene

miRTarBase miRNAs that target C1orf74

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf74 Gene

Localization for C1orf74 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf74 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf74 Gene

Pathways & Interactions for C1orf74 Gene

PathCards logo

SuperPathways for C1orf74 Gene

No Data Available

Interacting Proteins for C1orf74 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000294811 Q96LT6-CA074_HUMAN for C1orf74 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for C1orf74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf74 Gene

Drugs & Compounds for C1orf74 Gene

No Compound Related Data Available

Transcripts for C1orf74 Gene

mRNA/cDNA for C1orf74 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf74 Gene

No ASD Table

Relevant External Links for C1orf74 Gene

GeneLoc Exon Structure for
C1orf74

Expression for C1orf74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf74 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf74

SOURCE GeneReport for Unigene cluster for C1orf74 Gene:

Hs.497642
genes like me logo Genes that share expression patterns with C1orf74: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf74 Gene

Orthologs for C1orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf74 30
  • 99.5 (n)
C1orf74 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf74 30
  • 87.73 (n)
C1orf74 31
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C16H1orf74 30
  • 85.8 (n)
C1orf74 31
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A130010J15Rik 17 31 30
  • 82 (n)
rat
(Rattus norvegicus)
Mammalia LOC100125367 30
  • 81.5 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf74 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF74 30
  • 56.24 (n)
C1orf74 31
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf74 31
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf74 30
  • 49.81 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:112163 30
  • 50.13 (n)
C6H1orf74 31
  • 37 (a)
OneToOne
Species where no ortholog for C1orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf74 Gene

ENSEMBL:
Gene Tree for C1orf74 (if available)
TreeFam:
Gene Tree for C1orf74 (if available)

Paralogs for C1orf74 Gene

No data available for Paralogs for C1orf74 Gene

Variants for C1orf74 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf74 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs7550857 - p.Leu146Phe

Additional dbSNP identifiers (rs#s) for C1orf74 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1orf74 Gene

Variant ID Type Subtype PubMed ID
nsv1006632 CNV gain 25217958
nsv4343 CNV deletion 18451855

Variation tolerance for C1orf74 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf74 Gene

Disorders for C1orf74 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1orf74 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cortisone reductase deficiency
  • cortrd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C1orf74

genes like me logo Genes that share disorders with C1orf74: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf74 Gene

Publications for C1orf74 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  5. Notch 1 promotes cisplatin-resistant gastric cancer formation by upregulating lncRNA AK022798 expression. (PMID: 25763542) Hang Q … Li Y (Anti-cancer drugs 2015) 3 54

Products for C1orf74 Gene

Sources for C1orf74 Gene