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Aliases for C1orf74 Gene

Aliases for C1orf74 Gene

  • Chromosome 1 Open Reading Frame 74 2 3 5
  • Up-Regulated In Lung Cancer 4 2 3
  • UPF0739 Protein C1orf74 3
  • URLC4 3

External Ids for C1orf74 Gene

Previous GeneCards Identifiers for C1orf74 Gene

  • GC01M206345
  • GC01M208022
  • GC01M209955
  • GC01M180630

Summaries for C1orf74 Gene

GeneCards Summary for C1orf74 Gene

C1orf74 (Chromosome 1 Open Reading Frame 74) is a Protein Coding gene.

Additional gene information for C1orf74 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf74 Gene

Genomics for C1orf74 Gene

GeneHancer (GH) Regulatory Elements for C1orf74 Gene

Promoters and enhancers for C1orf74 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I209782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.1 -1088 6 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B C1orf74 TRAF3IP3 IRF6 SYT14
GH01I209822 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.5 -41.2 -41203 6.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 DIEXF IRF6 SYT14 C1orf74 LOC101930114 TRAF3IP3
GH01I209814 Enhancer 1.5 VISTA FANTOM5 ENCODE dbSUPER 11.5 -31.5 -31538 3.9 CTCF SOX5 GATAD2A ZNF687 ZSCAN4 EBF1 MNT GABPA ETV4 TCF7 IRF6 C1orf74 LOC101930114 SYT14 LAMB3 DIEXF
GH01I209754 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.4 +27.5 27483 5.1 PKNOX1 BACH1 EBF1 YBX1 ZIC2 POLR2A SCRT2 ATF7 ETV6 IKZF2 TRAF3IP3 LOC101930114 G0S2 IRF6 C1orf74
GH01I209761 Enhancer 0.6 FANTOM5 dbSUPER 12.1 +23.4 23386 0.1 SPI1 C1orf74 LAMB3 G0S2 LOC101930114 TRAF3IP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf74 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf74 gene promoter:

Genomic Locations for C1orf74 Gene

Genomic Locations for C1orf74 Gene
chr1:209,779,208-209,784,559
(GRCh38/hg38)
Size:
5,352 bases
Orientation:
Minus strand
chr1:209,955,661-209,957,904
(GRCh37/hg19)

Genomic View for C1orf74 Gene

Genes around C1orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf74 Gene

Proteins for C1orf74 Gene

  • Protein details for C1orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LT6-CA074_HUMAN
    Recommended name:
    UPF0739 protein C1orf74
    Protein Accession:
    Q96LT6

    Protein attributes for C1orf74 Gene

    Size:
    269 amino acids
    Molecular mass:
    29561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf74 Gene

Post-translational modifications for C1orf74 Gene

No Post-translational modifications

Other Protein References for C1orf74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf74 Gene

Domains & Families for C1orf74 Gene

Gene Families for C1orf74 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf74 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LT6

UniProtKB/Swiss-Prot:

CA074_HUMAN :
  • Belongs to the UPF0739 family.
Family:
  • Belongs to the UPF0739 family.
genes like me logo Genes that share domains with C1orf74: view

Function for C1orf74 Gene

Phenotypes From GWAS Catalog for C1orf74 Gene

genes like me logo Genes that share phenotypes with C1orf74: view

miRNA for C1orf74 Gene

miRTarBase miRNAs that target C1orf74

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf74 Gene

Localization for C1orf74 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf74 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf74 Gene

Pathways & Interactions for C1orf74 Gene

SuperPathways for C1orf74 Gene

No Data Available

Interacting Proteins for C1orf74 Gene

Selected Interacting proteins: Q96LT6-CA074_HUMAN for C1orf74 Gene via IID

Symbol External ID(s) Details
TP63

Gene Ontology (GO) - Biological Process for C1orf74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf74 Gene

Drugs & Compounds for C1orf74 Gene

No Compound Related Data Available

Transcripts for C1orf74 Gene

mRNA/cDNA for C1orf74 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf74 Gene

Chromosome 1 open reading frame 74:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf74 Gene

No ASD Table

Relevant External Links for C1orf74 Gene

GeneLoc Exon Structure for
C1orf74
ECgene alternative splicing isoforms for
C1orf74

Expression for C1orf74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf74 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf74 Gene:

C1orf74

SOURCE GeneReport for Unigene cluster for C1orf74 Gene:

Hs.497642
genes like me logo Genes that share expression patterns with C1orf74: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf74 Gene

Orthologs for C1orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf74 33
  • 99.5 (n)
C1orf74 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf74 33
  • 87.73 (n)
C1orf74 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C16H1orf74 33
  • 85.8 (n)
C1orf74 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A130010J15Rik 33 16 34
  • 82 (n)
rat
(Rattus norvegicus)
Mammalia LOC100125367 33
  • 81.5 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf74 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF74 33
  • 56.24 (n)
C1orf74 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf74 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf74 33
  • 49.81 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:112163 33
  • 50.13 (n)
C6H1orf74 34
  • 37 (a)
OneToOne
Species where no ortholog for C1orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf74 Gene

ENSEMBL:
Gene Tree for C1orf74 (if available)
TreeFam:
Gene Tree for C1orf74 (if available)

Paralogs for C1orf74 Gene

No data available for Paralogs for C1orf74 Gene

Variants for C1orf74 Gene

Sequence variations from dbSNP and Humsavar for C1orf74 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1044516 benign, Popliteal pterygium syndrome, Cleft Lip +/- Cleft Palate, Autosomal Dominant, Van der Woude syndrome 209,786,269(-) G/T upstream_transcript_variant
rs112896538 likely-benign, Popliteal pterygium syndrome, Cleft Lip +/- Cleft Palate, Autosomal Dominant, Van der Woude syndrome 209,786,006(-) C/T upstream_transcript_variant
rs144945364 likely-benign, Van der Woude syndrome, Popliteal pterygium syndrome, Cleft Lip +/- Cleft Palate, Autosomal Dominant 209,786,026(-) T/TT upstream_transcript_variant
rs1856161 benign, Popliteal pterygium syndrome, Cleft Lip +/- Cleft Palate, Autosomal Dominant, Van der Woude syndrome 209,785,823(-) C/G/T upstream_transcript_variant
rs188593210 likely-benign, Cleft Lip +/- Cleft Palate, Autosomal Dominant, Van der Woude syndrome, Popliteal pterygium syndrome 209,785,948(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf74 Gene

Variant ID Type Subtype PubMed ID
nsv4343 CNV deletion 18451855
nsv1006632 CNV gain 25217958

Variation tolerance for C1orf74 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf74 Gene

Disorders for C1orf74 Gene

Additional Disease Information for C1orf74

No disorders were found for C1orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf74 Gene

Publications for C1orf74 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Notch 1 promotes cisplatin-resistant gastric cancer formation by upregulating lncRNA AK022798 expression. (PMID: 25763542) Hang Q … Li Y (Anti-cancer drugs 2015) 3 58

Products for C1orf74 Gene

Sources for C1orf74 Gene

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