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Aliases for C1orf61 Gene

Aliases for C1orf61 Gene

  • Chromosome 1 Open Reading Frame 61 2 3 5
  • Contingent Replication Of CDNA 4 3 4
  • CROC4 3 4
  • Transcriptional Activator Of The C Fos Promoter 2
  • Transcriptional Activator Of The C-Fos Promoter 3
  • Contingent Replication Of CDNA-4 2
  • Protein CROC-4 3

External Ids for C1orf61 Gene

Previous GeneCards Identifiers for C1orf61 Gene

  • GC01M153188
  • GC01M154640
  • GC01M156374
  • GC01M127734

Summaries for C1orf61 Gene

GeneCards Summary for C1orf61 Gene

C1orf61 (Chromosome 1 Open Reading Frame 61) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C1orf61 Gene

  • May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.

Additional gene information for C1orf61 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf61 Gene

Genomics for C1orf61 Gene

GeneHancer (GH) Regulatory Elements for C1orf61 Gene

Promoters and enhancers for C1orf61 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I156419 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 550.4 +12.4 12398 4.3 ATF1 SIN3A ZNF2 TCF12 ZNF121 GLIS2 FOS ATF7 RUNX3 SP3 MIR9-1 C1orf61 KHDC4 GON4L RRNAD1 ENSG00000271267 MSTO1 MSTO2P CCT3 PRCC
GH01I156429 Promoter/Enhancer 1 EPDnew dbSUPER 550.8 +4.9 4879 0.1 SUZ12 IKZF1 CREB1 ATF2 C1orf61 GC01M156428
GH01I156436 Enhancer 0.6 Ensembl dbSUPER 550.8 -1.4 -1376 0.2 RING1 SUZ12 EZH2 C1orf61 MSTO2P MSTO1 KHDC4 ASH1L-AS1 ARHGEF11 ENSG00000271267 ENSG00000236947
GH01I156432 Enhancer 0.4 dbSUPER 550.8 +1.5 1478 1 USF1 MAX EZH2 C1orf61 CCT3 TSACC RHBG ENSG00000223356 GC01M156428
GH01I156435 Enhancer 0.4 dbSUPER 550.8 -0.9 -866 0.2 SUZ12 EZH2 C1orf61 ENSG00000236947
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf61 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf61 gene promoter:

Genomic Locations for C1orf61 Gene

Genomic Locations for C1orf61 Gene
chr1:156,404,250-156,434,325
(GRCh38/hg38)
Size:
30,076 bases
Orientation:
Minus strand
chr1:156,374,042-156,400,493
(GRCh37/hg19)

Genomic View for C1orf61 Gene

Genes around C1orf61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf61 Gene

Proteins for C1orf61 Gene

  • Protein details for C1orf61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13536-CROC4_HUMAN
    Recommended name:
    Protein CROC-4
    Protein Accession:
    Q13536
    Secondary Accessions:
    • B1ALL5
    • B1ALL8

    Protein attributes for C1orf61 Gene

    Size:
    156 amino acids
    Molecular mass:
    17231 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C1orf61 Gene

Post-translational modifications for C1orf61 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C1orf61 Gene

Domains & Families for C1orf61 Gene

Gene Families for C1orf61 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf61 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf61: view

No data available for UniProtKB/Swiss-Prot for C1orf61 Gene

Function for C1orf61 Gene

Molecular function for C1orf61 Gene

UniProtKB/Swiss-Prot Function:
May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.

Phenotypes From GWAS Catalog for C1orf61 Gene

Gene Ontology (GO) - Molecular Function for C1orf61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C1orf61: view
genes like me logo Genes that share phenotypes with C1orf61: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf61 Gene

Localization for C1orf61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf61 Gene

Nucleus. Note=Associates within the nuclear transcriptional apparatus during proliferation and differentiation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf61 gene
Compartment Confidence
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for C1orf61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10995546
genes like me logo Genes that share ontologies with C1orf61: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1orf61 Gene

Pathways & Interactions for C1orf61 Gene

SuperPathways for C1orf61 Gene

No Data Available

Interacting Proteins for C1orf61 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357226%0d%0a9606.ENSP00000419782%0d%0a
Selected Interacting proteins: ENSP00000357226 Q13536-CROC4_HUMAN for C1orf61 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C1orf61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 10995546
genes like me logo Genes that share ontologies with C1orf61: view

No data available for Pathways by source and SIGNOR curated interactions for C1orf61 Gene

Drugs & Compounds for C1orf61 Gene

No Compound Related Data Available

Transcripts for C1orf61 Gene

Unigene Clusters for C1orf61 Gene

Chromosome 1 open reading frame 61:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf61 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - -
SP17: -
SP18: - - - - -
SP19: - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - -
SP21: - - - - -
SP22: - - - - - - - - - - - - - - - - -

ExUns: 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g · 16h
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - -
SP8:
SP9: - - - - - -
SP10:
SP11: - - - - - -
SP12: -
SP13: - - - - - -
SP14: - - - - - -
SP15:
SP16: -
SP17:
SP18: - - - - - -
SP19: - - - - - -
SP20: - - - - - -
SP21: - - - - - -
SP22: - - - - - -

Relevant External Links for C1orf61 Gene

GeneLoc Exon Structure for
C1orf61
ECgene alternative splicing isoforms for
C1orf61

Expression for C1orf61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf61 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x5.8), Brain - Amygdala (x5.8), Brain - Putamen (basal ganglia) (x5.8), Brain - Substantia nigra (x4.6), and Brain - Hippocampus (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf61 Gene



Protein tissue co-expression partners for C1orf61 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf61 Gene:

C1orf61

SOURCE GeneReport for Unigene cluster for C1orf61 Gene:

Hs.380027

mRNA Expression by UniProt/SwissProt for C1orf61 Gene:

Q13536-CROC4_HUMAN
Tissue specificity: Expressed throughout the brain in the thalamus, subthalamic nucleus, corpus callosum, hippocampus, substantia nigra, caudate nucleus, and amygdala.

Evidence on tissue expression from TISSUES for C1orf61 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with C1orf61: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf61 Gene

Orthologs for C1orf61 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C1orf61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf61 34
  • 99 (a)
OneToOne
C1H1orf61 33
  • 89.38 (n)
Species where no ortholog for C1orf61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf61 Gene

ENSEMBL:
Gene Tree for C1orf61 (if available)
TreeFam:
Gene Tree for C1orf61 (if available)

Paralogs for C1orf61 Gene

No data available for Paralogs for C1orf61 Gene

Variants for C1orf61 Gene

Sequence variations from dbSNP and Humsavar for C1orf61 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000060698 -- 156,455,238(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000088694 -- 156,448,760(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000092665 -- 156,430,151(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000121548 -- 156,448,490(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000139919 -- 156,405,482(-) C/A genic_downstream_transcript_variant, intron_variant

Variation tolerance for C1orf61 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C1orf61 Gene

Disorders for C1orf61 Gene

Additional Disease Information for C1orf61

No disorders were found for C1orf61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf61 Gene

Publications for C1orf61 Gene

  1. CROC-4: a novel brain specific transcriptional activator of c-fos expressed from proliferation through to maturation of multiple neuronal cell types. (PMID: 10995546) Jeffrey PL … Lin SL (Molecular and cellular neurosciences 2000) 2 3 4 58
  2. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. (PMID: 23012322) Hu HM … Li W (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013) 2 3 58
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58
  4. Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. (PMID: 19922823) Reppe S … Gautvik KM (Bone 2010) 3 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58

Products for C1orf61 Gene

Sources for C1orf61 Gene

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