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Aliases for C1orf54 Gene

Aliases for C1orf54 Gene

  • Chromosome 1 Open Reading Frame 54 2 3 5
  • Uncharacterized Protein C1orf54 3

External Ids for C1orf54 Gene

Previous GeneCards Identifiers for C1orf54 Gene

  • GC01P147059
  • GC01P148507
  • GC01P150240
  • GC01P121623

Summaries for C1orf54 Gene

GeneCards Summary for C1orf54 Gene

C1orf54 (Chromosome 1 Open Reading Frame 54) is a Protein Coding gene.

Additional gene information for C1orf54 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf54 Gene

Genomics for C1orf54 Gene

GeneHancer (GH) Regulatory Elements for C1orf54 Gene

Promoters and enhancers for C1orf54 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J150266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.3 315 3.3 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 POLR2B C1orf54 APH1A ARNT PIP5K1A PRUNE1 SETDB1 MRPS21 C1orf56 SEMA6C
GH01J150271 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 661.5 +4.6 4635 2.3 PKNOX1 RB1 MZF1 SIN3A BATF IRF4 ZNF335 GLIS2 ZNF366 SCRT2 C1orf54 APH1A SEMA6C MRPS21 CIART
GH01J150362 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +96.6 96607 5.2 CLOCK FEZF1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ZC3H11A RPRD2 SETDB1 PRPF3 SF3B4 PI4KB ZNF687 UBE2D3P3 PIP5K1A ARNT HIST2H2AB
GH01J150557 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 6.9 +301.1 301104 23.1 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC RN7SL600P MCL1 SETDB1 PIP5K1A PI4KB PRPF3 ARNT GOLPH3L HORMAD1 SF3B4
GH01J150213 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10.8 -54.4 -54359 1.5 PKNOX1 CLOCK SIN3A YY1 ELK1 ZNF207 ZNF143 RUNX3 RXRA NFYC GC01P150215 GC01P150214 SETDB1 SF3B4 ANP32E PIP5K1A PRPF3 RNU2-17P ARNT HIST2H2AB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf54 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf54 gene promoter:

Genomic Locations for C1orf54 Gene

Genomic Locations for C1orf54 Gene
chr1:150,268,200-150,280,924
(GRCh38/hg38)
Size:
12,725 bases
Orientation:
Plus strand
chr1:150,240,600-150,253,335
(GRCh37/hg19)

Genomic View for C1orf54 Gene

Genes around C1orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf54 Gene

Proteins for C1orf54 Gene

  • Protein details for C1orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWF1-CA054_HUMAN
    Recommended name:
    Uncharacterized protein C1orf54
    Protein Accession:
    Q8WWF1
    Secondary Accessions:
    • Q9H5P3

    Protein attributes for C1orf54 Gene

    Size:
    131 amino acids
    Molecular mass:
    14923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf54 Gene

Post-translational modifications for C1orf54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1orf54 Gene

Domains & Families for C1orf54 Gene

Gene Families for C1orf54 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1orf54 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf54: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf54 Gene

Function for C1orf54 Gene

Phenotypes From GWAS Catalog for C1orf54 Gene

genes like me logo Genes that share phenotypes with C1orf54: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf54 Gene

Localization for C1orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf54 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf54 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C1orf54: view

Pathways & Interactions for C1orf54 Gene

SuperPathways for C1orf54 Gene

No Data Available

Interacting Proteins for C1orf54 Gene

Gene Ontology (GO) - Biological Process for C1orf54 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf54 Gene

Drugs & Compounds for C1orf54 Gene

No Compound Related Data Available

Transcripts for C1orf54 Gene

mRNA/cDNA for C1orf54 Gene

Unigene Clusters for C1orf54 Gene

Chromosome 1 open reading frame 54:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf54 Gene

No ASD Table

Relevant External Links for C1orf54 Gene

GeneLoc Exon Structure for
C1orf54
ECgene alternative splicing isoforms for
C1orf54

Expression for C1orf54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of C1orf54 Gene:

C1orf54

SOURCE GeneReport for Unigene cluster for C1orf54 Gene:

Hs.91283

Evidence on tissue expression from TISSUES for C1orf54 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with C1orf54: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf54 Gene

Orthologs for C1orf54 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1ORF54 34
  • 98 (a)
OneToOne
C1H1orf54 33
  • 91.09 (n)
dog
(Canis familiaris)
Mammalia C17H1orf54 33
  • 87.53 (n)
cow
(Bos Taurus)
Mammalia C3H1orf54 33
  • 83.33 (n)
C1orf54 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC028528 16 34 33
  • 75.32 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf54 34
  • 30 (a)
OneToOne
Species where no ortholog for C1orf54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf54 Gene

ENSEMBL:
Gene Tree for C1orf54 (if available)
TreeFam:
Gene Tree for C1orf54 (if available)

Paralogs for C1orf54 Gene

No data available for Paralogs for C1orf54 Gene

Variants for C1orf54 Gene

Sequence variations from dbSNP and Humsavar for C1orf54 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000163033 -- 150,280,513(+) G/A intron_variant
rs1000336066 -- 150,273,175(+) G/A intron_variant
rs1001581857 -- 150,279,212(+) C/T intron_variant
rs1002580748 -- 150,277,698(+) G/T intron_variant
rs1002712264 -- 150,270,820(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf54 Gene

Variant ID Type Subtype PubMed ID
nsv1009508 CNV loss 25217958
nsv1011223 CNV gain 25217958

Variation tolerance for C1orf54 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf54 Gene

Disorders for C1orf54 Gene

Additional Disease Information for C1orf54

No disorders were found for C1orf54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf54 Gene

Publications for C1orf54 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58

Products for C1orf54 Gene

Sources for C1orf54 Gene

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