Aliases for C1orf52 Gene
Aliases for C1orf52 Gene
External Ids for C1orf52 Gene
- HGNC: 24871
- Entrez Gene: 148423
- Ensembl: ENSG00000162642
- UniProtKB: Q8N6N3
Previous GeneCards Identifiers for C1orf52 Gene
- GC01M085428
- GC01M085715
- GC01M083826
Summaries for C1orf52 Gene
GeneCards Summary for C1orf52 Gene
C1orf52 (Chromosome 1 Open Reading Frame 52) is a Protein Coding gene.
Additional gene information for C1orf52 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf52 Gene
Genomics for C1orf52 Gene
GeneHancer (GH) Regulatory Elements for C1orf52 Gene
Promoters and enhancers for C1orf52 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around C1orf52 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the C1orf52 gene promoter:
-
- HEN1
- FAC1
- Nkx6-1
- TFIID
- TBP
- POU3F2 (N-Oct-5b)
- POU3F2 (N-Oct-5a)
- POU3F2
- Roaz
Regulatory Element Products
Genomic Locations for C1orf52 Gene
Genomic Locations for C1orf52 Gene
- chr1:85,249,953-85,259,672
- (GRCh38/hg38)
- Size:
- 9,720 bases
- Orientation:
- Minus strand
- chr1:85,715,636-85,725,355
- (GRCh37/hg19)
- Size:
- 9,720 bases
- Orientation:
- Minus strand
Genomic View for C1orf52 Gene
Genes around C1orf52 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.3 by Entrez Gene
- 1p22.3 by HGNC
- 1p22.3 by Ensembl
C1orf52 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C1orf52 Gene
Proteins for C1orf52 Gene
-
Protein details for C1orf52 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N6N3-CA052_HUMAN
- Recommended name:
- UPF0690 protein C1orf52
- Protein Accession:
- Q8N6N3
- B3KX89
- Q8TDK5
- Q8TDK6
Protein attributes for C1orf52 Gene
- Size:
- 182 amino acids
- Molecular mass:
- 20599 Da
- Quaternary structure:
- No Data Available
Protein Expression for C1orf52 Gene
Post-translational modifications for C1orf52 Gene
Other Protein References for C1orf52 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C1orf52
- Invitrogen Antibodies for C1orf52 (AFLGC-C1orf52)
- Search GeneTex for Antibodies for C1orf52
Protein Products
-
OriGene Purified Proteins for C1orf52
- Search Origene for MassSpec and Protein Over-expression Lysates for C1orf52
- Origene Custom Protein Services for C1orf52
- Search GeneTex for Proteins for C1orf52
Assay Products
No data available for DME Specific Peptides for C1orf52 Gene
Domains & Families for C1orf52 Gene
Gene Families for C1orf52 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for C1orf52 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N6N3- Family:
-
- Belongs to the UPF0690 family.
Function for C1orf52 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
Phenotypes for C1orf52 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for C1orf52
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- genomics-online: gRNA clones - Search results for 39 available C1ORF52 gene related products
- Overview of 39 available C1ORF52 gene related products
- Applied Biological Materials CRISPR for C1orf52
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1orf52
- GenScript: Design CRISPR guide RNA sequences for C1orf52
miRNA for C1orf52 Gene
- miRTarBase miRNAs that target C1orf52
-
- hsa-mir-101-3p (MIRT027370)
- hsa-mir-586 (MIRT290864)
- hsa-mir-335-3p (MIRT705121)
- hsa-mir-1304-5p (MIRT705122)
- hsa-mir-6765-5p (MIRT705123)
- hsa-mir-526b-5p (MIRT705124)
- hsa-mir-6853-3p (MIRT705125)
- hsa-mir-1827 (MIRT705126)
- hsa-mir-1250-3p (MIRT705127)
- hsa-mir-5584-3p (MIRT705128)
- hsa-mir-5000-5p (MIRT705129)
- hsa-mir-148a-5p (MIRT705130)
- hsa-mir-6739-3p (MIRT720826)
- hsa-mir-4677-5p (MIRT720827)
- hsa-mir-7156-5p (MIRT720828)
- hsa-mir-4273 (MIRT720829)
- hsa-mir-6842-3p (MIRT720830)
- hsa-mir-647 (MIRT720831)
- hsa-mir-1185-2-3p (MIRT720832)
- hsa-mir-1185-1-3p (MIRT720833)
- hsa-let-7f-2-3p (MIRT720834)
- hsa-mir-4789-5p (MIRT720835)
- hsa-mir-98-3p (MIRT720836)
- hsa-let-7f-1-3p (MIRT720837)
- hsa-let-7b-3p (MIRT720838)
- hsa-let-7a-3p (MIRT720839)
- hsa-mir-22-5p (MIRT720840)
- hsa-mir-2116-5p (MIRT720841)
- hsa-mir-431-5p (MIRT720842)
- hsa-mir-4687-3p (MIRT720843)
- hsa-mir-7974 (MIRT720844)
- hsa-mir-6876-3p (MIRT720845)
- hsa-mir-626 (MIRT720846)
- hsa-mir-6757-3p (MIRT720847)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1orf52
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- genomics-online: shRNA clones - Search results for 39 available C1ORF52 gene related products
- Overview of 39 available C1ORF52 gene related products
Clone Products
- Sino Biological Human cDNA Clone for C1orf52
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- Applied Biological Materials Clones for C1orf52
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for C1orf52
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf52 Gene
Localization for C1orf52 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for C1orf52 Gene
Pathways & Interactions for C1orf52 Gene
No Data Available
Interacting Proteins for C1orf52 Gene
GPS-Prot Interaction Network for C1orf52
No data available for Pathways by source and SIGNOR curated interactions for C1orf52 Gene
Transcripts for C1orf52 Gene
mRNA/cDNA for C1orf52 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (72) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000294661 3391 bps (uc001dkw.4)
- ENST00000471115 1219 bps (uc001dkv.4)
- ENST00000493514 631 bps (uc001dkx.5)
- ENST00000344356 504 bps (uc009wcn.4)
Unigene Clusters for C1orf52 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C1orf52
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C1orf52
- genomics-online: gRNA clones - Search results for 39 available C1ORF52 gene related products
- Overview of 39 available C1ORF52 gene related products
- Applied Biological Materials CRISPR for C1orf52
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1orf52
- GenScript: Design CRISPR guide RNA sequences for C1orf52
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1orf52
- Browse OriGene Inhibitory RNA Products For C1orf52
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf52
- genomics-online: shRNA clones - Search results for 39 available C1ORF52 gene related products
- Overview of 39 available C1ORF52 gene related products
Clone Products
- Sino Biological Human cDNA Clone for C1orf52
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C1orf52
- Applied Biological Materials Clones for C1orf52
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - |
Expression for C1orf52 Gene
This gene is overexpressed in Cervix (44.9) and Lung (19.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf52 Gene
NURSA nuclear receptor signaling pathways regulating expression of C1orf52 Gene:
C1orf52SOURCE GeneReport for Unigene cluster for C1orf52 Gene:
Hs.26226mRNA Expression by UniProt/SwissProt for C1orf52 Gene:
Q8N6N3-CA052_HUMAN
Tissue specificity:
Expressed in all tissues tested including heart, placenta, liver, skeletal muscle, kidney and pancreas. Weak expression in brain and lung.
Evidence on tissue expression from TISSUES for C1orf52 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for C1orf52
- genomics-online: primer clones - Search results for 39 available C1ORF52 gene related products
- Overview of 39 available C1ORF52 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf52 Gene
Orthologs for C1orf52 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C1orf52 34 |
|
OneToOne | |
| C1H1orf52 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | C1orf52 34 |
|
OneToOne | |
| C6H1orf52 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | C1orf52 34 |
|
OneToOne | |
| C3H1orf52 33 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | RGD1560065 33 |
|
||
| mouse (Mus musculus) |
Mammalia | 2410004B18Rik 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C1orf52 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C8H1ORF52 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C1orf52 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | c1orf52 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:65873 33 |
|
||
| CZv9_NA991H1orf52 34 |
|
OneToOne | |||
| zgc65873 33 |
|
- Species where no ortholog for C1orf52 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C1orf52 Gene
No data available for Paralogs for C1orf52 Gene
Variants for C1orf52 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000228999 | -- | 85,253,500(-) | T/C | intron_variant | |
| rs1000262593 | -- | 85,259,715(-) | G/A | upstream_transcript_variant | |
| rs1001007404 | -- | 85,256,327(-) | T/C | intron_variant | |
| rs1001357051 | -- | 85,253,394(-) | C/T | intron_variant | |
| rs1001527180 | -- | 85,259,142(-) | C/G | intron_variant |
Residual Variation Intolerance Score:
42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.71;
15.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C1orf52 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C1orf52
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf52 Gene
Disorders for C1orf52 Gene
Additional Disease Information for C1orf52
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for C1orf52 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf52 Gene
Publications for C1orf52 Gene
- Identification of six novel genes by experimental validation of GeneMachine predicted genes. (PMID: 11891061) Makalowska I … Carpten JD (Gene 2002) 2 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for C1orf52 Gene
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- OriGene Purified Proteins for C1orf52
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- OriGene qPCR primer pairs for C1orf52
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- Invitrogen Antibodies for C1orf52 (AFLGC-C1orf52)
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- Overview of 39 available C1ORF52 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C1orf52
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Sources for C1orf52 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt