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Aliases for C1orf35 Gene

Aliases for C1orf35 Gene

  • Chromosome 1 Open Reading Frame 35 2 3 5
  • Multiple Myeloma Tumor-Associated Protein 2 2 3
  • Multiple Myeloma Transforming 2 3
  • HMMTAG2 4
  • MMTAG2 3

External Ids for C1orf35 Gene

Previous GeneCards Identifiers for C1orf35 Gene

  • GC01M226785
  • GC01M224027
  • GC01M224673
  • GC01M225263
  • GC01M224595
  • GC01M226355
  • GC01M228289
  • GC01M198804

Summaries for C1orf35 Gene

GeneCards Summary for C1orf35 Gene

C1orf35 (Chromosome 1 Open Reading Frame 35) is a Protein Coding gene. Among its related pathways are Innate Immune System.

Additional gene information for C1orf35 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf35 Gene

Genomics for C1orf35 Gene

GeneHancer (GH) Regulatory Elements for C1orf35 Gene

Promoters and enhancers for C1orf35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J228100 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 671.2 +2.7 2741 3.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 C1orf35 GC01P228103 ZNF678 CICP26 ENSG00000269890 CDC42BPA ARF1 OBSCN OBSCN-AS1 MIR3620
GH01J227733 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 106.1 +370.3 370319 2.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 JMJD4 SNAP47 CICP26 ZNF678 C1orf35 ENSG00000269890 CDC42BPA PRSS38 HIST3H3 LOC100126822
GH01J228781 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 96.4 -677.7 -677652 3.7 FEZF1 ZNF2 YY1 ZNF213 ZNF416 FOS KLF13 REST KAT8 MIER3 NUP133 CICP26 C1orf35 ENSG00000269890 HMGN2P19 HIST3H3 PRSS38 ABCB10 TAF5L URB2
GH01J228455 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 61.3 -352.5 -352490 4.2 CLOCK FEZF1 YY1 ZNF213 E2F8 ZNF143 SP3 ZFP41 ZNF610 GLIS1 GC01M228457 HIST3H2A HIST3H2BB CICP26 C1orf35 ENSG00000269890 ZNF678 PRSS38 HIST3H3 LOC100421842
GH01J227431 Enhancer 1.4 Ensembl ENCODE dbSUPER 67.8 +673.4 673364 1.5 PKNOX1 FOXA2 ARNT ZNF2 ZNF766 ZNF416 FOS MCM3 REST ZNF662 BTF3P9 RPS18P3 CICP26 ZNF678 C1orf35 CDC42BPA ENSG00000269890 JMJD4 HIST3H3 PSEN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf35 gene promoter:

Genomic Locations for C1orf35 Gene

Genomic Locations for C1orf35 Gene
chr1:228,100,726-228,105,411
(GRCh38/hg38)
Size:
4,686 bases
Orientation:
Minus strand
chr1:228,288,427-228,293,112
(GRCh37/hg19)

Genomic View for C1orf35 Gene

Genes around C1orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf35 Gene

Proteins for C1orf35 Gene

  • Protein details for C1orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU76-MMTA2_HUMAN
    Recommended name:
    Multiple myeloma tumor-associated protein 2
    Protein Accession:
    Q9BU76
    Secondary Accessions:
    • Q6P5Y0
    • Q6ZTZ6
    • Q6ZWA6
    • Q8IZH3

    Protein attributes for C1orf35 Gene

    Size:
    263 amino acids
    Molecular mass:
    29412 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf35 Gene

Post-translational modifications for C1orf35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf35 Gene

Domains & Families for C1orf35 Gene

Gene Families for C1orf35 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf35 Gene

Suggested Antigen Peptide Sequences for C1orf35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf35: view

No data available for UniProtKB/Swiss-Prot for C1orf35 Gene

Function for C1orf35 Gene

Phenotypes From GWAS Catalog for C1orf35 Gene

Gene Ontology (GO) - Molecular Function for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C1orf35: view
genes like me logo Genes that share phenotypes with C1orf35: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf35 Gene

Localization for C1orf35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf35 gene
Compartment Confidence
extracellular 4
nucleus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034774 secretory granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with C1orf35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C1orf35 Gene

Pathways & Interactions for C1orf35 Gene

genes like me logo Genes that share pathways with C1orf35: view

Pathways by source for C1orf35 Gene

3 Reactome pathways for C1orf35 Gene

Gene Ontology (GO) - Biological Process for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with C1orf35: view

No data available for SIGNOR curated interactions for C1orf35 Gene

Drugs & Compounds for C1orf35 Gene

No Compound Related Data Available

Transcripts for C1orf35 Gene

mRNA/cDNA for C1orf35 Gene

Unigene Clusters for C1orf35 Gene

Chromosome 1 open reading frame 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for C1orf35 Gene

GeneLoc Exon Structure for
C1orf35
ECgene alternative splicing isoforms for
C1orf35

Expression for C1orf35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf35 Gene

Protein differential expression in normal tissues from HIPED for C1orf35 Gene

This gene is overexpressed in Lung (19.6), Peripheral blood mononuclear cells (14.9), CD4 Tcells (6.9), and Pancreatic juice (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf35 Gene



Protein tissue co-expression partners for C1orf35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf35 Gene:

C1orf35

SOURCE GeneReport for Unigene cluster for C1orf35 Gene:

Hs.445952

Evidence on tissue expression from TISSUES for C1orf35 Gene

  • Blood(4.4)
  • Nervous system(4.3)
  • Lung(2.1)
  • Spleen(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with C1orf35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf35 Gene

Orthologs for C1orf35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf35 34
  • 97 (a)
OneToOne
C1H1orf35 33
  • 95.7 (n)
mouse
(Mus musculus)
Mammalia 2310033P09Rik 16 34 33
  • 81.14 (n)
rat
(Rattus norvegicus)
Mammalia RGD1304587 33
  • 80.62 (n)
cow
(Bos Taurus)
Mammalia C7H1orf35 33
  • 78.21 (n)
MMTAG2 34
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14H1orf35 33
  • 74.74 (n)
C1orf35 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf35 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf35 34
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C2H1orf35 34
  • 42 (a)
OneToOne
zgc63882 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.843 33
Species where no ortholog for C1orf35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf35 Gene

ENSEMBL:
Gene Tree for C1orf35 (if available)
TreeFam:
Gene Tree for C1orf35 (if available)

Paralogs for C1orf35 Gene

No data available for Paralogs for C1orf35 Gene

Variants for C1orf35 Gene

Sequence variations from dbSNP and Humsavar for C1orf35 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000025404 -- 228,101,697(-) A/C intron_variant
rs1000288314 -- 228,105,379(-) C/T upstream_transcript_variant
rs1000621109 -- 228,103,802(-) T/C upstream_transcript_variant
rs1000703488 -- 228,102,474(-) G/A intron_variant
rs1000756979 -- 228,104,119(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf35 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1160102 CNV deletion 26073780
nsv516409 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv826908 CNV gain 20364138
nsv832803 CNV loss 17160897
nsv952136 CNV deletion 24416366

Variation tolerance for C1orf35 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf35 Gene

Disorders for C1orf35 Gene

Additional Disease Information for C1orf35

No disorders were found for C1orf35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf35 Gene

Publications for C1orf35 Gene

  1. Cloning and sequence analysis of tumor-associated gene hMMTAG2 from human multiple myeloma cell line ARH-77. (PMID: 12545221) Tian JY … Jiang YS (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for C1orf35 Gene

Sources for C1orf35 Gene

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