Aliases for C1orf35 Gene

Aliases for C1orf35 Gene

  • Chromosome 1 Open Reading Frame 35 2 3 5
  • Multiple Myeloma Tumor-Associated Protein 2 2 3 4
  • MMTAG2 2 3
  • Multiple Myeloma Transforming 2 3
  • C1orf35 5
  • MGC4174 2
  • HMMTAG2 4

External Ids for C1orf35 Gene

Previous GeneCards Identifiers for C1orf35 Gene

  • GC01M226785
  • GC01M224027
  • GC01M224673
  • GC01M225263
  • GC01M224595
  • GC01M226355
  • GC01M228289
  • GC01M198804

Summaries for C1orf35 Gene

GeneCards Summary for C1orf35 Gene

C1orf35 (Chromosome 1 Open Reading Frame 35) is a Protein Coding gene. Among its related pathways are Innate Immune System.

Additional gene information for C1orf35 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf35 Gene

Genomics for C1orf35 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1orf35 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf35 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf35

Top Transcription factor binding sites by QIAGEN in the C1orf35 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • E4BP4
  • FosB
  • Fra-1
  • JunB
  • LCR-F1
  • SRF
  • SRF (504 AA)

Genomic Locations for C1orf35 Gene

Genomic Locations for C1orf35 Gene
chr1:228,100,726-228,105,411
(GRCh38/hg38)
Size:
4,686 bases
Orientation:
Minus strand
chr1:228,288,427-228,293,112
(GRCh37/hg19)
Size:
4,686 bases
Orientation:
Minus strand

Genomic View for C1orf35 Gene

Genes around C1orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf35 Gene

Proteins for C1orf35 Gene

  • Protein details for C1orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU76-MMTA2_HUMAN
    Recommended name:
    Multiple myeloma tumor-associated protein 2
    Protein Accession:
    Q9BU76
    Secondary Accessions:
    • Q6P5Y0
    • Q6ZTZ6
    • Q6ZWA6
    • Q8IZH3

    Protein attributes for C1orf35 Gene

    Size:
    263 amino acids
    Molecular mass:
    29412 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf35 Gene

Post-translational modifications for C1orf35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf35 Gene

Domains & Families for C1orf35 Gene

Gene Families for C1orf35 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf35 Gene

GenScript: Design optimal peptide antigens:
  • Multiple myeloma tumor-associated protein 2 (MMTA2_HUMAN)
genes like me logo Genes that share domains with C1orf35: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1orf35 Gene

Function for C1orf35 Gene

Phenotypes From GWAS Catalog for C1orf35 Gene

Gene Ontology (GO) - Molecular Function for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C1orf35: view
genes like me logo Genes that share phenotypes with C1orf35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf35

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf35 Gene

Localization for C1orf35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf35 gene
Compartment Confidence
extracellular 4
nucleus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034774 secretory granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with C1orf35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C1orf35 Gene

Pathways & Interactions for C1orf35 Gene

PathCards logo

SuperPathways for C1orf35 Gene

genes like me logo Genes that share pathways with C1orf35: view

Pathways by source for C1orf35 Gene

3 Reactome pathways for C1orf35 Gene

Gene Ontology (GO) - Biological Process for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with C1orf35: view

No data available for SIGNOR curated interactions for C1orf35 Gene

Drugs & Compounds for C1orf35 Gene

No Compound Related Data Available

Transcripts for C1orf35 Gene

mRNA/cDNA for C1orf35 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf35

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for C1orf35 Gene

GeneLoc Exon Structure for
C1orf35

Expression for C1orf35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf35 Gene

Protein differential expression in normal tissues from HIPED for C1orf35 Gene

This gene is overexpressed in Lung (19.6), Peripheral blood mononuclear cells (14.9), CD4 Tcells (6.9), and Pancreatic juice (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf35 Gene



Protein tissue co-expression partners for C1orf35 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf35

SOURCE GeneReport for Unigene cluster for C1orf35 Gene:

Hs.445952

Evidence on tissue expression from TISSUES for C1orf35 Gene

  • Blood(4.4)
  • Nervous system(4.3)
  • Spleen(2.1)
  • Lung(2.1)
  • Thyroid gland(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with C1orf35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf35 Gene

Orthologs for C1orf35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf35 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C1orf35 31
  • 97 (a)
OneToOne
C1H1orf35 30
  • 95.7 (n)
Mouse
(Mus musculus)
Mammalia 2310033P09Rik 30 17 31
  • 81.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1304587 30
  • 80.62 (n)
Cow
(Bos Taurus)
Mammalia C7H1orf35 30
  • 78.21 (n)
MMTAG2 31
  • 77 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C14H1orf35 30
  • 74.74 (n)
C1orf35 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C1orf35 31
  • 48 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C1orf35 31
  • 61 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii C2H1orf35 31
  • 42 (a)
OneToOne
zgc63882 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.843 30
Species where no ortholog for C1orf35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C1orf35 Gene

ENSEMBL:
Gene Tree for C1orf35 (if available)
TreeFam:
Gene Tree for C1orf35 (if available)

Paralogs for C1orf35 Gene

No data available for Paralogs for C1orf35 Gene

Variants for C1orf35 Gene

Additional dbSNP identifiers (rs#s) for C1orf35 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1orf35 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1160102 CNV deletion 26073780
nsv516409 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv826908 CNV gain 20364138
nsv832803 CNV loss 17160897
nsv952136 CNV deletion 24416366

Variation tolerance for C1orf35 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf35 Gene

Disorders for C1orf35 Gene

No disorders were found for C1orf35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf35 Gene

Publications for C1orf35 Gene

  1. Cloning and sequence analysis of tumor-associated gene hMMTAG2 from human multiple myeloma cell line ARH-77. (PMID: 12545221) Tian JY … Jiang YS (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for C1orf35 Gene

Sources for C1orf35 Gene