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Aliases for C1orf228 Gene

Aliases for C1orf228 Gene

  • Chromosome 1 Open Reading Frame 228 2 3 5
  • NCRNA00082 3 4
  • P40 3 4
  • Uncharacterized Protein C1orf228 3
  • Non-Protein Coding RNA 82 2

External Ids for C1orf228 Gene

Previous HGNC Symbols for C1orf228 Gene

  • NCRNA00082

Previous GeneCards Identifiers for C1orf228 Gene

  • GC01P044938
  • GC01P045140
  • GC01P043255

Summaries for C1orf228 Gene

GeneCards Summary for C1orf228 Gene

C1orf228 (Chromosome 1 Open Reading Frame 228) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for C1orf228 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf228 Gene

Genomics for C1orf228 Gene

GeneHancer (GH) Regulatory Elements for C1orf228 Gene

Promoters and enhancers for C1orf228 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I044671 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.6 +0.4 409 6.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 C1orf228 TMEM53 TOE1 MUTYH ARTN RNU5F-1 NASP KIF2C BTBD19 RPS8
GH01I044628 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 18.2 -43.2 -43213 6.6 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 POLR2B PIR47647 TOE1 DMAP1 KDM4A C1orf228 HECTD3 RPS8 MUTYH CCDC17 ARTN
GH01I044706 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.7 +32.7 32719 2.4 ELF3 PKNOX1 FOXA2 RB1 ARID4B RAD21 RARA ZNF335 ZNF121 E2F8 TMEM53 C1orf228 RNU5D-1 KIF2C RNF220 GC01P044699 GC01M044722 RNU5F-1 LOC105378690
GH01I044720 Enhancer 1.5 Ensembl ENCODE dbSUPER 8.9 +48.1 48112 4.8 MLX ZFP64 FEZF1 YBX1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GC01M044722 LOC105378690 RNU5F-1 TOE1 GPBP1L1 RPS8 RPL7AP16 MUTYH HECTD3 DMAP1
GH01I044696 Enhancer 0.8 Ensembl ENCODE 12.8 +22.6 22634 2 MEIS2 TAL1 CBFA2T3 EBF1 GABPA TCF12 POLR2A IKZF1 ETV6 IKZF2 RNU5F-1 C1orf228 TMEM53 GC01P044699 LOC105378690
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf228 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf228 gene promoter:

Genomic Locations for C1orf228 Gene

Genomic Locations for C1orf228 Gene
chr1:44,674,692-44,725,591
(GRCh38/hg38)
Size:
50,900 bases
Orientation:
Plus strand
chr1:45,140,364-45,191,263
(GRCh37/hg19)

Genomic View for C1orf228 Gene

Genes around C1orf228 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf228 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf228 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf228 Gene

Proteins for C1orf228 Gene

  • Protein details for C1orf228 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIY5-CA228_HUMAN
    Recommended name:
    Uncharacterized protein C1orf228
    Protein Accession:
    Q6PIY5
    Secondary Accessions:
    • A1KXE5

    Protein attributes for C1orf228 Gene

    Size:
    440 amino acids
    Molecular mass:
    48855 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf228 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf228 Gene

Post-translational modifications for C1orf228 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1orf228 Gene

Domains & Families for C1orf228 Gene

Gene Families for C1orf228 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf228 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf228 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf228: view

No data available for UniProtKB/Swiss-Prot for C1orf228 Gene

Function for C1orf228 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf228 Gene

Localization for C1orf228 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf228 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf228 Gene

Pathways & Interactions for C1orf228 Gene

SuperPathways for C1orf228 Gene

No Data Available

Interacting Proteins for C1orf228 Gene

Gene Ontology (GO) - Biological Process for C1orf228 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf228 Gene

Drugs & Compounds for C1orf228 Gene

No Compound Related Data Available

Transcripts for C1orf228 Gene

Unigene Clusters for C1orf228 Gene

Chromosome 1 open reading frame 228:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf228 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: -
SP10:

Relevant External Links for C1orf228 Gene

GeneLoc Exon Structure for
C1orf228
ECgene alternative splicing isoforms for
C1orf228

Expression for C1orf228 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf228 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf228 Gene

This gene is overexpressed in Whole Blood (x6.9) and Testis (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf228 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1orf228 Gene:

C1orf228

SOURCE GeneReport for Unigene cluster for C1orf228 Gene:

Hs.173679
genes like me logo Genes that share expression patterns with C1orf228: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf228 Gene

Orthologs for C1orf228 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf228 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf228 33
  • 99.39 (n)
C1orf228 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1orf228 33
  • 86.74 (n)
C1orf228 34
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C15H1orf228 33
  • 86.36 (n)
C1orf228 34
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563714 33
  • 81.89 (n)
mouse
(Mus musculus)
Mammalia Gm1661 33 16 34
  • 81.79 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf228 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf228 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8H1orf228 33
  • 64.58 (n)
C1orf228 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf228 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733444 33
  • 61.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1749 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-241d21.5 33
  • 60.92 (n)
C8H1orf228 34
  • 56 (a)
OneToOne
Dr.14941 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8705 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11040 34
  • 53 (a)
OneToOne
Species where no ortholog for C1orf228 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf228 Gene

ENSEMBL:
Gene Tree for C1orf228 (if available)
TreeFam:
Gene Tree for C1orf228 (if available)

Paralogs for C1orf228 Gene

No data available for Paralogs for C1orf228 Gene

Variants for C1orf228 Gene

Sequence variations from dbSNP and Humsavar for C1orf228 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000019955 -- 44,722,199(+) G/C coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs1000081329 -- 44,703,396(+) G/A intron_variant
rs1000106877 -- 44,692,864(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000171892 -- 44,707,696(+) A/G intron_variant
rs1000236594 -- 44,700,476(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf228 Gene

Variant ID Type Subtype PubMed ID
esv2657051 CNV deletion 23128226
esv2662778 CNV deletion 23128226
esv3577830 CNV loss 25503493
esv3585889 CNV loss 21293372
esv3585890 CNV loss 21293372
esv3585891 CNV loss 21293372
nsv478963 CNV novel sequence insertion 20440878

Variation tolerance for C1orf228 Gene

Gene Damage Index Score: 1.39; 27.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf228 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf228

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf228 Gene

Disorders for C1orf228 Gene

Additional Disease Information for C1orf228

No disorders were found for C1orf228 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf228 Gene

Publications for C1orf228 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for C1orf228 Gene

Sources for C1orf228 Gene

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