Aliases for C1orf226 Gene

Aliases for C1orf226 Gene

  • Chromosome 1 Open Reading Frame 226 2 3 5
  • Uncharacterized Protein C1orf226 3 4
  • C1orf226 5
  • FLJ13137 2

External Ids for C1orf226 Gene

Previous GeneCards Identifiers for C1orf226 Gene

  • GC01P160621
  • GC01P162348
  • GC01P133593

Summaries for C1orf226 Gene

GeneCards Summary for C1orf226 Gene

C1orf226 (Chromosome 1 Open Reading Frame 226) is a Protein Coding gene. An important paralog of this gene is NOS1AP.

Additional gene information for C1orf226 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf226 Gene

Genomics for C1orf226 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1orf226 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J162380 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 618.4 +3.3 3273 4.1 CEBPG IKZF1 JUND SP1 EP300 CEBPB MGA UBTF HMBOX1 BRCA1 C1orf226 SH2D1B UHMK1 RGS4 ENSG00000254706 lnc-SH2D1B-2
GH01J162366 Promoter 0.9 EPDnew Ensembl 600.4 -11.5 -11540 1 EGR1 KDM1A ZBTB33 ENSG00000254706 C1orf226 SPATA46 lnc-SH2D1B-3 NOS1AP
GH01J162376 Promoter 0.3 EPDnew 600.7 -2.0 -1994 0.1 C1orf226 SPATA46 lnc-SH2D1B-3 ENSG00000254706
GH01J162151 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.2 -226.3 -226290 1.7 CEBPG CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 NFKBIZ ZNF692 RCOR2 USP21 PPOX C1orf226 B4GALT3 ATF6 DUSP12 ENSG00000215840 SPATA46 MIR4654 LOC105371475
GH01J162133 Enhancer 1.1 Ensembl ENCODE dbSUPER 18 -242.3 -242258 6.4 ZNF512 POLR2A RXRB ATF7 SCRT2 ZNF792 SOX13 SP1 SMARCC1 JUND C1orf226 OLFML2B SPATA46 MIR4654 piR-32810-008 LOC105371475 NOS1AP ENSG00000254706
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf226 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf226

Top Transcription factor binding sites by QIAGEN in the C1orf226 gene promoter:
  • CREB
  • deltaCREB
  • GATA-1
  • NF-kappaB1
  • POU2F1
  • POU2F1a

Genomic Locations for C1orf226 Gene

Genomic Locations for C1orf226 Gene
chr1:162,378,841-162,386,818
(GRCh38/hg38)
Size:
7,978 bases
Orientation:
Plus strand
chr1:162,336,698-162,356,608
(GRCh37/hg19)
Size:
19,911 bases
Orientation:
Plus strand

Genomic View for C1orf226 Gene

Genes around C1orf226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf226 Gene

Proteins for C1orf226 Gene

  • Protein details for C1orf226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L170-CA226_HUMAN
    Recommended name:
    Uncharacterized protein C1orf226
    Protein Accession:
    A1L170
    Secondary Accessions:
    • B4DF31

    Protein attributes for C1orf226 Gene

    Size:
    272 amino acids
    Molecular mass:
    29057 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf226 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf226 Gene

Post-translational modifications for C1orf226 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf226 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf226 Gene

Domains & Families for C1orf226 Gene

Gene Families for C1orf226 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf226 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C1orf226: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1orf226 Gene

Function for C1orf226 Gene

Phenotypes From GWAS Catalog for C1orf226 Gene

genes like me logo Genes that share phenotypes with C1orf226: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf226

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf226 Gene

Localization for C1orf226 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf226 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf226 Gene

Pathways & Interactions for C1orf226 Gene

PathCards logo

SuperPathways for C1orf226 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf226 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf226 Gene

Drugs & Compounds for C1orf226 Gene

No Compound Related Data Available

Transcripts for C1orf226 Gene

mRNA/cDNA for C1orf226 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf226

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf226 Gene

No ASD Table

Relevant External Links for C1orf226 Gene

GeneLoc Exon Structure for
C1orf226

Expression for C1orf226 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf226 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf226 Gene

This gene is overexpressed in Pituitary (x9.3).

Protein differential expression in normal tissues from HIPED for C1orf226 Gene

This gene is overexpressed in Fetal Liver (26.6), Blymphocyte (26.4), and Liver (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf226 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf226

SOURCE GeneReport for Unigene cluster for C1orf226 Gene:

Hs.447011
genes like me logo Genes that share expression patterns with C1orf226: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf226 Gene

Orthologs for C1orf226 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf226 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C1H1orf226 30
  • 99.37 (n)
C1orf226 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C3H1orf226 30
  • 85.35 (n)
Mouse
(Mus musculus)
Mammalia Gm7694 30 17 31
  • 82.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100361087 30
  • 80.99 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101883287 30
  • 55.28 (n)
Species where no ortholog for C1orf226 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C1orf226 Gene

ENSEMBL:
Gene Tree for C1orf226 (if available)
TreeFam:
Gene Tree for C1orf226 (if available)

Paralogs for C1orf226 Gene

Paralogs for C1orf226 Gene

genes like me logo Genes that share paralogs with C1orf226: view

Variants for C1orf226 Gene

Additional dbSNP identifiers (rs#s) for C1orf226 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1orf226 Gene

Variant ID Type Subtype PubMed ID
esv2758973 CNV gain 17122850
esv34209 CNV gain 17911159
esv3587740 CNV gain 21293372
nsv516482 CNV gain+loss 19592680
nsv8513 CNV gain 18304495

Variation tolerance for C1orf226 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf226 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf226

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf226 Gene

Disorders for C1orf226 Gene

Additional Disease Information for C1orf226

No disorders were found for C1orf226 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf226 Gene

Publications for C1orf226 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
  2. The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. (PMID: 31024071) Guard SE … Old WM (Scientific reports 2019) 3
  3. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3

Products for C1orf226 Gene

Sources for C1orf226 Gene