Aliases for C1orf210 Gene

Aliases for C1orf210 Gene

  • Chromosome 1 Open Reading Frame 210 2 3 5
  • TEMP 2 3 4
  • Type III Endosome Membrane Protein TEMP 3 4
  • Type III Endosome Membrane Protein 2
  • C1orf210 5
  • MGC52423 2

External Ids for C1orf210 Gene

Previous GeneCards Identifiers for C1orf210 Gene

  • GC01M043520
  • GC01M043747
  • GC01M041867

Summaries for C1orf210 Gene

GeneCards Summary for C1orf210 Gene

C1orf210 (Chromosome 1 Open Reading Frame 210) is a Protein Coding gene. Diseases associated with C1orf210 include Thyroid Crisis and Syphilitic Encephalitis.

UniProtKB/Swiss-Prot Summary for C1orf210 Gene

  • May be involved in membrane trafficking between endosomes and plasma membrane.

Additional gene information for C1orf210 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf210 Gene

Genomics for C1orf210 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1orf210 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043283 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 608.7 +0.5 543 3.2 CTCF SP1 GABPA EGR1 CEBPB ZBTB26 ZNF444 FOXA2 POLR2A CHD2 C1orf210 CFAP57 SZT2 MPL MED8-AS1 MED8 CDC20 ENSG00000234694 ELOVL1 TMEM125
GH01J043270 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.1 +15.1 15118 2.2 CREB1 TEAD4 KDM1A POLR2A SCRT2 RFX1 EGR1 CTBP1 ZSCAN29 ZNF316 EBNA1BP2 TMEM125 lnc-EBNA1BP2-1 piR-34509 CFAP57 C1orf210 KDM4A-AS1
GH01J042929 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +346.5 346477 19 CEBPG HNRNPL GATAD2A CTCF PRDM10 ZNF629 RFX1 LEF1 IKZF1 KDM1A SLC2A1-AS1 SZT2 FOXJ3 HYI PPIH ARTN RNU6-880P KDM4A-AS1 C1orf210 ERMAP
GH01J043238 Enhancer 1 Ensembl ENCODE 8.4 +46.5 46540 2.6 GATAD2A CTCF ZNF24 RXRB REST RAD21 IRF2 IKZF2 SP1 TRIM22 TMEM125 CDC20 ENSG00000234694 ELOVL1 MPL MED8-AS1 MED8 SZT2 SZT2-AS1 HYI
GH01J043273 Enhancer 1 Ensembl ENCODE dbSUPER 7.5 +11.0 11012 2.3 RFX1 GABPA FOXJ2 CEBPA MGA CEBPB CTBP1 NR2C2 EHMT2 ELF1 CFAP57 C1orf210 CCDC24 EBNA1BP2 TMEM125 lnc-EBNA1BP2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf210 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf210

Top Transcription factor binding sites by QIAGEN in the C1orf210 gene promoter:
  • CUTL1
  • Egr-1
  • LCR-F1
  • MRF-2
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • STAT3
  • ZIC2

Genomic Locations for C1orf210 Gene

Genomic Locations for C1orf210 Gene
3,964 bases
Minus strand
3,735 bases
Minus strand

Genomic View for C1orf210 Gene

Genes around C1orf210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf210 Gene

Proteins for C1orf210 Gene

  • Protein details for C1orf210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type III endosome membrane protein TEMP
    Protein Accession:
    Secondary Accessions:
    • D3DPX2

    Protein attributes for C1orf210 Gene

    113 amino acids
    Molecular mass:
    12024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf210 Gene

Post-translational modifications for C1orf210 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for C1orf210 Gene

No data available for DME Specific Peptides for C1orf210 Gene

Domains & Families for C1orf210 Gene

Gene Families for C1orf210 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C1orf210 Gene

genes like me logo Genes that share domains with C1orf210: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1orf210 Gene

Function for C1orf210 Gene

Molecular function for C1orf210 Gene

UniProtKB/Swiss-Prot Function:
May be involved in membrane trafficking between endosomes and plasma membrane.

Phenotypes From GWAS Catalog for C1orf210 Gene

genes like me logo Genes that share phenotypes with C1orf210: view

Animal Model Products

CRISPR Products

miRNA for C1orf210 Gene

miRTarBase miRNAs that target C1orf210

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf210

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf210 Gene

Localization for C1orf210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf210 Gene

Membrane. Single-pass type III membrane protein. Early endosome. Recycling endosome. Cell membrane. Note=Also localizes to tubular endosome structures. {ECO:0000250 UniProtKB:Q9CQM1}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf210 gene
Compartment Confidence
plasma membrane 4
endosome 4
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1orf210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1orf210: view

Pathways & Interactions for C1orf210 Gene

PathCards logo

SuperPathways for C1orf210 Gene

No Data Available

Interacting Proteins for C1orf210 Gene

Gene Ontology (GO) - Biological Process for C1orf210 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf210 Gene

Drugs & Compounds for C1orf210 Gene

No Compound Related Data Available

Transcripts for C1orf210 Gene

mRNA/cDNA for C1orf210 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf210

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf210 Gene

No ASD Table

Relevant External Links for C1orf210 Gene

GeneLoc Exon Structure for

Expression for C1orf210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf210 Gene

This gene is overexpressed in Colon - Transverse (x7.8), Kidney - Cortex (x5.0), Pancreas (x4.7), and Stomach (x4.6).

Protein differential expression in normal tissues from HIPED for C1orf210 Gene

This gene is overexpressed in Fetal Liver (27.0), Pancreas (16.7), Colon (15.5), and Rectum (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf210 Gene

Protein tissue co-expression partners for C1orf210 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf210

SOURCE GeneReport for Unigene cluster for C1orf210 Gene:


Evidence on tissue expression from TISSUES for C1orf210 Gene

  • Intestine(4.5)
  • Skin(2.7)
  • Blood(2.6)
  • Nervous system(2.5)
  • Heart(2.3)
  • Muscle(2.2)
  • Kidney(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with C1orf210: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf210 Gene

Orthologs for C1orf210 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf210 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1orf210 31
  • 100 (a)
C1H1orf210 30
  • 99.71 (n)
(Bos Taurus)
Mammalia C3H1orf210 30
  • 81.12 (n)
C3H1ORF210 31
  • 73 (a)
(Rattus norvegicus)
Mammalia RGD1305347 30
  • 80.67 (n)
(Canis familiaris)
Mammalia C15H1orf210 30
  • 80.56 (n)
C1orf210 31
  • 73 (a)
(Mus musculus)
Mammalia 2610528J11Rik 30 17 31
  • 80.06 (n)
(Monodelphis domestica)
Mammalia C1orf210 31
  • 51 (a)
(Danio rerio)
Actinopterygii C6H1orf210 31
  • 15 (a)
Species where no ortholog for C1orf210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C1orf210 Gene

Gene Tree for C1orf210 (if available)
Gene Tree for C1orf210 (if available)

Paralogs for C1orf210 Gene

No data available for Paralogs for C1orf210 Gene

Variants for C1orf210 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf210 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs35465732 - p.Ser12Leu

Additional dbSNP identifiers (rs#s) for C1orf210 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1orf210 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV loss 17160897

Variation tolerance for C1orf210 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf210 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf210 Gene

Disorders for C1orf210 Gene

MalaCards: The human disease database

(14) MalaCards diseases for C1orf210 Gene - From: DISEASES

Disorder Aliases PubMed IDs
thyroid crisis
  • thyrotoxic crisis
syphilitic encephalitis
hypothalamic neoplasm
  • neoplasm of the hypothalamus
macular degeneration, age-related, 7
  • armd7
prostate calculus
  • calculus of prostate
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with C1orf210: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf210 Gene

Publications for C1orf210 Gene

  1. A Novel Type III Endosome Transmembrane Protein, TEMP. (PMID: 24710541) Aturaliya RN … Teasdale RD (Cells 2012) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A … Levine B (Nature 2011) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3

Products for C1orf210 Gene

Sources for C1orf210 Gene