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Aliases for C1orf189 Gene

Aliases for C1orf189 Gene

  • Chromosome 1 Open Reading Frame 189 2 3 5
  • Uncharacterized Protein C1orf189 3

External Ids for C1orf189 Gene

Previous GeneCards Identifiers for C1orf189 Gene

  • GC01M150985
  • GC01M152438
  • GC01M154171
  • GC01M125535

Summaries for C1orf189 Gene

GeneCards Summary for C1orf189 Gene

C1orf189 (Chromosome 1 Open Reading Frame 189) is a Protein Coding gene.

Additional gene information for C1orf189 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf189 Gene

Genomics for C1orf189 Gene

GeneHancer (GH) Regulatory Elements for C1orf189 Gene

Promoters and enhancers for C1orf189 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J154206 Promoter/Enhancer 1.1 EPDnew ENCODE 650.7 0.0 -34 0.2 MXI1 PKNOX1 RFX1 RFX3 POLR2A MYNN USF2 BMI1 C1orf189 UBAP2L
GH01J154177 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 +25.5 25485 6.8 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TPM3 UBAP2L CRTC2 CHTOP NUP210L LOC101928120 SLC27A3 FLAD1 ILF2 INTS3
GH01J153961 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.3 +243.1 243070 4 HDGF PKNOX1 SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B SLC39A1 MIR6737 ENSG00000282386 CRTC2 ILF2 CREB3L4 UBAP2L RAB13 RPS27 RPL34P5
GH01J154404 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.2 -201.0 -201017 5.8 HDGF FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IL6R IL6R-AS1 UBAP2L ATP8B2 CHTOP CLK2 INTS3 LOC101928120 ILF2 THBS3
GH01J153727 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.5 +476.9 476885 4.2 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 INTS3 UBAP2L ILF2 CRTC2 SLC27A3 CHTOP S100A1 ADAR ATP8B2 SLC39A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf189 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf189 gene promoter:
  • Pax-4a
  • Hand1
  • E47
  • Max1
  • c-Myc
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • HFH-1
  • HOXA9

Genomic Locations for C1orf189 Gene

Genomic Locations for C1orf189 Gene
chr1:154,199,085-154,206,365
(GRCh38/hg38)
Size:
7,281 bases
Orientation:
Minus strand
chr1:154,171,848-154,178,809
(GRCh37/hg19)
Size:
6,962 bases
Orientation:
Minus strand

Genomic View for C1orf189 Gene

Genes around C1orf189 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf189 Gene

Proteins for C1orf189 Gene

  • Protein details for C1orf189 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VU69-CA189_HUMAN
    Recommended name:
    Uncharacterized protein C1orf189
    Protein Accession:
    Q5VU69
    Secondary Accessions:
    • A1L4E3

    Protein attributes for C1orf189 Gene

    Size:
    101 amino acids
    Molecular mass:
    12131 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf189 Gene

Post-translational modifications for C1orf189 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf189 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf189 Gene

Domains & Families for C1orf189 Gene

Gene Families for C1orf189 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf189 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf189: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf189 Gene

Function for C1orf189 Gene

Phenotypes From GWAS Catalog for C1orf189 Gene

Gene Ontology (GO) - Molecular Function for C1orf189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C1orf189: view

Phenotypes for C1orf189 Gene

genes like me logo Genes that share phenotypes with C1orf189: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf189 Gene

Localization for C1orf189 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf189 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C1orf189 Gene

Pathways & Interactions for C1orf189 Gene

SuperPathways for C1orf189 Gene

No Data Available

Interacting Proteins for C1orf189 Gene

Gene Ontology (GO) - Biological Process for C1orf189 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf189 Gene

Drugs & Compounds for C1orf189 Gene

No Compound Related Data Available

Transcripts for C1orf189 Gene

mRNA/cDNA for C1orf189 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf189 Gene

Chromosome 1 open reading frame 189:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf189 Gene

No ASD Table

Relevant External Links for C1orf189 Gene

GeneLoc Exon Structure for
C1orf189
ECgene alternative splicing isoforms for
C1orf189

Expression for C1orf189 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf189 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf189 Gene

This gene is overexpressed in Testis (x31.6) and Cervix - Endocervix (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf189 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1orf189 Gene:

C1orf189

SOURCE GeneReport for Unigene cluster for C1orf189 Gene:

Hs.104967
genes like me logo Genes that share expression patterns with C1orf189: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf189 Gene

Orthologs for C1orf189 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf189 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf189 33
  • 99.67 (n)
C1orf189 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1orf189 34 33
  • 88.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf189 33
  • 88.45 (n)
C1orf189 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700094D03Rik 16 34 33
  • 83.17 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564171 33
  • 83.17 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf189 34
  • 58 (a)
OneToOne
Species where no ortholog for C1orf189 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf189 Gene

ENSEMBL:
Gene Tree for C1orf189 (if available)
TreeFam:
Gene Tree for C1orf189 (if available)

Paralogs for C1orf189 Gene

No data available for Paralogs for C1orf189 Gene

Variants for C1orf189 Gene

Sequence variations from dbSNP and Humsavar for C1orf189 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000280173 -- 154,202,397(-) T/C intron_variant
rs1000330786 -- 154,202,201(-) G/T intron_variant
rs1000876453 -- 154,207,026(-) A/G upstream_transcript_variant
rs1001069079 -- 154,207,362(-) G/A upstream_transcript_variant
rs1001417321 -- 154,207,659(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf189 Gene

Variant ID Type Subtype PubMed ID
nsv2954 CNV insertion 18451855

Variation tolerance for C1orf189 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf189

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf189 Gene

Disorders for C1orf189 Gene

Additional Disease Information for C1orf189

No disorders were found for C1orf189 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf189 Gene

Publications for C1orf189 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C1orf189 Gene

Sources for C1orf189 Gene

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