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Aliases for C1orf174 Gene

Aliases for C1orf174 Gene

  • Chromosome 1 Open Reading Frame 174 2 3 5
  • UPF0688 Protein C1orf174 3
  • RP13-531C17.2 3

External Ids for C1orf174 Gene

Previous GeneCards Identifiers for C1orf174 Gene

  • GC01M003829
  • GC01M003101
  • GC01M003805

Summaries for C1orf174 Gene

GeneCards Summary for C1orf174 Gene

C1orf174 (Chromosome 1 Open Reading Frame 174) is a Protein Coding gene.

Additional gene information for C1orf174 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf174 Gene

Genomics for C1orf174 Gene

GeneHancer (GH) Regulatory Elements for C1orf174 Gene

Promoters and enhancers for C1orf174 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J003899 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 745.3 -0.2 -181 2.7 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC C1orf174 LINC01134 PIR33659 PIR46444 TP73-AS1 WRAP73 ENSG00000272153 DFFB CEP104 LINC01777
GH01J003795 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.3 +104.0 103987 2.4 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B LRRC47 PIR46973 C1orf174 WRAP73 ENSG00000272153 CEP104 SMIM1
GH01J003318 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 39 +578.6 578642 6.1 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 LOC105378604 C1orf174 WRAP73 TP73-AS1 ENSG00000272153 ENSG00000233234 ENSG00000231630 RER1 CEP104 ENSG00000225931
GH01J003311 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 32.9 +586.5 586507 3.8 PKNOX1 ATF1 ARID4B ZNF2 ATF7 FOS SMARCB1 ZNF592 MAFF GMEB1 C1orf174 ENSG00000272153 TP73-AS1 WRAP73 RER1 PRDM16 LOC105378604 GC01P003290 GC01P003264
GH01J003856 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.8 +43.0 43002 2.2 HDGF SMAD1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 POLR2B ZNF207 CEP104 DFFB C1orf174 WRAP73 SMIM1 ENSG00000272153
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf174 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf174 gene promoter:
  • Lmo2
  • HNF-4alpha1
  • Meis-1b
  • Meis-1a
  • Meis-1
  • STAT5A
  • MEF-2A
  • aMEF-2
  • Msx-1

Genomic Locations for C1orf174 Gene

Genomic Locations for C1orf174 Gene
11,169 bases
Minus strand
11,169 bases
Minus strand

Genomic View for C1orf174 Gene

Genes around C1orf174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf174 Gene

Proteins for C1orf174 Gene

  • Protein details for C1orf174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0688 protein C1orf174
    Protein Accession:
    Secondary Accessions:
    • A8K0C8
    • A8MUG9
    • Q5SR20
    • Q6NX36

    Protein attributes for C1orf174 Gene

    243 amino acids
    Molecular mass:
    25977 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35643.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C1orf174 Gene

Post-translational modifications for C1orf174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf174 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf174 Gene

Domains & Families for C1orf174 Gene

Gene Families for C1orf174 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf174 Gene


Suggested Antigen Peptide Sequences for C1orf174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0688 family.
  • Belongs to the UPF0688 family.
genes like me logo Genes that share domains with C1orf174: view

Function for C1orf174 Gene

Phenotypes From GWAS Catalog for C1orf174 Gene

Gene Ontology (GO) - Molecular Function for C1orf174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with C1orf174: view

Phenotypes for C1orf174 Gene

MGI mutant phenotypes for C1orf174:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with C1orf174: view

Animal Models for C1orf174 Gene

MGI Knock Outs for C1orf174:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf174

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1orf174 Gene

Localization for C1orf174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf174 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf174 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1orf174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with C1orf174: view

Pathways & Interactions for C1orf174 Gene

SuperPathways for C1orf174 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf174 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf174 Gene

Drugs & Compounds for C1orf174 Gene

No Compound Related Data Available

Transcripts for C1orf174 Gene

mRNA/cDNA for C1orf174 Gene

Unigene Clusters for C1orf174 Gene

Chromosome 1 open reading frame 174:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf174

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf174 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for C1orf174 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf174 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf174 Gene

Protein differential expression in normal tissues from HIPED for C1orf174 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.8), CD8 Tcells (9.5), Lung (9.3), NK cells (8.4), and Monocytes (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf174 Gene

Protein tissue co-expression partners for C1orf174 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf174 Gene:


SOURCE GeneReport for Unigene cluster for C1orf174 Gene:


Evidence on tissue expression from TISSUES for C1orf174 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C1orf174: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf174 Gene

Orthologs for C1orf174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf174 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf174 34 33
  • 98.77 (n)
(Rattus norvegicus)
Mammalia RGD1304567 33
  • 74.61 (n)
(Canis familiaris)
Mammalia C5H1orf174 33
  • 73.93 (n)
C1orf174 34
  • 63 (a)
(Mus musculus)
Mammalia A430005L14Rik 16 34 33
  • 73.91 (n)
(Bos Taurus)
Mammalia C16H1orf174 34 33
  • 67.12 (n)
(Monodelphis domestica)
Mammalia C1orf174 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf174 34
  • 39 (a)
(Gallus gallus)
Aves C1orf174 34
  • 34 (a)
(Anolis carolinensis)
Reptilia C1orf174 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16480 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23827 33
(Danio rerio)
Actinopterygii C8H1orf174 34
  • 25 (a)
Species where no ortholog for C1orf174 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf174 Gene

Gene Tree for C1orf174 (if available)
Gene Tree for C1orf174 (if available)

Paralogs for C1orf174 Gene

No data available for Paralogs for C1orf174 Gene

Variants for C1orf174 Gene

Sequence variations from dbSNP and Humsavar for C1orf174 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000177534 -- 3,891,773(-) T/C coding_sequence_variant, intron_variant, synonymous_variant
rs1000256530 -- 3,900,384(-) G/C/T upstream_transcript_variant
rs1000329359 -- 3,897,389(-) A/G 5_prime_UTR_variant, intron_variant
rs1000386651 -- 3,897,049(-) G/A 5_prime_UTR_variant, intron_variant
rs1000543148 -- 3,901,240(-) C/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf174 Gene

Variant ID Type Subtype PubMed ID
esv1352346 CNV deletion 17803354
esv26417 CNV gain 19812545
esv3585042 CNV gain 21293372
esv3585052 CNV gain 21293372
nsv1012423 CNV gain 25217958
nsv474199 CNV novel sequence insertion 20440878
nsv509590 CNV insertion 20534489
nsv545130 CNV gain 21841781

Variation tolerance for C1orf174 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf174 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf174 Gene

Disorders for C1orf174 Gene

Additional Disease Information for C1orf174

No disorders were found for C1orf174 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf174 Gene

Publications for C1orf174 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for C1orf174 Gene

Sources for C1orf174 Gene

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