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Aliases for C1orf167 Gene

Aliases for C1orf167 Gene

  • Chromosome 1 Open Reading Frame 167 2 3 5

External Ids for C1orf167 Gene

Previous GeneCards Identifiers for C1orf167 Gene

  • GC01P011757
  • GC01P011744
  • GC01P011755
  • GC01P011821
  • GC01P010981

Summaries for C1orf167 Gene

GeneCards Summary for C1orf167 Gene

C1orf167 (Chromosome 1 Open Reading Frame 167) is a Protein Coding gene.

Additional gene information for C1orf167 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf167 Gene

Genomics for C1orf167 Gene

GeneHancer (GH) Regulatory Elements for C1orf167 Gene

Promoters and enhancers for C1orf167 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I011879 Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.2 +120.2 120223 4.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A POLR2B ZNF766 SP5 REST PLOD1 KIAA2013 NPPB RNU5E-1 RNU5E-4P NPPA-AS1 LOC102724659 C1orf167 LOC390997 ENSG00000226849
GH01I011707 Enhancer 1.1 ENCODE dbSUPER 11.3 -54.2 -54150 0.7 HDGF NFIB ARNT NFRKB FEZF1 ZNF766 GLIS2 POLR3A SCRT2 ZNF548 EXOSC10 TARDBP AGTRAP ENSG00000226849 MTOR FBXO2 FBXO44 C1orf167 LOC102724659 MTHFR
GH01I011705 Enhancer 0.7 dbSUPER 11.3 -55.3 -55263 1.1 BCOR NFRKB ZMYM3 CEBPG E2F1 ZNF335 POLR2A POLR3A ADNP PRDM10 AGTRAP MTOR FBXO2 FBXO44 C1orf167 LOC102724659 ENSG00000271895 EXOSC10 C1orf127 MAD2L2
GH01I011704 Enhancer 0.7 ENCODE dbSUPER 11.3 -57.4 -57358 0.1 PKNOX1 PBX2 EZH2 ZBTB20 AGTRAP FBXO2 FBXO44 C1orf167 LOC102724659 C1orf127 MAD2L2 GC01P011722 DRAXIN
GH01I011872 Enhancer 0.6 dbSUPER 10.5 +112.2 112200 3.7 CTCF RFX1 NR2F1 ZNF384 PRDM10 NR2F6 FOS RARA RNU5E-1 RNU5E-4P NPPA-AS1 MFN2 PLOD1 KIAA2013 LOC102724659 C1orf167 MTHFR LOC390997
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf167 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf167 gene promoter:

Genomic Locations for C1orf167 Gene

Genomic Locations for C1orf167 Gene
chr1:11,761,787-11,789,585
(GRCh38/hg38)
Size:
27,799 bases
Orientation:
Plus strand
chr1:11,821,844-11,849,642
(GRCh37/hg19)

Genomic View for C1orf167 Gene

Genes around C1orf167 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf167 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf167 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf167 Gene

Proteins for C1orf167 Gene

  • Protein details for C1orf167 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SNV9-CA167_HUMAN
    Recommended name:
    Uncharacterized protein C1orf167
    Protein Accession:
    Q5SNV9
    Secondary Accessions:
    • Q8NDA9
    • Q8NDF3

    Protein attributes for C1orf167 Gene

    Size:
    1468 amino acids
    Molecular mass:
    162423 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI15881.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C1orf167 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf167 Gene

Post-translational modifications for C1orf167 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1orf167 Gene

Domains & Families for C1orf167 Gene

Gene Families for C1orf167 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf167 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf167: view

No data available for UniProtKB/Swiss-Prot for C1orf167 Gene

Function for C1orf167 Gene

Phenotypes From GWAS Catalog for C1orf167 Gene

genes like me logo Genes that share phenotypes with C1orf167: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf167 Gene

Localization for C1orf167 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf167 gene
Compartment Confidence
nucleus 2
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C1orf167 Gene

Pathways & Interactions for C1orf167 Gene

SuperPathways for C1orf167 Gene

No Data Available

Interacting Proteins for C1orf167 Gene

Gene Ontology (GO) - Biological Process for C1orf167 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf167 Gene

Drugs & Compounds for C1orf167 Gene

No Compound Related Data Available

Transcripts for C1orf167 Gene

Unigene Clusters for C1orf167 Gene

Chromosome 1 open reading frame 167:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf167 Gene

No ASD Table

Relevant External Links for C1orf167 Gene

GeneLoc Exon Structure for
C1orf167
ECgene alternative splicing isoforms for
C1orf167

Expression for C1orf167 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf167 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf167 Gene

This gene is overexpressed in Testis (x50.8).

Protein differential expression in normal tissues from HIPED for C1orf167 Gene

This gene is overexpressed in Esophagus (34.9), Platelet (14.9), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf167 Gene



Protein tissue co-expression partners for C1orf167 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf167 Gene:

C1orf167

SOURCE GeneReport for Unigene cluster for C1orf167 Gene:

Hs.585415
genes like me logo Genes that share expression patterns with C1orf167: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf167 Gene

Orthologs for C1orf167 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf167 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC737382 33
  • 98.04 (n)
C1orf167 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf167 34
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf167 34
  • 30 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf167 34
  • 28 (a)
OneToOne
Species where no ortholog for C1orf167 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf167 Gene

ENSEMBL:
Gene Tree for C1orf167 (if available)
TreeFam:
Gene Tree for C1orf167 (if available)

Paralogs for C1orf167 Gene

(1) SIMAP similar genes for C1orf167 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with C1orf167: view

No data available for Paralogs for C1orf167 Gene

Variants for C1orf167 Gene

Sequence variations from dbSNP and Humsavar for C1orf167 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1013898996 uncertain-significance, Neural tube defects, folate-sensitive 11,786,639(+) C/T intron_variant
rs1037008508 uncertain-significance, Neural tube defects, folate-sensitive 11,787,522(+) C/A/T intron_variant
rs11559040 likely-benign, Neural tube defects, folate-sensitive 11,788,082(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs116013353 uncertain-significance, Neural tube defects, folate-sensitive 11,787,879(+) G/A coding_sequence_variant, missense_variant
rs116698217 uncertain-significance, Neural tube defects, folate-sensitive 11,787,875(+) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf167 Gene

Variant ID Type Subtype PubMed ID
nsv508880 CNV insertion 20534489
nsv832758 CNV loss 17160897

Variation tolerance for C1orf167 Gene

Gene Damage Index Score: 14.54; 96.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf167 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf167

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf167 Gene

Disorders for C1orf167 Gene

Additional Disease Information for C1orf167

No disorders were found for C1orf167 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf167 Gene

Publications for C1orf167 Gene

  1. Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. (PMID: 12370778) Tran P … Rozen R (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 2 3 58
  2. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. (PMID: 23824729) van Meurs JB … Ahmadi KR (The American journal of clinical nutrition 2013) 3 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 58
  4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 58
  5. Candidate gene polymorphisms for ischemic stroke. (PMID: 19729601) Matarin M … Meschia JF (Stroke 2009) 3 58

Products for C1orf167 Gene

Sources for C1orf167 Gene

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