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Aliases for C1orf162 Gene

Aliases for C1orf162 Gene

  • Chromosome 1 Open Reading Frame 162 2 3 5

External Ids for C1orf162 Gene

Previous GeneCards Identifiers for C1orf162 Gene

  • GC01P111729
  • GC01P111818
  • GC01P112016
  • GC01P109888

Summaries for C1orf162 Gene

GeneCards Summary for C1orf162 Gene

C1orf162 (Chromosome 1 Open Reading Frame 162) is a Protein Coding gene.

Additional gene information for C1orf162 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf162 Gene

Genomics for C1orf162 Gene

GeneHancer (GH) Regulatory Elements for C1orf162 Gene

Promoters and enhancers for C1orf162 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I111473 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.4 +8.3 8326 5.5 HDGF PKNOX1 BATF ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CBFB JUNB C1orf162 ENSG00000260948 OVGP1 KRT18P57 RNU6-151P PGCP1 FAM212B DDX20 GC01M111493 RNU6-792P
GH01I111502 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.8 +39.4 39381 8.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ADORA3 C1orf162 RAP1A DDX20 CEPT1 FAM212B DRAM2 TMIGD3
GH01I111591 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +125.8 125775 3.2 HDGF HNRNPUL1 SMAD1 ARNT FEZF1 YBX1 ZNF207 ZNF143 FOS KLF13 DDX20 RAP1A DENND2D TMIGD3 ADORA3 C1orf162 FAM212B OVGP1 LINC01160 GC01P111550
GH01I111601 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 +136.2 136236 4.6 HDGF PKNOX1 SMAD1 RB1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 FAM212B RAP1A KRT18P57 RNU6-151P DDX20 C1orf162 LINC01160 PIFO TMIGD3 GC01P111550
GH01I111599 Enhancer 1.1 ENCODE dbSUPER 10.2 +132.6 132563 1.2 HDAC1 PKNOX1 RB1 ARNT BATF CHAMP1 TCF12 CBX5 EGR1 ZNF143 KRT18P57 RNU6-151P DDX20 FAM212B C1orf162 RAP1A LINC01160 TMIGD3 GC01P111550
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf162 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf162 gene promoter:

Genomic Locations for C1orf162 Gene

Genomic Locations for C1orf162 Gene
chr1:111,467,487-111,478,512
(GRCh38/hg38)
Size:
11,026 bases
Orientation:
Plus strand
chr1:112,016,414-112,021,134
(GRCh37/hg19)

Genomic View for C1orf162 Gene

Genes around C1orf162 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf162 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf162 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf162 Gene

Proteins for C1orf162 Gene

  • Protein details for C1orf162 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEQ5-CA162_HUMAN
    Recommended name:
    Transmembrane protein C1orf162
    Protein Accession:
    Q8NEQ5
    Secondary Accessions:
    • Q5QNZ1

    Protein attributes for C1orf162 Gene

    Size:
    155 amino acids
    Molecular mass:
    16886 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf162 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf162 Gene

Post-translational modifications for C1orf162 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf162 Gene

No data available for DME Specific Peptides for C1orf162 Gene

Domains & Families for C1orf162 Gene

Gene Families for C1orf162 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C1orf162 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C1orf162 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf162: view

No data available for UniProtKB/Swiss-Prot for C1orf162 Gene

Function for C1orf162 Gene

Phenotypes From GWAS Catalog for C1orf162 Gene

genes like me logo Genes that share phenotypes with C1orf162: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf162 Gene

Localization for C1orf162 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf162 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf162 gene
Compartment Confidence
plasma membrane 2
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C1orf162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1orf162: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1orf162 Gene

Pathways & Interactions for C1orf162 Gene

SuperPathways for C1orf162 Gene

No Data Available

Interacting Proteins for C1orf162 Gene

Selected Interacting proteins: Q8NEQ5-CA162_HUMAN for C1orf162 Gene via IID

Symbol External ID(s) Details
FGL2
MYO1F

Gene Ontology (GO) - Biological Process for C1orf162 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf162 Gene

Drugs & Compounds for C1orf162 Gene

No Compound Related Data Available

Transcripts for C1orf162 Gene

Unigene Clusters for C1orf162 Gene

Chromosome 1 open reading frame 162:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf162 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - -

Relevant External Links for C1orf162 Gene

GeneLoc Exon Structure for
C1orf162
ECgene alternative splicing isoforms for
C1orf162

Expression for C1orf162 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf162 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf162 Gene

This gene is overexpressed in Whole Blood (x26.8).

Protein differential expression in normal tissues from HIPED for C1orf162 Gene

This gene is overexpressed in NK cells (30.6), Platelet (19.8), and Blymphocyte (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf162 Gene



Protein tissue co-expression partners for C1orf162 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf162 Gene:

C1orf162

SOURCE GeneReport for Unigene cluster for C1orf162 Gene:

Hs.288010

Evidence on tissue expression from TISSUES for C1orf162 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with C1orf162: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf162 Gene

Orthologs for C1orf162 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf162 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf162 33 34
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia C3H1orf162 33
  • 75.38 (n)
mouse
(Mus musculus)
Mammalia I830077J02Rik 33 16 34
  • 73.81 (n)
rat
(Rattus norvegicus)
Mammalia LOC100363228 33
  • 73.6 (n)
dog
(Canis familiaris)
Mammalia C17H1orf162 33
  • 66.17 (n)
C1ORF162 34
  • 39 (a)
OneToOne
Species where no ortholog for C1orf162 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf162 Gene

ENSEMBL:
Gene Tree for C1orf162 (if available)
TreeFam:
Gene Tree for C1orf162 (if available)

Paralogs for C1orf162 Gene

No data available for Paralogs for C1orf162 Gene

Variants for C1orf162 Gene

Sequence variations from dbSNP and Humsavar for C1orf162 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000014423 -- 111,465,642(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000095505 -- 111,461,111(+) A/T upstream_transcript_variant
rs1000376188 -- 111,466,803(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000707329 -- 111,465,404(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001000095 -- 111,474,309(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf162 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV loss 19166990
nsv547535 CNV loss 21841781

Variation tolerance for C1orf162 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.56; 77.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf162 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf162

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf162 Gene

Disorders for C1orf162 Gene

Additional Disease Information for C1orf162

No disorders were found for C1orf162 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf162 Gene

Publications for C1orf162 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson AD … Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (Diabetes 2010) 44 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for C1orf162 Gene

Sources for C1orf162 Gene

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