Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C1orf158 Gene

Aliases for C1orf158 Gene

  • Chromosome 1 Open Reading Frame 158 2 3 5

External Ids for C1orf158 Gene

Previous GeneCards Identifiers for C1orf158 Gene

  • GC01P012741
  • GC01P011959

Summaries for C1orf158 Gene

GeneCards Summary for C1orf158 Gene

C1orf158 (Chromosome 1 Open Reading Frame 158) is a Protein Coding gene.

Additional gene information for C1orf158 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf158 Gene

Genomics for C1orf158 Gene

GeneHancer (GH) Regulatory Elements for C1orf158 Gene

Promoters and enhancers for C1orf158 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I012746 Promoter 0.9 EPDnew 550.8 0.0 -5 0.1 HDAC1 RFX1 MAFG ZEB2 BMI1 EP300 ZNF217 ADNP RUNX3 NR2C2 C1orf158 AADACL3
GH01I012721 Enhancer 0.2 FANTOM5 0.3 -24.5 -24513 0.2 AADACL4 AADACL3 C1orf158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf158 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf158 gene promoter:

Genomic Locations for C1orf158 Gene

Genomic Locations for C1orf158 Gene
17,514 bases
Plus strand

Genomic View for C1orf158 Gene

Genes around C1orf158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf158 Gene

Proteins for C1orf158 Gene

  • Protein details for C1orf158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C1orf158
    Protein Accession:
    Secondary Accessions:
    • Q5VUY4

    Protein attributes for C1orf158 Gene

    194 amino acids
    Molecular mass:
    23067 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf158 Gene

Post-translational modifications for C1orf158 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf158 Gene

No data available for DME Specific Peptides for C1orf158 Gene

Domains & Families for C1orf158 Gene

Gene Families for C1orf158 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf158 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf158: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf158 Gene

Function for C1orf158 Gene

Phenotypes for C1orf158 Gene

genes like me logo Genes that share phenotypes with C1orf158: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf158 Gene

Localization for C1orf158 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf158 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf158 Gene

Pathways & Interactions for C1orf158 Gene

SuperPathways for C1orf158 Gene

No Data Available

Interacting Proteins for C1orf158 Gene

Gene Ontology (GO) - Biological Process for C1orf158 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf158 Gene

Drugs & Compounds for C1orf158 Gene

No Compound Related Data Available

Transcripts for C1orf158 Gene

Unigene Clusters for C1orf158 Gene

Chromosome 1 open reading frame 158:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf158 Gene

No ASD Table

Relevant External Links for C1orf158 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf158 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf158 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf158 Gene

This gene is overexpressed in Testis (x34.5) and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for C1orf158 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf158 Gene

Protein tissue co-expression partners for C1orf158 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf158 Gene:


SOURCE GeneReport for Unigene cluster for C1orf158 Gene:

genes like me logo Genes that share expression patterns with C1orf158: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf158 Gene

Orthologs for C1orf158 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf158 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf158 33
  • 99.66 (n)
C1orf158 34
  • 99 (a)
(Bos Taurus)
Mammalia C16H1orf158 33 34
  • 82.21 (n)
(Canis familiaris)
Mammalia C2H1orf158 33
  • 80.48 (n)
C1orf158 34
  • 72 (a)
(Mus musculus)
Mammalia 1700012P22Rik 33 16 34
  • 78.87 (n)
(Rattus norvegicus)
Mammalia LOC691162 33
  • 78.82 (n)
(Monodelphis domestica)
Mammalia C1orf158 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf158 34
  • 51 (a)
(Gallus gallus)
Aves C21H1orf158 33 34
  • 56.28 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490433 33
  • 50 (n)
(Danio rerio)
Actinopterygii LOC100003307 33
  • 50.1 (n)
C11H1orf158 34
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for C1orf158 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf158 Gene

Gene Tree for C1orf158 (if available)
Gene Tree for C1orf158 (if available)

Paralogs for C1orf158 Gene

No data available for Paralogs for C1orf158 Gene

Variants for C1orf158 Gene

Sequence variations from dbSNP and Humsavar for C1orf158 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000832283 -- 12,760,537(+) C/T intron_variant
rs1000899706 -- 12,746,870(+) T/C intron_variant
rs1000954203 -- 12,753,192(+) C/T intron_variant
rs1001026343 -- 12,752,836(+) T/G intron_variant
rs1001090715 -- 12,748,624(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf158 Gene

Variant ID Type Subtype PubMed ID
dgv19n100 CNV loss 25217958
esv2664000 CNV deletion 23128226
esv3585239 CNV loss 21293372
nsv1000876 CNV gain 25217958
nsv1011540 CNV loss 25217958
nsv466394 CNV gain 19166990
nsv470695 CNV loss 18288195
nsv528703 CNV loss 19592680
nsv545445 CNV gain 21841781
nsv832869 CNV gain+loss 17160897
nsv999658 CNV gain 25217958

Variation tolerance for C1orf158 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf158 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf158 Gene

Disorders for C1orf158 Gene

Additional Disease Information for C1orf158

No disorders were found for C1orf158 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf158 Gene

Publications for C1orf158 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for C1orf158 Gene

Sources for C1orf158 Gene

Loading form....