Aliases for C1orf146 Gene

Aliases for C1orf146 Gene

  • Chromosome 1 Open Reading Frame 146 2 3 5
  • Synaptonemal Complex Reinforcing Element 3 4
  • Protein SPO16 Homolog 3 4
  • SPO16 2 3
  • SCRE 3 4
  • Uncharacterized Protein C1orf146 3
  • C1orf146 5

External Ids for C1orf146 Gene

Previous GeneCards Identifiers for C1orf146 Gene

  • GC01P092397
  • GC01P092456
  • GC01P092683
  • GC01P090803

Summaries for C1orf146 Gene

GeneCards Summary for C1orf146 Gene

C1orf146 (Chromosome 1 Open Reading Frame 146) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for C1orf146 Gene

  • Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (By similarity). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (By similarity). Required for the localization of TEX11 and MSH4 to recombination intermediates (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf146 Gene

Genomics for C1orf146 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1orf146 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J092229 Promoter 0.3 EPDnew 250.4 +11.2 11213 0.1 ACTBP12 C1orf146 RPAP2
GH01J092184 Enhancer 0.3 Ensembl 11.7 -33.2 -33214 1.4 CEBPB HSALNG0005189 C1orf146 DIPK1A HSALNG0005191 BTBD8
GH01J092174 Enhancer 0.2 Ensembl 10.9 -43.2 -43214 0.2 C1orf146 HSALNG0005189 RF00017-232 BTBD8
GH01J092297 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +80.8 80786 3.8 ZNF207 MYC ZNF600 ZNF580 POLR2A ZSCAN16 ZIC2 ZBTB10 YY1 MXD4 RPAP2 lnc-GLMN-1 GLMN DIPK1A EVI5 piR-31758 C1orf146
GH01J092079 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 -137.2 -137214 2.2 ZNF600 POLR2A ZIC2 ZBTB10 YY1 NONO SMAD5 MBD2 ZNF341 MNT BTBD8 RPAP2 SNORA66 SNORD21 RPL5 GAPDHP46 C1orf146
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf146 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf146

Genomic Locations for C1orf146 Gene

Latest Assembly
chr1:92,217,915-92,245,813
(GRCh38/hg38)
Size:
27,899 bases
Orientation:
Plus strand

Previous Assembly
chr1:92,683,472-92,711,370
(GRCh37/hg19 by Entrez Gene)
Size:
27,899 bases
Orientation:
Plus strand

chr1:92,683,497-92,711,370
(GRCh37/hg19 by Ensembl)
Size:
27,874 bases
Orientation:
Plus strand

Genomic View for C1orf146 Gene

Genes around C1orf146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf146 Gene

Proteins for C1orf146 Gene

  • Protein details for C1orf146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVC0-SPO16_HUMAN
    Recommended name:
    Protein SPO16 homolog
    Protein Accession:
    Q5VVC0
    Secondary Accessions:
    • Q5VVC4

    Protein attributes for C1orf146 Gene

    Size:
    180 amino acids
    Molecular mass:
    20418 Da
    Quaternary structure:
    • Homooligomer (By similarity). Interacts with SHOC, SYCP1 and SYCE3 (By similarity).

neXtProt entry for C1orf146 Gene

Post-translational modifications for C1orf146 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf146 Gene

No data available for DME Specific Peptides for C1orf146 Gene

Domains & Families for C1orf146 Gene

Gene Families for C1orf146 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf146 Gene

InterPro:
genes like me logo Genes that share domains with C1orf146: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1orf146 Gene

Function for C1orf146 Gene

Molecular function for C1orf146 Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (By similarity). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (By similarity). Required for the localization of TEX11 and MSH4 to recombination intermediates (By similarity).

Phenotypes From GWAS Catalog for C1orf146 Gene

genes like me logo Genes that share phenotypes with C1orf146: view

miRNA for C1orf146 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf146

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf146 Gene

Localization for C1orf146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf146 Gene

Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf146 gene
Compartment Confidence
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C1orf146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome ISS --
genes like me logo Genes that share ontologies with C1orf146: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1orf146 Gene

Pathways & Interactions for C1orf146 Gene

PathCards logo

SuperPathways for C1orf146 Gene

No Data Available

Interacting Proteins for C1orf146 Gene

Gene Ontology (GO) - Biological Process for C1orf146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007130 synaptonemal complex assembly ISS --
GO:0007131 reciprocal meiotic recombination ISS --
genes like me logo Genes that share ontologies with C1orf146: view

No data available for Pathways by source and SIGNOR curated interactions for C1orf146 Gene

Drugs & Compounds for C1orf146 Gene

No Compound Related Data Available

Transcripts for C1orf146 Gene

mRNA/cDNA for C1orf146 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf146

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf146 Gene

No ASD Table

Relevant External Links for C1orf146 Gene

GeneLoc Exon Structure for
C1orf146

Expression for C1orf146 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf146 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf146 Gene

This gene is overexpressed in Testis (x22.9), Brain - Cerebellar Hemisphere (x5.2), and Brain - Cerebellum (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf146

SOURCE GeneReport for Unigene cluster for C1orf146 Gene:

Hs.558823
genes like me logo Genes that share expression patterns with C1orf146: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf146 Gene

Orthologs for C1orf146 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf146 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C1H1orf146 29
  • 100 (n)
C1orf146 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C3H1orf146 29
  • 93.33 (n)
C1orf146 30
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C6H1orf146 29
  • 92.78 (n)
C1orf146 30
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 1700028K03Rik 29 16 30
  • 85.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC689986 29
  • 84.92 (n)
Oppossum
(Monodelphis domestica)
Mammalia C1orf146 30
  • 51 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C1ORF146 29 30
  • 66.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C1orf146 30
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101733338 29
  • 63.92 (n)
Zebrafish
(Danio rerio)
Actinopterygii gb:ex154042 29
  • 50.46 (n)
C6H1orf146 30
  • 40 (a)
OneToOne
Species where no ortholog for C1orf146 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C1orf146 Gene

ENSEMBL:
Gene Tree for C1orf146 (if available)
TreeFam:
Gene Tree for C1orf146 (if available)
Alliance of Genome Resources:
Additional Orthologs for C1orf146

Paralogs for C1orf146 Gene

Pseudogenes.org Pseudogenes for C1orf146 Gene

genes like me logo Genes that share paralogs with C1orf146: view

No data available for Paralogs for C1orf146 Gene

Variants for C1orf146 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C1orf146 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C1orf146 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV deletion 23290073
nsv830592 CNV gain 17160897
nsv946075 CNV duplication 23825009

Variation tolerance for C1orf146 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf146 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf146
Leiden Open Variation Database (LOVD)
C1orf146

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf146 Gene

Disorders for C1orf146 Gene

Additional Disease Information for C1orf146

No disorders were found for C1orf146 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf146 Gene

Publications for C1orf146 Gene

  1. SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. (PMID: 30746471) Zhang Q … Yu C (Science advances 2019) 2 3
  2. LOC689986, a unique gene showing specific expression in restricted areas of the rodent neocortex. (PMID: 23844656) Ersland KM … Steen VM (BMC neuroscience 2013) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Finishing the euchromatic sequence of the human genome. (PMID: 15496913) International Human Genome Sequencing Consortium (Nature 2004) 3

Products for C1orf146 Gene

Sources for C1orf146 Gene