C1orf141 Gene (Protein Coding)

Chromosome 1 Open Reading Frame 141

GC01M067092
GIFtS:
27
See more...

Aliases for C1orf141 Gene

Aliases for C1orf141 Gene

  • Chromosome 1 Open Reading Frame 141 2 3 5
  • Uncharacterized Protein C1orf141 3 4
  • C1orf141 5

External Ids for C1orf141 Gene

Previous GeneCards Identifiers for C1orf141 Gene

  • GC01M067271
  • GC01M067557
  • GC01M065666

Summaries for C1orf141 Gene

GeneCards Summary for C1orf141 Gene

C1orf141 (Chromosome 1 Open Reading Frame 141) is a Protein Coding gene. Diseases associated with C1orf141 include Schneckenbecken Dysplasia and Posterior Scleritis.

Additional gene information for C1orf141 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf141 Gene

Genomics for C1orf141 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for C1orf141 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J067134 Promoter 1.3 EPDnew Ensembl CraniofacialAtlas 615 +97.0 96952 1 POLR2A CEBPB CEBPG SIN3A ZBTB33 C1orf141 lnc-SLC35D1-9 ENSG00000252433 RNU6-586P IL23R ENSG00000275678 SLC35D1
GH01J067230 Enhancer 0.2 Ensembl 600.7 +1.0 1006 1.1 C1orf141 RF00026-047 RNU6-586P NONHSAG001750.2 IL23R
GH01J067170 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 21.2 +60.2 60152 3 GATAD2A IKZF2 ZNF740 SP1 YY1 CEBPA EED ARID3A ZNF766 HMBOX1 IL23R C1orf141 RNU6-586P ENSG00000252433 SLC35D1 piR-39341-005 piR-32810-001
GH01J067052 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 +178.9 178939 4.2 HNRNPL GATAD2A PRDM10 ZNF629 ZNF692 POLR2A BACH1 TARDBP FOXA1 LARP7 SLC35D1 C1orf141 ENSG00000252433 DNAI4 MN308949 MIER1
GH01J067191 Enhancer 1 Ensembl ENCODE 20.4 +39.7 39725 2.1 IKZF1 JUND MTA2 PKNOX1 MTA1 ZNF24 DPF2 HDAC1 SOX6 FOXJ2 C1orf141 MIER1 RF00026-047 RNU6-586P NONHSAG001750.2 IL23R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf141 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf141

Top Transcription factor binding sites by QIAGEN in the C1orf141 gene promoter:
  • AREB6
  • POU2F1
  • POU2F1a

Genomic Locations for C1orf141 Gene

Genomic Locations for C1orf141 Gene
chr1:67,092,165-67,231,853
(GRCh38/hg38)
Size:
139,689 bases
Orientation:
Minus strand
chr1:67,557,848-67,697,536
(GRCh37/hg19)
Size:
139,689 bases
Orientation:
Minus strand

Genomic View for C1orf141 Gene

Genes around C1orf141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf141 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C1orf141 Gene

Proteins for C1orf141 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for C1orf141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JVX7-CA141_HUMAN
    Recommended name:
    Uncharacterized protein C1orf141
    Protein Accession:
    Q5JVX7
    Secondary Accessions:
    • Q0P5P5
    • Q5JVX5

    Protein attributes for C1orf141 Gene

    Size:
    400 amino acids
    Molecular mass:
    46135 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf141 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf141 Gene

Protein Expression for C1orf141 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for C1orf141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf141 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf141 Gene

Domains & Families for C1orf141 Gene

Gene Families for C1orf141 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf141 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C1orf141: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1orf141 Gene

Function for C1orf141 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for C1orf141 Gene

Phenotypes for C1orf141 Gene

GenomeRNAi human phenotypes for C1orf141:
genes like me logo Genes that share phenotypes with C1orf141: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf141

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf141 Gene

Localization for C1orf141 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf141 gene
Compartment Confidence
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf141 Gene

Pathways & Interactions for C1orf141 Gene

PathCards logo

SuperPathways for C1orf141 Gene

No Data Available

Interacting Proteins for C1orf141 Gene

Gene Ontology (GO) - Biological Process for C1orf141 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf141 Gene

Drugs & Compounds for C1orf141 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for C1orf141 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for C1orf141 Gene

3 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf141

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf141 Gene

No ASD Table

Relevant External Links for C1orf141 Gene

GeneLoc Exon Structure for
C1orf141

Expression for C1orf141 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf141 Gene

mRNA expression in normal human tissues for C1orf141 Gene
mRNA expression by GTEx for C1orf141 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf141 Gene

This gene is overexpressed in Testis (x27.1).

Protein differential expression in normal tissues from HIPED for C1orf141 Gene

This gene is overexpressed in Brain (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf141 Gene



Protein tissue co-expression partners for C1orf141 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf141

SOURCE GeneReport for Unigene cluster for C1orf141 Gene:

Hs.666621
genes like me logo Genes that share expression patterns with C1orf141: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf141 Gene

Orthologs for C1orf141 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf141 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia C1orf141 31
  • 99 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia C1orf141 31
  • 54 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia C1orf141 31
  • 50 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia 4921539E11Rik 31
  • 33 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia C1orf141 31
  • 22 (a)
 OneToOne
Species where no ortholog for C1orf141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C1orf141 Gene

ENSEMBL:
Gene Tree for C1orf141 (if available)
TreeFam:
Gene Tree for C1orf141 (if available)

Paralogs for C1orf141 Gene

No data available for Paralogs for C1orf141 Gene

Variants for C1orf141 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf141 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
778232 Benign: not provided 67,093,186(-) CTCATT/C FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
rs11208997 - p.Val189Ile
rs2273682 - p.Glu85Gly

Additional dbSNP identifiers (rs#s) for C1orf141 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1orf141 Gene

Variant ID Type Subtype PubMed ID
esv3586304 CNV loss 21293372
nsv461751 CNV loss 19166990
nsv461762 CNV gain 19166990
nsv546445 CNV loss 21841781
nsv546446 CNV gain 21841781

Variation tolerance for C1orf141 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf141 Gene

Human Gene Mutation Database (HGMD)
C1orf141
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf141 Gene

Disorders for C1orf141 Gene

MalaCards: The human disease database

(3) MalaCards diseases for C1orf141 Gene - From: DISEASES

Disorder Aliases PubMed IDs
schneckenbecken dysplasia
  • shnknd
posterior scleritis
behcet syndrome
  • behcet disease; bd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C1orf141

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with C1orf141: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf141 Gene

Publications for C1orf141 Gene

  1. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PMID: 22019778) Zhang F … Zhang X (Nature genetics 2011) 3 41
  2. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H … Zhang F (Nature genetics 2015) 3
  3. Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3. (PMID: 25108386) Hou S … Yang P (Nature genetics 2014) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3
  5. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3

ExternalLinks

View latest publications for C1orf141 gene in Mastermind

Products for C1orf141 Gene

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