Aliases for C1orf141 Gene
External Ids for C1orf141 Gene
- HGNC: 32044
- Entrez Gene: 400757
- Ensembl: ENSG00000203963
- UniProtKB: Q5JVX7
Previous GeneCards Identifiers for C1orf141 Gene
- GC01M067271
- GC01M067557
- GC01M065666
Summaries for C1orf141 Gene
GeneCards Summary for C1orf141 Gene
C1orf141 (Chromosome 1 Open Reading Frame 141) is a Protein Coding gene.
Additional gene information for C1orf141 Gene
- Monarch Initiative
- Search for C1orf141 at DataMed
- Search for C1orf141 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf141 Gene
Genomics for C1orf141 Gene
GeneHancer (GH) Regulatory Elements for C1orf141 Gene
Promoters and enhancers for C1orf141 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I067131 | Promoter | 0.5 | EPDnew | 550.1 | +100.3 | 100281 | 0.1 | C1orf141 IL23R ENSG00000275678 | ||
| GH01I067191 | Enhancer | 0.9 | ENCODE | 20.4 | +39.7 | 39725 | 2.1 | HDGF HDAC1 PKNOX1 ARNT NCOA2 TCF12 ATF7 SMARCA5 ZBTB2 ELF1 | C1orf141 MIER1 RNU6-586P GC01M067171 IL23R | |
| GH01I067165 | Promoter/Enhancer | 1.3 | EPDnew ENCODE | 7.8 | +65.1 | 65101 | 2.3 | HDGF PKNOX1 SMAD1 BMI1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 | GC01P067166 IL23R C1orf141 SLC35D1 GC01M067171 | |
| GH01I067018 | Enhancer | 0.8 | Ensembl ENCODE | 10.9 | +212.0 | 212043 | 2.2 | MEIS2 SRF PKNOX1 FOXA2 JUN NR2F2 HIC1 ZNF692 IKZF1 ZNF629 | WDR78 C1orf141 ENSG00000252433 MIER1 SLC35D1 | |
| GH01I067170 | Enhancer | 0.7 | ENCODE | 11.1 | +60.5 | 60525 | 1.8 | BATF IRF4 ZNF766 NFATC1 ATF7 ETV6 IKZF2 RUNX3 SMARCA5 SRF | RNU6-586P C1orf141 ENSG00000252433 GC01M067171 GC01P067166 IL23R |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around C1orf141 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the C1orf141 gene promoter:
Regulatory Element Products
Genomic Locations for C1orf141 Gene
Genomic Locations for C1orf141 Gene
- chr1:67,092,165-67,231,853
- (GRCh38/hg38)
- Size:
- 139,689 bases
- Orientation:
- Minus strand
- chr1:67,557,848-67,697,536
- (GRCh37/hg19)
Genomic View for C1orf141 Gene
Genes around C1orf141 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by Ensembl
- 1p31.3 by Entrez Gene
- 1p31.3 by HGNC
C1orf141 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C1orf141 Gene
Proteins for C1orf141 Gene
-
Protein details for C1orf141 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JVX7-CA141_HUMAN
- Recommended name:
- Uncharacterized protein C1orf141
- Protein Accession:
- Q5JVX7
- Q0P5P5
- Q5JVX5
Protein attributes for C1orf141 Gene
- Size:
- 400 amino acids
- Molecular mass:
- 46135 Da
- Quaternary structure:
- No Data Available
Protein Expression for C1orf141 Gene
Post-translational modifications for C1orf141 Gene
Other Protein References for C1orf141 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C1orf141
- Invitrogen Antibodies for C1orf141
- Search GeneTex for Antibodies for C1orf141
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for C1orf141
- Origene Custom Protein Services for C1orf141
- Search GeneTex for Proteins for C1orf141
Assay Products
No data available for DME Specific Peptides for C1orf141 Gene
Domains & Families for C1orf141 Gene
Gene Families for C1orf141 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf141 Gene
Function for C1orf141 Gene
Phenotypes From GWAS Catalog for C1orf141 Gene
Phenotypes for C1orf141 Gene
- GenomeRNAi human phenotypes for C1orf141:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C1orf141
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C1orf141 gene
- Search ViGene Biosciences for C1orf141
CRISPR Products
-
OriGene CRISPR knockouts for C1orf141
- genomics-online: gRNA clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
- Applied Biological Materials CRISPR for C1orf141
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1orf141
- GenScript: Design CRISPR guide RNA sequences for C1orf141
miRNA Products
- Search ViGene Biosciences for C1orf141
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1orf141
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- genomics-online: shRNA clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
- Search ViGene Biosciences for C1orf141
Clone Products
- VectorBuilder custom plasmid, inducible vectors for C1orf141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C1orf141
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for C1orf141
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for C1orf141
-
ViGene Biosciences adenoviral particle packaged cDNA for C1orf141 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C1orf141 gene
- Search ViGene Biosciences for C1orf141
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf141 Gene
Localization for C1orf141 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C1orf141 Gene
Transcripts for C1orf141 Gene
mRNA/cDNA for C1orf141 Gene
- (12) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (12) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C1orf141 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C1orf141
- genomics-online: gRNA clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
- Applied Biological Materials CRISPR for C1orf141
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1orf141
- GenScript: Design CRISPR guide RNA sequences for C1orf141
miRNA Products
- Search ViGene Biosciences for C1orf141
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1orf141
- Browse OriGene Inhibitory RNA Products For C1orf141
- genomics-online: shRNA clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
- Search ViGene Biosciences for C1orf141
Clone Products
- VectorBuilder custom plasmid, inducible vectors for C1orf141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C1orf141
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for C1orf141
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for C1orf141 Gene
mRNA differential expression in normal tissues according to GTEx for C1orf141 Gene
This gene is overexpressed in Testis (x27.1).
This gene is overexpressed in Brain (62.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf141 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of C1orf141 Gene:
C1orf141SOURCE GeneReport for Unigene cluster for C1orf141 Gene:
Hs.666621Primer Products
-
OriGene qPCR primer pairs for C1orf141
- genomics-online: primer clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf141 Gene
Orthologs for C1orf141 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C1orf141 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | C1orf141 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | C1orf141 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | 4921539E11Rik 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C1orf141 34 |
|
OneToOne |
- Species where no ortholog for C1orf141 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C1orf141 Gene
No data available for Paralogs for C1orf141 Gene
Variants for C1orf141 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000096364 | -- | 67,113,470(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000112841 | -- | 67,131,958(-) | T/A/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000197812 | -- | 67,114,710(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000252111 | -- | 67,108,162(-) | T/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000304300 | -- | 67,107,924(-) | T/C | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.56;
55.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C1orf141 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf141 Gene
Disorders for C1orf141 Gene
Additional Disease Information for C1orf141
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for C1orf141 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf141 Gene
Publications for C1orf141 Gene
- Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PMID: 22019778) Zhang F … Zhang X (Nature genetics 2011) 3 44 58
- Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H … Zhang F (Nature genetics 2015) 3 58
- Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3. (PMID: 25108386) Hou S … Yang P (Nature genetics 2014) 3 58
- Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3 58
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3 58
Products for C1orf141 Gene
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- OriGene qPCR primer pairs for C1orf141
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- Cyagen custom Knockout/knockin (KOKI) mouse models for C1orf141
- VectorBuilder custom plasmid, inducible vectors for C1orf141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C1orf141
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for C1orf141
- Search GeneTex for Proteins for C1orf141
- ViGene Biosciences adenoviral particle packaged cDNA for C1orf141 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C1orf141 gene
- Search ViGene Biosciences for C1orf141
- Horizon Cell Lines for C1orf141
- genomics-online: cdna clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
- orf clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
- genomics-online: gRNA clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
- genomics-online: primer clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
- genomics-online: shRNA clones - Search results for 37 available C1ORF141 gene related products
- Overview of 37 available C1ORF141 gene related products
Sources for C1orf141 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
