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Aliases for C1orf123 Gene

Aliases for C1orf123 Gene

  • Chromosome 1 Open Reading Frame 123 2 3 5
  • UPF0587 Protein C1orf123 3

External Ids for C1orf123 Gene

Previous GeneCards Identifiers for C1orf123 Gene

  • GC01M053392
  • GC01M053452
  • GC01M053679
  • GC01M051795

Summaries for C1orf123 Gene

GeneCards Summary for C1orf123 Gene

C1orf123 (Chromosome 1 Open Reading Frame 123) is a Protein Coding gene.

Additional gene information for C1orf123 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf123 Gene

Genomics for C1orf123 Gene

GeneHancer (GH) Regulatory Elements for C1orf123 Gene

Promoters and enhancers for C1orf123 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J053218 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 682.3 +0.4 393 2.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 POLR2B C1orf123 GC01M053219 PIR31553 ENSG00000259818 PRPF38A TUT4 ENSG00000236723
GH01J053237 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 28.6 -18.0 -17959 2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 MAGOH LOC100507564 C1orf123 NDC1 CYB5RL TUT4 ENSG00000230953 SSBP3-AS1 ENSG00000236723 LINC01771
GH01J053195 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 31.9 +23.4 23392 3.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT SIN3A FEZF1 YY1 POLR2B E2F8 CPT2 C1orf123 MAGOH PIR34935
GH01J052550 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.3 +667.7 667740 5.6 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B CBX5 ZNF207 TUT4 ENSG00000272371 ENSG00000228838 PRPF38A MAGOH ENSG00000266993 CC2D1B RPS13P2 ENSG00000230953 GPX7
GH01J053835 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 -616.5 -616493 4.1 MLX DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D NDC1 MAGOH SSBP3-AS1 HSPB11 LRRC42 ECHDC2 ENSG00000256407 CYB5RL C1orf123 ENSG00000279049
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf123 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf123 gene promoter:
  • HNF-3beta
  • CUTL1
  • FOXO3b
  • FOXO3a
  • FOXO3
  • AML1a
  • AP-2alpha
  • AP-2alphaA

Genomic Locations for C1orf123 Gene

Genomic Locations for C1orf123 Gene
6,541 bases
Minus strand
6,519 bases
Minus strand

Genomic View for C1orf123 Gene

Genes around C1orf123 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf123 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf123 Gene

Proteins for C1orf123 Gene

  • Protein details for C1orf123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0587 protein C1orf123
    Protein Accession:

    Protein attributes for C1orf123 Gene

    160 amino acids
    Molecular mass:
    18048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf123 Gene

Post-translational modifications for C1orf123 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf123 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf123 Gene

Domains & Families for C1orf123 Gene

Gene Families for C1orf123 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf123 Gene


Suggested Antigen Peptide Sequences for C1orf123 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0587 family.
  • Belongs to the UPF0587 family.
genes like me logo Genes that share domains with C1orf123: view

Function for C1orf123 Gene

Gene Ontology (GO) - Molecular Function for C1orf123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C1orf123: view
genes like me logo Genes that share phenotypes with C1orf123: view

Animal Model Products

miRNA for C1orf123 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf123 Gene

Localization for C1orf123 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf123 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1orf123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with C1orf123: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C1orf123 Gene

Pathways & Interactions for C1orf123 Gene

SuperPathways for C1orf123 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C1orf123: view

No data available for Pathways by source and SIGNOR curated interactions for C1orf123 Gene

Drugs & Compounds for C1orf123 Gene

No Compound Related Data Available

Transcripts for C1orf123 Gene

mRNA/cDNA for C1orf123 Gene

Unigene Clusters for C1orf123 Gene

Chromosome 1 open reading frame 123:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf123 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP7: -

Relevant External Links for C1orf123 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf123 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf123 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf123 Gene

Protein tissue co-expression partners for C1orf123 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf123 Gene:


SOURCE GeneReport for Unigene cluster for C1orf123 Gene:


Evidence on tissue expression from TISSUES for C1orf123 Gene

  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with C1orf123: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf123 Gene

Orthologs for C1orf123 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C1orf123 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
C1H1orf123 33
  • 100 (n)
-- 34
  • 99 (a)
(Bos Taurus)
Mammalia C3H1orf123 34 33
  • 91.67 (n)
(Mus musculus)
Mammalia 0610037L13Rik 16 34 33
  • 91.56 (n)
(Canis familiaris)
Mammalia C5H1orf123 33
  • 91.25 (n)
C1orf123 34
  • 75 (a)
(Rattus norvegicus)
Mammalia RGD1559786 33
  • 90.21 (n)
(Ornithorhynchus anatinus)
Mammalia C1orf123 34
  • 83 (a)
(Monodelphis domestica)
Mammalia C1orf123 34
  • 54 (a)
(Gallus gallus)
Aves C1orf123 34
  • 84 (a)
C8H1ORF123 33
  • 79.58 (n)
(Anolis carolinensis)
Reptilia C1orf123 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497300 33
  • 75 (n)
(Danio rerio)
Actinopterygii C2H1orf123 34
  • 82 (a)
si:ch211-284b7.3 33
  • 74.79 (n)
Dr.23495 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10583 33
fruit fly
(Drosophila melanogaster)
Insecta CG4646 34 33
  • 55.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003919 33
  • 54.09 (n)
(Caenorhabditis elegans)
Secernentea F46B6.12 34 33
  • 55.27 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10153g 33
  • 46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL238W 33
  • 43.61 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCR090C 33
  • 43.01 (n)
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32930 33
  • 50.85 (n)
(Oryza sativa)
Liliopsida Os01g0565600 33
  • 52.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08505 33
  • 51.9 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2D10.03c 33
  • 49.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for C1orf123 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C1orf123 Gene

Gene Tree for C1orf123 (if available)
Gene Tree for C1orf123 (if available)

Paralogs for C1orf123 Gene Pseudogenes for C1orf123 Gene

genes like me logo Genes that share paralogs with C1orf123: view

No data available for Paralogs for C1orf123 Gene

Variants for C1orf123 Gene

Sequence variations from dbSNP and Humsavar for C1orf123 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1056438 benign, Carnitine palmitoyltransferase II deficiency 53,214,206(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs14829 likely-benign, Carnitine palmitoyltransferase II deficiency 53,214,202(-) G/A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs886046411 uncertain-significance, Carnitine palmitoyltransferase II deficiency 53,214,195(-) GAAGA/GAAGAAGA 3_prime_UTR_variant, genic_downstream_transcript_variant
rs925274669 uncertain-significance, Carnitine palmitoyltransferase II deficiency 53,214,034(-) T/C downstream_transcript_variant
rs1000367395 -- 53,221,844(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf123 Gene

Variant ID Type Subtype PubMed ID
esv2422213 CNV duplication 17116639
nsv1001535 CNV gain 25217958
nsv829871 CNV loss 17160897

Variation tolerance for C1orf123 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf123 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf123 Gene

Disorders for C1orf123 Gene

Additional Disease Information for C1orf123

No disorders were found for C1orf123 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf123 Gene

Publications for C1orf123 Gene

  1. Cloning, expression, purification, crystallization and X-ray crystallographic analysis of recombinant human C1ORF123 protein. (PMID: 26919524) Rahaman SN … Ng CL (Acta crystallographica. Section F, Structural biology communications 2016) 2 3 58
  2. Integrated genomics and proteomics of the Torpedo californica electric organ: concordance with the mammalian neuromuscular junction. (PMID: 21798097) Mate SE … Hoffman EP (Skeletal muscle 2011) 2 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for C1orf123 Gene

Sources for C1orf123 Gene

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