Aliases for C1orf116 Gene
Aliases for C1orf116 Gene
External Ids for C1orf116 Gene
- HGNC: 28667
- Entrez Gene: 79098
- Ensembl: ENSG00000182795
- OMIM: 611680
- UniProtKB: Q9BW04
Previous GeneCards Identifiers for C1orf116 Gene
- GC01M203581
- GC01M205258
- GC01M207191
- GC01M177889
Summaries for C1orf116 Gene
GeneCards Summary for C1orf116 Gene
C1orf116 (Chromosome 1 Open Reading Frame 116) is a Protein Coding gene.
UniProtKB/Swiss-Prot for C1orf116 Gene
-
Putative androgen-specific receptor.
Additional gene information for C1orf116 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf116 Gene
Genomics for C1orf116 Gene
GeneHancer (GH) Regulatory Elements for C1orf116 Gene
Promoters and enhancers for C1orf116 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around C1orf116 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for C1orf116 Gene
Genomic Locations for C1orf116 Gene
- chr1:207,018,521-207,032,761
- (GRCh38/hg38)
- Size:
- 14,241 bases
- Orientation:
- Minus strand
- chr1:207,191,866-207,206,101
- (GRCh37/hg19)
Genomic View for C1orf116 Gene
Genes around C1orf116 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by Ensembl
- 1q32.1 by Entrez Gene
- 1q32.1 by HGNC
C1orf116 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C1orf116 Gene
Proteins for C1orf116 Gene
-
Protein details for C1orf116 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BW04-SARG_HUMAN
- Recommended name:
- Specifically androgen-regulated gene protein
- Protein Accession:
- Q9BW04
- C9JV41
- Q658X3
Protein attributes for C1orf116 Gene
- Size:
- 601 amino acids
- Molecular mass:
- 63964 Da
- Quaternary structure:
- No Data Available
Protein Expression for C1orf116 Gene
Post-translational modifications for C1orf116 Gene
Other Protein References for C1orf116 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C1orf116
- Novus Biologicals Antibodies for C1orf116
- Invitrogen Antibodies for C1orf116
- GeneTex C1orf116 antibody for C1orf116
Protein Products
-
OriGene Purified Proteins for C1orf116
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- antibodies-online: Search results for 4 available c1orf116 Proteins ranked by validation data
- Compare Top c1orf116 Proteins
-
Quality Products:
- Search GeneTex for Proteins for C1orf116
Assay Products
No data available for DME Specific Peptides for C1orf116 Gene
Domains & Families for C1orf116 Gene
Gene Families for C1orf116 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for C1orf116 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BW04- Family:
-
- Belongs to the SARG family.
Function for C1orf116 Gene
Molecular function for C1orf116 Gene
- UniProtKB/Swiss-Prot Function:
- Putative androgen-specific receptor.
- UniProtKB/Swiss-Prot Induction:
- Expression is up-regulated by androgen, but not by glucocorticoids.
Phenotypes From GWAS Catalog for C1orf116 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | 19447967 |
Phenotypes for C1orf116 Gene
- GenomeRNAi human phenotypes for C1orf116:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1orf116
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miRNA for C1orf116 Gene
- miRTarBase miRNAs that target C1orf116
miRNA Products
- Search ViGene Biosciences for C1orf116
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1orf116
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available c1orf116 gene related products
- orf clones - Search results for available c1orf116 gene related products
- Applied Biological Materials Clones for C1orf116
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for C1orf116
-
ViGene Biosciences adenoviral particle packaged cDNA for C1orf116 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C1orf116 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C1orf116 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf116 Gene
Localization for C1orf116 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C1orf116 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
- Cytosol (3)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 15525603 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0070062 | extracellular exosome | IDA,HDA | 19056867 |
Pathways & Interactions for C1orf116 Gene
No Data Available
Interacting Proteins for C1orf116 Gene
Selected Interacting proteins:
Q9BW04-SARG_HUMAN
ENSP00000352447
for C1orf116 Gene via
UniProtKB
IID
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for C1orf116 Gene
Transcripts for C1orf116 Gene
mRNA/cDNA for C1orf116 Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (135) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C1orf116 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C1orf116
- genomics-online: gRNA clones - Search results for available c1orf116 gene related products
- Applied Biological Materials CRISPR for C1orf116
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1orf116
- GenScript: Design CRISPR guide RNA sequences for C1orf116
miRNA Products
- Search ViGene Biosciences for C1orf116
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1orf116
- Browse OriGene Inhibitory RNA Products For C1orf116
- genomics-online: shRNA clones - Search results for available c1orf116 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for C1orf116 gene
Clone Products
- Sino Biological Human cDNA Clone for C1orf116
- VectorBuilder custom plasmid, inducible vectors for C1orf116
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C1orf116
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available c1orf116 gene related products
- orf clones - Search results for available c1orf116 gene related products
- Applied Biological Materials Clones for C1orf116
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||
| SP6: |
Expression for C1orf116 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for C1orf116 Gene
This gene is overexpressed in Esophagus - Mucosa (x13.8), Lung (x5.4), Skin - Sun Exposed (Lower leg) (x5.0), Stomach (x4.7), Minor Salivary Gland (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.3).
This gene is overexpressed in Cervix (38.4) and Lavage (11.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf116 Gene
NURSA nuclear receptor signaling pathways regulating expression of C1orf116 Gene:
C1orf116SOURCE GeneReport for Unigene cluster for C1orf116 Gene:
Hs.32417mRNA Expression by UniProt/SwissProt for C1orf116 Gene:
Q9BW04-SARG_HUMAN
Tissue specificity:
Highly expressed in prostate.
Evidence on tissue expression from TISSUES for C1orf116 Gene
- Lung(4.6)
- Stomach(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for C1orf116
-
OriGene qPCR primer pairs for C1orf116
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Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf116 Gene
Orthologs for C1orf116 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C1H1orf116 33 |
|
||
| C1orf116 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C16H1orf116 33 |
|
||
| SARG 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | AA986860 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC498222 33 |
|
||
| dog (Canis familiaris) |
Mammalia | C1orf116 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C1orf116 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C1orf116 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C1ORF116 33 |
|
||
| C1orf116 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | C1orf116 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | c1orf116 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | C23H1orf116 (2 of 2) 34 |
|
OneToMany | |
| C11H1orf116 (1 of 2) 34 |
|
OneToMany |
- Species where no ortholog for C1orf116 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C1orf116 Gene
No data available for Paralogs for C1orf116 Gene
Variants for C1orf116 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000029117 | -- | 207,028,869(-) | T/C | intron_variant | |
| rs1000776646 | -- | 207,022,065(-) | C/A | coding_sequence_variant, missense_variant | |
| rs1001413815 | -- | 207,025,171(-) | C/T | intron_variant | |
| rs1001538025 | -- | 207,026,206(-) | A/T | intron_variant | |
| rs1001616031 | -- | 207,030,762(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1010486 | CNV | gain | 25217958 |
| nsv832426 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.99;
74.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C1orf116 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C1orf116
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf116 Gene
Disorders for C1orf116 Gene
Additional Disease Information for C1orf116
No disorders were found for C1orf116 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf116 Gene
Publications for C1orf116 Gene
- A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in the first intron. (PMID: 15525603) Steketee K … Trapman J (Journal of molecular endocrinology 2004) 2 3 4 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Both androgen receptor and glucocorticoid receptor are able to induce prostate-specific antigen expression, but differ in their growth-stimulating properties of LNCaP cells. (PMID: 9389513) Cleutjens CB … Trapman J (Endocrinology 1997) 2 3 58
- Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration. (PMID: 28651527) Parsana P … Battle A (BMC cancer 2017) 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
Products for C1orf116 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for C1orf116
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 15 available c1orf116 Antibodies ranked by validation data
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- antibodies-online: Search results for available c1orf116 related products ranked by validation data
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- Quality Products:
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Sources for C1orf116 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems