C1orf116 Gene (Protein Coding)

Chromosome 1 Open Reading Frame 116

GC01M207018
GIFtS:
34

Aliases for C1orf116 Gene

Aliases for C1orf116 Gene

  • Chromosome 1 Open Reading Frame 116 2 3 5
  • Specifically Androgen-Regulated Gene Protein 3 4
  • Specifically Androgen-Regulated Protein 3
  • Specifically Androgen-Regulated Gene 2
  • SARG 3

External Ids for C1orf116 Gene

Previous GeneCards Identifiers for C1orf116 Gene

  • GC01M203581
  • GC01M205258
  • GC01M207191
  • GC01M177889

Summaries for C1orf116 Gene

GeneCards Summary for C1orf116 Gene

C1orf116 (Chromosome 1 Open Reading Frame 116) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for C1orf116 Gene

Additional gene information for C1orf116 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf116 Gene

Genomics for C1orf116 Gene

GeneHancer (GH) Regulatory Elements for C1orf116 Gene

Promoters and enhancers for C1orf116 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J207017 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 756.4 +6.1 6093 18.4 SIN3A ZBTB40 ZBTB6 FOXA1 RBPJ SMARCE1 POLR2A TCF7L2 NR2F6 CREB1 C1orf116 EIF2D CDCA4P4 C4BPA CD46 CD34 C4BPB FCAMR PIGR FCMR
GH01J207048 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -20.2 -20182 9.7 GTF3C2 ZBTB40 CTCF SREBF1 ZBTB6 RBPJ SMARCE1 POLR2A USF2 ATF1 PFKFB2 YOD1 EIF2D CDCA4P4 MAPKAPK2 ENSG00000234981 CD46 C1orf116 CR1 CD55
GH01J206734 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +294.9 294860 7.4 ZNF24 SP1 CTCF SMARCE1 NR2F6 RUNX1 CC2D1A ETV6 ELF1 MAX IL24 MAPKAPK2 FCMR IL19 IL10 PIGR IL20 C1orf116 DYRK3 CD55
GH01J206907 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 9.5 +123.5 123514 2.5 POLR2A L3MBTL2 NFIB SP7 PRDM1 GLIS2 PKNOX1 ZIC2 GTF2E2 REST ENSG00000226945 RPL13AP8 piR-46238-001 ENSG00000271680 PIGR IL20 FCAMR IL19 MAPKAPK2 C1orf116
GH01J206966 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 9.7 +61.9 61903 7.9 USF2 ETV6 RELA HLF SP1 MAFK ZNF687 ZBTB33 IKZF1 RXRA FCAMR lnc-PIGR-4 PIGR FCMR IL20 IL24 IL10 MAPKAPK2 IL19 ENSG00000271680
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf116 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf116 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HSF2
  • HTF
  • Msx-1
  • STAT5A

Genomic Locations for C1orf116 Gene

Genomic Locations for C1orf116 Gene
chr1:207,018,521-207,032,761
(GRCh38/hg38)
Size:
14,241 bases
Orientation:
Minus strand
chr1:207,191,866-207,206,101
(GRCh37/hg19)
Size:
14,236 bases
Orientation:
Minus strand

Genomic View for C1orf116 Gene

Genes around C1orf116 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf116 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf116 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C1orf116 Gene

Proteins for C1orf116 Gene

Products:

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  • Protein details for C1orf116 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW04-SARG_HUMAN
    Recommended name:
    Specifically androgen-regulated gene protein
    Protein Accession:
    Q9BW04
    Secondary Accessions:
    • C9JV41
    • Q658X3

    Protein attributes for C1orf116 Gene

    Size:
    601 amino acids
    Molecular mass:
    63964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf116 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf116 Gene

Protein Expression for C1orf116 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for C1orf116 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf116 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf116 Gene

Domains & Families for C1orf116 Gene

Gene Families for C1orf116 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf116 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf116 Gene

GenScript: Design optimal peptide antigens:
  • C1orf116 protein (Q9BPY1_HUMAN)
  • Specifically androgen-regulated gene protein (SARG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BW04

UniProtKB/Swiss-Prot:

SARG_HUMAN :
  • Belongs to the SARG family.
Family:
  • Belongs to the SARG family.
genes like me logo Genes that share domains with C1orf116: view

Function for C1orf116 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for C1orf116 Gene

UniProtKB/Swiss-Prot Function:
Putative androgen-specific receptor.
UniProtKB/Swiss-Prot Induction:
Expression is up-regulated by androgen, but not by glucocorticoids.

Phenotypes From GWAS Catalog for C1orf116 Gene

Gene Ontology (GO) - Molecular Function for C1orf116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19447967
genes like me logo Genes that share ontologies with C1orf116: view
genes like me logo Genes that share phenotypes with C1orf116: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf116

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf116 Gene

Localization for C1orf116 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf116 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf116 gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 15525603
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with C1orf116: view

Pathways & Interactions for C1orf116 Gene

PathCards logo

SuperPathways for C1orf116 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C1orf116: view

No data available for Pathways by source and SIGNOR curated interactions for C1orf116 Gene

Drugs & Compounds for C1orf116 Gene

Products:

  1. Drug

(1) Drugs for C1orf116 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with C1orf116: view

Transcripts for C1orf116 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for C1orf116 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf116

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf116 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: - - - -
SP6:

Relevant External Links for C1orf116 Gene

GeneLoc Exon Structure for
C1orf116
ECgene alternative splicing isoforms for
C1orf116

Expression for C1orf116 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf116 Gene

mRNA expression in normal human tissues for C1orf116 Gene
mRNA expression by GTEx for C1orf116 GenemRNA expression by BioGPS for C1orf116 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf116 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.8), Lung (x5.4), Skin - Sun Exposed (Lower leg) (x5.0), Stomach (x4.7), Minor Salivary Gland (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Protein differential expression in normal tissues from HIPED for C1orf116 Gene

This gene is overexpressed in Cervix (38.4) and Lavage (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf116 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1orf116 Gene:

C1orf116

SOURCE GeneReport for Unigene cluster for C1orf116 Gene:

Hs.32417

mRNA Expression by UniProt/SwissProt for C1orf116 Gene:

Q9BW04-SARG_HUMAN
Tissue specificity: Highly expressed in prostate.

Evidence on tissue expression from TISSUES for C1orf116 Gene

  • Lung(4.6)
  • Stomach(4.3)
genes like me logo Genes that share expression patterns with C1orf116: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf116 Gene

Orthologs for C1orf116 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf116 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia C1H1orf116 32
  • 98.89 (n)
C1orf116 33
  • 97 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia C16H1orf116 32
  • 77.29 (n)
SARG 33
  • 70 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia AA986860 17 33 32
  • 73.27 (n)
rat
(Rattus norvegicus)
 Mammalia LOC498222 32
  • 72.7 (n)
dog
(Canis familiaris)
 Mammalia C1orf116 33
  • 54 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia C1orf116 33
  • 53 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia C1orf116 33
  • 48 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves C1ORF116 32
  • 55.42 (n)
C1orf116 33
  • 38 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia C1orf116 33
  • 36 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia c1orf116 32
  • 49.02 (n)
zebrafish
(Danio rerio)
 Actinopterygii C23H1orf116 (2 of 2) 33
  • 33 (a)
 OneToMany
C11H1orf116 (1 of 2) 33
  • 24 (a)
 OneToMany
Species where no ortholog for C1orf116 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf116 Gene

ENSEMBL:
Gene Tree for C1orf116 (if available)
TreeFam:
Gene Tree for C1orf116 (if available)

Paralogs for C1orf116 Gene

No data available for Paralogs for C1orf116 Gene

Variants for C1orf116 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for C1orf116 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000029117 -- 207,028,869(-) T/C intron_variant
rs1000776646 -- 207,022,065(-) C/A coding_sequence_variant, missense_variant
rs1001413815 -- 207,025,171(-) C/T intron_variant
rs1001538025 -- 207,026,206(-) A/T intron_variant
rs1001616031 -- 207,030,762(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf116 Gene

Variant ID Type Subtype PubMed ID
nsv1010486 CNV gain 25217958
nsv832426 CNV gain 17160897

Variation tolerance for C1orf116 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf116 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf116

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf116 Gene

Disorders for C1orf116 Gene

Additional Disease Information for C1orf116

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C1orf116 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf116 Gene

Publications for C1orf116 Gene

  1. A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in the first intron. (PMID: 15525603) Steketee K … Trapman J (Journal of molecular endocrinology 2004) 2 3 4 23 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Both androgen receptor and glucocorticoid receptor are able to induce prostate-specific antigen expression, but differ in their growth-stimulating properties of LNCaP cells. (PMID: 9389513) Cleutjens CB … Trapman J (Endocrinology 1997) 2 3 56
  4. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3 56
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 56

ExternalLinks

View latest publications for C1orf116 gene in Mastermind

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