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Aliases for C1orf116 Gene
Aliases for C1orf116 Gene
External Ids for C1orf116 Gene
- HGNC: 28667
- Entrez Gene: 79098
- Ensembl: ENSG00000182795
- OMIM: 611680
- UniProtKB: Q9BW04
Previous GeneCards Identifiers for C1orf116 Gene
- GC01M203581
- GC01M205258
- GC01M207191
- GC01M177889
Summaries for C1orf116 Gene
GeneCards Summary for C1orf116 Gene
C1orf116 (Chromosome 1 Open Reading Frame 116) is a Protein Coding gene. Diseases associated with C1orf116 include Overhydrated Hereditary Stomatocytosis and Lymph Node Carcinoma.
UniProtKB/Swiss-Prot Summary for C1orf116 Gene
-
Putative androgen-specific receptor.
Additional gene information for C1orf116 Gene
- HGNC(28667)
- Entrez Gene(79098)
- Ensembl(ENSG00000182795)
- OMIM(611680)
- UniProtKB(Q9BW04)
- Open Targets Platform(ENSG00000182795)
- Search for C1orf116 at DataMed
- Search for C1orf116 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf116 Gene
Genomics for C1orf116 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for C1orf116 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around C1orf116 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf116
- Top Transcription factor binding sites by QIAGEN in the C1orf116 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- HSF2
- HTF
- Msx-1
- STAT5A
Genomic Locations for C1orf116 Gene
Genomic Locations for C1orf116 Gene
- chr1:207,018,521-207,032,761
- (GRCh38/hg38)
- Size:
- 14,241 bases
- Orientation:
- Minus strand
- chr1:207,191,866-207,206,101
- (GRCh37/hg19)
- Size:
- 14,236 bases
- Orientation:
- Minus strand
Genomic View for C1orf116 Gene
Genes around C1orf116 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by HGNC
- 1q32.1 by Entrez Gene
- 1q32.1 by Ensembl
C1orf116 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C1orf116 Gene
Proteins for C1orf116 Gene
-
Protein details for C1orf116 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BW04-SARG_HUMAN
- Recommended name:
- Specifically androgen-regulated gene protein
- Protein Accession:
- Q9BW04
- C9JV41
- Q658X3
Protein attributes for C1orf116 Gene
- Size:
- 601 amino acids
- Molecular mass:
- 63964 Da
- Quaternary structure:
- No Data Available
Protein Expression for C1orf116 Gene
Post-translational modifications for C1orf116 Gene
Other Protein References for C1orf116 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-C1ORF116 polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for C1orf116
- Novus Biologicals Antibodies for C1orf116
- Invitrogen Antibodies for C1orf116 (AFLGC-C1orf116)
- Sino Biological Antibodies for C1orf116
Protein Products
-
OriGene Purified Proteins for C1orf116
- Search Origene for MassSpec and Protein Over-expression Lysates for C1orf116
- Origene Custom Protein Services for C1orf116
- antibodies-online: Show 4 available c1orf116 Proteins ranked by validation data
- Compare Top c1orf116 Proteins
-
Quality Products:
No data available for DME Specific Peptides for C1orf116 Gene
Domains & Families for C1orf116 Gene
Gene Families for C1orf116 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for C1orf116 Gene
- GenScript: Design optimal peptide antigens:
-
- C1orf116 protein (Q9BPY1_HUMAN)
- Specifically androgen-regulated gene protein (SARG_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BW04- Family:
-
- Belongs to the SARG family.
Function for C1orf116 Gene
Molecular function for C1orf116 Gene
- UniProtKB/Swiss-Prot Function:
- Putative androgen-specific receptor.
- UniProtKB/Swiss-Prot Induction:
- Expression is up-regulated by androgen, but not by glucocorticoids.
Phenotypes From GWAS Catalog for C1orf116 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | 19447967 |
Phenotypes for C1orf116 Gene
- GenomeRNAi human phenotypes for C1orf116:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C1orf116 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for C1orf116
miRNA for C1orf116 Gene
- miRTarBase miRNAs that target C1orf116
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1orf116
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Clone Products
- Applied Biological Materials (abm): Clones for C1orf116 - Select products 50% OFF >
- * C1orf116 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for C1orf116
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C1orf116
Cell Line Products
-
Horizon Cell Lines for C1orf116
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf116 Gene
Localization for C1orf116 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C1orf116 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| cytosol | 4 |
| nucleus | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 15525603 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for C1orf116 Gene
Interacting Proteins for C1orf116 Gene
Selected Interacting proteins:
Q9BW04-SARG_HUMAN
ENSP00000352447
for C1orf116 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for C1orf116
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for C1orf116 Gene
Transcripts for C1orf116 Gene
mRNA/cDNA for C1orf116 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000359470 5501 nts (view in UCSC)
- ENST00000461135 3142 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C1orf116 - Select products 50% OFF >
- * C1orf116 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for C1orf116
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C1orf116
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1orf116
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1orf116
- Browse OriGene Inhibitory RNA Products For C1orf116
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf116
Clone Products
- Applied Biological Materials (abm): Clones for C1orf116 - Select products 50% OFF >
- * C1orf116 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for C1orf116
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C1orf116
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||
| SP6: |
Relevant External Links for C1orf116 Gene
- GeneLoc Exon Structure for
- C1orf116
Expression for C1orf116 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for C1orf116 Gene
This gene is overexpressed in Esophagus - Mucosa (x13.8), Lung (x5.4), Skin - Sun Exposed (Lower leg) (x5.0), Stomach (x4.7), Minor Salivary Gland (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.3).
This gene is overexpressed in Cervix (38.4) and Lavage (11.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf116 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf116
SOURCE GeneReport for Unigene cluster for C1orf116 Gene:
Hs.32417mRNA Expression by UniProt/SwissProt for C1orf116 Gene:
Q9BW04-SARG_HUMAN
Tissue specificity:
Highly expressed in prostate.
Evidence on tissue expression from TISSUES for C1orf116 Gene
- Lung(4.6)
- Stomach(4.3)
- Skin(2.4)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for C1orf116
-
OriGene qPCR primer pairs and template standards for C1orf116
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf116 Gene
Orthologs for C1orf116 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C1H1orf116 30 |
|
||
| C1orf116 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | C16H1orf116 30 |
|
||
| SARG 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | AA986860 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC498222 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | C1orf116 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | C1orf116 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | C1orf116 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | C1ORF116 30 |
|
||
| C1orf116 31 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | C1orf116 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | c1orf116 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | C23H1orf116 (2 of 2) 31 |
|
OneToMany | |
| C11H1orf116 (1 of 2) 31 |
|
OneToMany |
- Species where no ortholog for C1orf116 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for C1orf116 Gene
No data available for Paralogs for C1orf116 Gene
Variants for C1orf116 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf116 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11799966 | - | p.Phe514Ser | |||
| rs12062114 | - | p.Arg258Gly | |||
| rs2842726 | - | p.Ser444Pro | |||
| rs34660159 | - | p.Asn157Thr | |||
| rs35267170 | - | p.Asn434Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1010486 | CNV | gain | 25217958 |
| nsv832426 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.99;
74.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C1orf116 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C1orf116
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf116 Gene
Disorders for C1orf116 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| overhydrated hereditary stomatocytosis |
|
|
| lymph node carcinoma |
|
|
| fibrosarcomatous osteosarcoma |
|
|
Search C1orf116 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for C1orf116
No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf116 Gene
Publications for C1orf116 Gene
- A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in the first intron. (PMID: 15525603) Steketee K … Trapman J (Journal of molecular endocrinology 2004) 2 3 4 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Both androgen receptor and glucocorticoid receptor are able to induce prostate-specific antigen expression, but differ in their growth-stimulating properties of LNCaP cells. (PMID: 9389513) Cleutjens CB … Trapman J (Endocrinology 1997) 2 3
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3
ExternalLinks
Products for C1orf116 Gene
- Custom Antibody ServicesOriGene Antibodies for C1orf116
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- Custom Assay Services
- OriGene Purified Proteins for C1orf116
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- Origene Custom Protein Services for C1orf116
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- Browse OriGene Inhibitory RNA Products For C1orf116
- OriGene qPCR primer pairs for C1orf116
- OriGene qPCR primer pairs and template standards for C1orf116
- OriGene CRISPR knockouts for C1orf116
- OriGene ORF clones in human for C1orf116
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals proteins and lysates for C1orf116
- Browse Antibodies
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- Browse ELISA Kits
- Invitrogen Antibodies for C1orf116 (AFLGC-C1orf116)
- VectorBuilder Custom and pre-made DNA vectors for C1orf116 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for C1orf116 (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 3 available c1orf116 Antibodies ranked by validation data
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- antibodies-online: Search results for available c1orf116 related products ranked by validation data
- antibodies-online: Show 4 available c1orf116 Proteins ranked by validation data
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- Quality Products:
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf116
Sources for C1orf116 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB