Aliases for C1orf115 Gene

Aliases for C1orf115 Gene

  • Chromosome 1 Open Reading Frame 115 2 3 5
  • Required For Drug-Induced Death 1 2 3
  • Uncharacterized Protein C1orf115 3 4
  • RDD1 2 3
  • C1orf115 5
  • FLJ14146 2

External Ids for C1orf115 Gene

Previous GeneCards Identifiers for C1orf115 Gene

  • GC01P217252
  • GC01P218929
  • GC01P220863
  • GC01P191538

Summaries for C1orf115 Gene

GeneCards Summary for C1orf115 Gene

C1orf115 (Chromosome 1 Open Reading Frame 115) is a Protein Coding gene.

Additional gene information for C1orf115 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf115 Gene

Genomics for C1orf115 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1orf115 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J220689 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 272 +0.7 738 3 ZBTB10 CEBPA ZNF217 CTCF ZBTB7B ZEB1 ZIC2 ZNF610 TRIM22 SMAD4 C1orf115 MTARC1 HSALNG0010747 MTARC2
GH01J220732 Enhancer 0.9 ENCODE 32.2 +43.4 43389 3 CEBPA FOXA1 CTCF ELF1 KDM6A THAP11 CEBPB ELK1 GABPA REST HSALNG0010749 C1orf115 MTARC1 lnc-RAB3GAP2-8 MTARC2
GH01J220711 Enhancer 0.9 Ensembl ENCODE 31 +20.5 20538 2.6 IRF4 SMAD4 SAP130 MIER3 ETV4 RARA TEAD3 FOXA2 BCL6 FOXP1 C1orf115 MTARC2 HLX-AS1 HSALNG0010747 lnc-RAB3GAP2-8
GH01J220746 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 +59.0 59008 5.2 ZBTB10 MXD4 CEBPA ZNF610 CEBPB MAX SMAD4 SAP130 ZNF341 POLR2A HSALNG0010752 MTARC2 RF00017-482 C1orf115 MTARC1
GH01J220766 Enhancer 0.9 ENCODE 22.4 +77.7 77697 3.5 CEBPA ZIC2 KDM6A FOXA2 ZNF511 MAFF SMAD4 SAP130 TAL1 RXRA NONHSAG004355.2 C1orf115 MTARC1 MTARC2 HSALNG0010754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf115 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf115

Top Transcription factor binding sites by QIAGEN in the C1orf115 gene promoter:
  • AhR
  • Arnt
  • CUTL1
  • E47
  • FOXC1
  • GATA-3
  • Pax-5
  • SRF
  • SRF (504 AA)

Genomic Locations for C1orf115 Gene

Latest Assembly
chr1:220,690,363-220,699,153
(GRCh38/hg38)
Size:
8,791 bases
Orientation:
Plus strand

Previous Assembly
chr1:220,863,705-220,872,495
(GRCh37/hg19 by Entrez Gene)
Size:
8,791 bases
Orientation:
Plus strand

chr1:220,863,187-220,872,499
(GRCh37/hg19 by Ensembl)
Size:
9,313 bases
Orientation:
Plus strand

Genomic View for C1orf115 Gene

Genes around C1orf115 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf115 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf115 Gene

Proteins for C1orf115 Gene

  • Protein details for C1orf115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7X2-CA115_HUMAN
    Recommended name:
    Uncharacterized protein C1orf115
    Protein Accession:
    Q9H7X2
    Secondary Accessions:
    • B3KRN3
    • D3DTB2

    Protein attributes for C1orf115 Gene

    Size:
    142 amino acids
    Molecular mass:
    15517 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf115 Gene

Post-translational modifications for C1orf115 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf115 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf115 Gene

Domains & Families for C1orf115 Gene

Gene Families for C1orf115 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf115 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C1orf115: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1orf115 Gene

Function for C1orf115 Gene

Phenotypes From GWAS Catalog for C1orf115 Gene

genes like me logo Genes that share phenotypes with C1orf115: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf115

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf115 Gene

Localization for C1orf115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf115 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf115 gene
Compartment Confidence
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C1orf115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0097731 9+0 non-motile cilium IDA 29257953
genes like me logo Genes that share ontologies with C1orf115: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1orf115 Gene

Pathways & Interactions for C1orf115 Gene

PathCards logo

SuperPathways for C1orf115 Gene

No Data Available

Interacting Proteins for C1orf115 Gene

Selected Interacting proteins: Q9H7X2-CA115_HUMAN for C1orf115 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for C1orf115 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf115 Gene

Drugs & Compounds for C1orf115 Gene

No Compound Related Data Available

Transcripts for C1orf115 Gene

mRNA/cDNA for C1orf115 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf115

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf115 Gene

No ASD Table

Relevant External Links for C1orf115 Gene

GeneLoc Exon Structure for
C1orf115

Expression for C1orf115 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf115 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf115 Gene

This gene is overexpressed in Brain - Cortex (x4.3), Brain - Frontal Cortex (BA9) (x4.2), and Liver (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf115

SOURCE GeneReport for Unigene cluster for C1orf115 Gene:

Hs.519839

Evidence on tissue expression from TISSUES for C1orf115 Gene

  • Nervous system(4.7)
  • Kidney(4.4)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with C1orf115: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf115 Gene

Orthologs for C1orf115 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf115 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C1H1orf115 30
  • 99.06 (n)
C1orf115 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C1orf115 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C16H1orf115 30 31
  • 86.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1310587 30
  • 77.38 (n)
Mouse
(Mus musculus)
Mammalia C130074G19Rik 30 17 31
  • 76.83 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C1orf115 31
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C1orf115 31
  • 51 (a)
OneToOne
Species where no ortholog for C1orf115 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C1orf115 Gene

ENSEMBL:
Gene Tree for C1orf115 (if available)
TreeFam:
Gene Tree for C1orf115 (if available)

Paralogs for C1orf115 Gene

No data available for Paralogs for C1orf115 Gene

Variants for C1orf115 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C1orf115 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C1orf115 Gene

Variant ID Type Subtype PubMed ID
nsv468194 CNV loss 19166990
nsv549227 CNV loss 21841781
nsv826742 CNV loss 20364138
nsv945303 CNV duplication 23825009

Variation tolerance for C1orf115 Gene

Gene Damage Index Score: 1.02; 20.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf115 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf115

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf115 Gene

Disorders for C1orf115 Gene

Additional Disease Information for C1orf115

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for C1orf115 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf115 Gene

Publications for C1orf115 Gene

  1. Systematic functional identification of cancer multi-drug resistance genes. (PMID: 32028983) Lau MT … Neely GG (Genome biology 2020) 2 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3

Products for C1orf115 Gene

Sources for C1orf115 Gene