Aliases for C1orf109 Gene

Aliases for C1orf109 Gene

  • Chromosome 1 Open Reading Frame 109 2 3 5
  • Uncharacterized Protein C1orf109 3 4

External Ids for C1orf109 Gene

Previous GeneCards Identifiers for C1orf109 Gene

  • GC01M037817
  • GC01M037919
  • GC01M038147
  • GC01M036264

Summaries for C1orf109 Gene

GeneCards Summary for C1orf109 Gene

C1orf109 (Chromosome 1 Open Reading Frame 109) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for C1orf109 Gene

  • May promote cancer cell proliferation by controlling the G1 to S phase transition.

Additional gene information for C1orf109 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf109 Gene

Genomics for C1orf109 Gene

GeneHancer (GH) Regulatory Elements for C1orf109 Gene

Promoters and enhancers for C1orf109 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J037688 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 789.4 +0.9 892 5.5 ZBTB40 SP1 CTCF SIX5 FOXA1 ZBTB6 SMARCE1 RBPJ POLR2A USF2 C1orf109 CDCA8 lnc-C1orf109-1 SF3A3 GNL2 ZC3H12A FTH1P1 EPHA10 LINC01137 INPP5B
GH01J037988 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 83.3 -297.4 -297358 2.6 FOXK2 E2F8 ZNF785 SIN3A SP1 ZBTB40 CTCF SIX5 ZBTB6 MLX SF3A3 RNU6-510P RF00026-026 C1orf109 MYCBP FTH1P1 GNL2 ZC3H12A INPP5B FHL3
GH01J038008 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 77.5 -320.6 -320574 9.3 ZNF785 ZBTB40 SP1 SIX5 MLX SMARCE1 RBPJ POLR2A USF2 HDAC2 UTP11 SF3A3 SNIP1 C1orf109 INPP5B GNL2 FTH1P1 ZC3H12A MYCBP RSPO1
GH01J037552 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 61.7 +138.4 138435 2.2 E2F8 ZNF785 SIN3A SP1 ZBTB40 SREBF1 SIX5 RBPJ POLR2A MCM5 SNIP1 lnc-GNL2-2 SF3A3 GNL2 C1orf109 FTH1P1 CDCA8 INPP5B ZC3H12A YRDC
GH01J037858 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.6 -167.4 -167443 3.6 SIN3A SP1 ZBTB40 CTCF SMARCE1 RBPJ POLR2A USF2 ATF1 FOS ENSG00000230955 MTF1 SF3A3 SNIP1 GNL2 C1orf109 ZC3H12A FTH1P1 INPP5B UTP11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf109 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf109 gene promoter:
  • AML1a
  • AREB6
  • Nkx2-2
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)

Genomic Locations for C1orf109 Gene

Genomic Locations for C1orf109 Gene
chr1:37,681,570-37,692,336
(GRCh38/hg38)
Size:
10,767 bases
Orientation:
Minus strand
chr1:38,147,242-38,157,914
(GRCh37/hg19)
Size:
10,673 bases
Orientation:
Minus strand

Genomic View for C1orf109 Gene

Genes around C1orf109 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf109 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf109 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf109 Gene

Proteins for C1orf109 Gene

  • Protein details for C1orf109 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX04-CA109_HUMAN
    Recommended name:
    Uncharacterized protein C1orf109
    Protein Accession:
    Q9NX04
    Secondary Accessions:
    • D3DPT1
    • Q8WVD1

    Protein attributes for C1orf109 Gene

    Size:
    203 amino acids
    Molecular mass:
    23373 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf109 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf109 Gene

Post-translational modifications for C1orf109 Gene

No data available for DME Specific Peptides for C1orf109 Gene

Domains & Families for C1orf109 Gene

Gene Families for C1orf109 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf109 Gene

genes like me logo Genes that share domains with C1orf109: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1orf109 Gene

Function for C1orf109 Gene

Molecular function for C1orf109 Gene

UniProtKB/Swiss-Prot Function:
May promote cancer cell proliferation by controlling the G1 to S phase transition.

Phenotypes From GWAS Catalog for C1orf109 Gene

Gene Ontology (GO) - Molecular Function for C1orf109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with C1orf109: view
genes like me logo Genes that share phenotypes with C1orf109: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf109 Gene

Localization for C1orf109 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf109 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf109 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22548824
GO:0005737 cytoplasm IDA,IEA 22548824
genes like me logo Genes that share ontologies with C1orf109: view

Pathways & Interactions for C1orf109 Gene

PathCards logo

SuperPathways for C1orf109 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf109 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf109 Gene

Drugs & Compounds for C1orf109 Gene

No Compound Related Data Available

Transcripts for C1orf109 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf109 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - -
SP13: - -
SP14: -
SP15:
SP16: - -
SP17: -

ExUns: 8c ^ 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for C1orf109 Gene

GeneLoc Exon Structure for
C1orf109
ECgene alternative splicing isoforms for
C1orf109

Expression for C1orf109 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf109 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1orf109 Gene

This gene is overexpressed in Fetal ovary (24.5) and Plasma (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf109 Gene



Protein tissue co-expression partners for C1orf109 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf109 Gene:

C1orf109

SOURCE GeneReport for Unigene cluster for C1orf109 Gene:

Hs.272673

Evidence on tissue expression from TISSUES for C1orf109 Gene

  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with C1orf109: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf109 Gene

Orthologs for C1orf109 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf109 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf109 33
  • 99 (a)
OneToOne
C1H1orf109 32
  • 98.85 (n)
cow
(Bos Taurus)
Mammalia C3H1orf109 32
  • 87.85 (n)
MGC166151 33
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C15H1orf109 32
  • 83.42 (n)
C1orf109 33
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9930104L06Rik 17 32
  • 80.95 (n)
rat
(Rattus norvegicus)
Mammalia RGD1560436 32
  • 80.62 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf109 33
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf109 33
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF109 32
  • 54.02 (n)
C1orf109 33
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf109 33
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf109 32
  • 55.72 (n)
zebrafish
(Danio rerio)
Actinopterygii c1orf109 32
  • 49.74 (n)
C19H1orf109 33
  • 37 (a)
OneToOne
Species where no ortholog for C1orf109 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf109 Gene

ENSEMBL:
Gene Tree for C1orf109 (if available)
TreeFam:
Gene Tree for C1orf109 (if available)

Paralogs for C1orf109 Gene

No data available for Paralogs for C1orf109 Gene

Variants for C1orf109 Gene

Sequence variations from dbSNP and Humsavar for C1orf109 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000159373 -- 37,687,826(-) G/C intron_variant
rs1000316293 -- 37,688,188(-) C/T intron_variant
rs1000468782 -- 37,691,486(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000496392 -- 37,686,764(-) G/A intron_variant
rs1000823175 -- 37,691,036(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf109 Gene

Variant ID Type Subtype PubMed ID
nsv819737 CNV loss 19587683
nsv834746 CNV loss 17160897

Variation tolerance for C1orf109 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf109 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf109

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf109 Gene

Disorders for C1orf109 Gene

Additional Disease Information for C1orf109

No disorders were found for C1orf109 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf109 Gene

Publications for C1orf109 Gene

  1. Identification and characterization of a novel gene, c1orf109, encoding a CK2 substrate that is involved in cancer cell proliferation. (PMID: 22548824) Liu SS … Li Y (Journal of biomedical science 2012) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. (PMID: 30232004) Abraham CG … Espinosa JM (Cell reports 2018) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for C1orf109 Gene

Sources for C1orf109 Gene