Aliases for C1orf109 Gene

Aliases for C1orf109 Gene

  • Chromosome 1 Open Reading Frame 109 2 3 5
  • Uncharacterized Protein C1orf109 3 4
  • C1orf109 5
  • FLJ20508 2

External Ids for C1orf109 Gene

Previous GeneCards Identifiers for C1orf109 Gene

  • GC01M037817
  • GC01M037919
  • GC01M038147
  • GC01M036264

Summaries for C1orf109 Gene

GeneCards Summary for C1orf109 Gene

C1orf109 (Chromosome 1 Open Reading Frame 109) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for C1orf109 Gene

  • May promote cancer cell proliferation by controlling the G1 to S phase transition.

Additional gene information for C1orf109 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1orf109 Gene

Genomics for C1orf109 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1orf109 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J037688 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 631.4 +0.9 892 5.5 SP1 HNRNPL CREB1 CTCF PRDM10 ZNF629 SIX5 IKZF1 NFKBIZ ZNF692 C1orf109 CDCA8 lnc-C1orf109-1 EPHA10 SF3A3 GNL2 FTH1P1 RSPO1 YRDC DNALI1
GH01J037988 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 85.8 -297.4 -297358 2.6 ZNF221 BRCA1 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 REST SF3A3 RF00026-026 RNU6-510P C1orf109 INPP5B GNL2 FHL3 MYCBP FTH1P1 RSPO1
GH01J037552 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 51.4 +138.4 138435 2.2 SP1 CREB1 ZNF629 TFE3 ZNF512 SIX5 LEF1 IKZF1 KDM1A ZNF692 SNIP1 lnc-GNL2-2 C1orf109 SF3A3 GNL2 FTH1P1 INPP5B CDCA8 YRDC ZC3H12A
GH01J038008 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 24.9 -320.6 -320574 9.3 RNF2 SP1 HNRNPL CREB1 GATAD2A ZBTB33 PRDM10 REST ZNF629 TFE3 UTP11 INPP5B SF3A3 C1orf109 SNIP1 CDCA8 RNU6-510P FTH1P1 RSPO1 MTF1
GH01J037930 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 28.6 -239.4 -239379 3.2 SP1 HNRNPL CREB1 TEAD4 RFX1 KDM1A BACH1 FOS JUND DDX20 LOC105378651 SF3A3 C1orf109 SNIP1 GNL2 FHL3 UTP11 INPP5B HSALNG0002670 MTF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf109 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1orf109

Top Transcription factor binding sites by QIAGEN in the C1orf109 gene promoter:
  • AML1a
  • AREB6
  • Nkx2-2
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)

Genomic Locations for C1orf109 Gene

Genomic Locations for C1orf109 Gene
chr1:37,681,570-37,692,336
(GRCh38/hg38)
Size:
10,767 bases
Orientation:
Minus strand
chr1:38,147,242-38,157,914
(GRCh37/hg19)
Size:
10,673 bases
Orientation:
Minus strand

Genomic View for C1orf109 Gene

Genes around C1orf109 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf109 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf109 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf109 Gene

Proteins for C1orf109 Gene

  • Protein details for C1orf109 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX04-CA109_HUMAN
    Recommended name:
    Uncharacterized protein C1orf109
    Protein Accession:
    Q9NX04
    Secondary Accessions:
    • D3DPT1
    • Q8WVD1

    Protein attributes for C1orf109 Gene

    Size:
    203 amino acids
    Molecular mass:
    23373 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf109 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf109 Gene

Post-translational modifications for C1orf109 Gene

No data available for DME Specific Peptides for C1orf109 Gene

Domains & Families for C1orf109 Gene

Gene Families for C1orf109 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf109 Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
ProtoNet:
genes like me logo Genes that share domains with C1orf109: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1orf109 Gene

Function for C1orf109 Gene

Molecular function for C1orf109 Gene

UniProtKB/Swiss-Prot Function:
May promote cancer cell proliferation by controlling the G1 to S phase transition.

Phenotypes From GWAS Catalog for C1orf109 Gene

Gene Ontology (GO) - Molecular Function for C1orf109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with C1orf109: view
genes like me logo Genes that share phenotypes with C1orf109: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf109

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf109 Gene

Localization for C1orf109 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf109 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf109 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22548824
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 22548824
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C1orf109: view

Pathways & Interactions for C1orf109 Gene

PathCards logo

SuperPathways for C1orf109 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf109 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf109 Gene

Drugs & Compounds for C1orf109 Gene

No Compound Related Data Available

Transcripts for C1orf109 Gene

mRNA/cDNA for C1orf109 Gene

20 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1orf109

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf109 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - -
SP13: - -
SP14: -
SP15:
SP16: - -
SP17: -

ExUns: 8c ^ 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for C1orf109 Gene

GeneLoc Exon Structure for
C1orf109

Expression for C1orf109 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf109 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1orf109 Gene

This gene is overexpressed in Fetal ovary (24.5) and Plasma (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf109 Gene



Protein tissue co-expression partners for C1orf109 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1orf109

SOURCE GeneReport for Unigene cluster for C1orf109 Gene:

Hs.272673

Evidence on tissue expression from TISSUES for C1orf109 Gene

  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with C1orf109: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf109 Gene

Orthologs for C1orf109 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf109 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C1orf109 31
  • 99 (a)
OneToOne
C1H1orf109 30
  • 98.85 (n)
Cow
(Bos Taurus)
Mammalia C3H1orf109 30
  • 87.85 (n)
MGC166151 31
  • 86 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C15H1orf109 30
  • 83.42 (n)
C1orf109 31
  • 78 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 9930104L06Rik 30 17
  • 80.95 (n)
Rat
(Rattus norvegicus)
Mammalia RGD1560436 30
  • 80.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia C1orf109 31
  • 69 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C1orf109 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C1ORF109 30
  • 54.02 (n)
C1orf109 31
  • 37 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C1orf109 31
  • 43 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c1orf109 30
  • 55.72 (n)
Zebrafish
(Danio rerio)
Actinopterygii c1orf109 30
  • 49.74 (n)
C19H1orf109 31
  • 37 (a)
OneToOne
Species where no ortholog for C1orf109 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C1orf109 Gene

ENSEMBL:
Gene Tree for C1orf109 (if available)
TreeFam:
Gene Tree for C1orf109 (if available)

Paralogs for C1orf109 Gene

No data available for Paralogs for C1orf109 Gene

Variants for C1orf109 Gene

Additional dbSNP identifiers (rs#s) for C1orf109 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1orf109 Gene

Variant ID Type Subtype PubMed ID
nsv819737 CNV loss 19587683
nsv834746 CNV loss 17160897

Variation tolerance for C1orf109 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf109 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf109

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1orf109 Gene

Disorders for C1orf109 Gene

No disorders were found for C1orf109 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf109 Gene

Publications for C1orf109 Gene

  1. Identification and characterization of a novel gene, c1orf109, encoding a CK2 substrate that is involved in cancer cell proliferation. (PMID: 22548824) Liu SS … Li Y (Journal of biomedical science 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. (PMID: 30232004) Abraham CG … Espinosa JM (Cell reports 2018) 3

Products for C1orf109 Gene

Sources for C1orf109 Gene