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Aliases for C1orf105 Gene

Aliases for C1orf105 Gene

  • Chromosome 1 Open Reading Frame 105 2 3 5
  • Uncharacterized Protein C1orf105 3

External Ids for C1orf105 Gene

Previous GeneCards Identifiers for C1orf105 Gene

  • GC01P169122
  • GC01P170656
  • GC01P143613

Summaries for C1orf105 Gene

GeneCards Summary for C1orf105 Gene

C1orf105 (Chromosome 1 Open Reading Frame 105) is a Protein Coding gene. Diseases associated with C1orf105 include Glycosylphosphatidylinositol Biosynthesis Defect 16.

Additional gene information for C1orf105 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf105 Gene

Genomics for C1orf105 Gene

GeneHancer (GH) Regulatory Elements for C1orf105 Gene

Promoters and enhancers for C1orf105 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J172420 Promoter 0.5 EPDnew 650.7 +0.2 167 0.1 C1orf105 PIGC LOC102724528
GH01J172448 Enhancer 1.4 Ensembl ENCODE dbSUPER 31.2 +30.8 30756 6.4 PKNOX1 CLOCK FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 PIGC C1orf105 SUCO PRRC2C METTL13 LOC102724528
GH01J172475 Enhancer 0.9 ENCODE dbSUPER 27 +57.5 57517 5.5 MEIS2 LEF1 CEBPG FEZF1 MCM2 IRF9 CC2D1A ZFHX2 GATA3 ZSCAN29 C1orf105 PIGC SUCO METTL13 LOC102724528
GH01J172389 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -24.0 -23959 13.8 PKNOX1 FOXA2 SIN3A IRF4 YY1 TCF12 ZNF143 ATF7 FOS RUNX3 PIGC RNU6-157P C1orf105 LOC102724528 DNM3
GH01J172353 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -62.5 -62538 8.2 PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 IRF4 PIGC PRRC2C ENSG00000253060 LOC391136 LOC100422549 METTL13 C1orf105 GC01P172366 PIR59615 DNM3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1orf105 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf105 gene promoter:

Genomic Locations for C1orf105 Gene

Genomic Locations for C1orf105 Gene
chr1:172,420,515-172,468,831
(GRCh38/hg38)
Size:
48,317 bases
Orientation:
Plus strand
chr1:172,389,828-172,437,971
(GRCh37/hg19)

Genomic View for C1orf105 Gene

Genes around C1orf105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf105 Gene

Proteins for C1orf105 Gene

  • Protein details for C1orf105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95561-CA105_HUMAN
    Recommended name:
    Uncharacterized protein C1orf105
    Protein Accession:
    O95561
    Secondary Accessions:
    • Q8IY02

    Protein attributes for C1orf105 Gene

    Size:
    183 amino acids
    Molecular mass:
    21209 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf105 Gene

Post-translational modifications for C1orf105 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1orf105 Gene

Domains & Families for C1orf105 Gene

Gene Families for C1orf105 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf105 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf105 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf105: view

No data available for UniProtKB/Swiss-Prot for C1orf105 Gene

Function for C1orf105 Gene

Phenotypes From GWAS Catalog for C1orf105 Gene

Gene Ontology (GO) - Molecular Function for C1orf105 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C1orf105: view
genes like me logo Genes that share phenotypes with C1orf105: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf105 Gene

Localization for C1orf105 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf105 gene
Compartment Confidence
nucleus 2
extracellular 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C1orf105 Gene

Pathways & Interactions for C1orf105 Gene

SuperPathways for C1orf105 Gene

No Data Available

Interacting Proteins for C1orf105 Gene

Gene Ontology (GO) - Biological Process for C1orf105 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf105 Gene

Drugs & Compounds for C1orf105 Gene

No Compound Related Data Available

Transcripts for C1orf105 Gene

mRNA/cDNA for C1orf105 Gene

Unigene Clusters for C1orf105 Gene

Chromosome 1 open reading frame 105:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf105 Gene

No ASD Table

Relevant External Links for C1orf105 Gene

GeneLoc Exon Structure for
C1orf105
ECgene alternative splicing isoforms for
C1orf105

Expression for C1orf105 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf105 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf105 Gene

This gene is overexpressed in Testis (x19.7), Heart - Left Ventricle (x14.4), and Heart - Atrial Appendage (x14.1).

Protein differential expression in normal tissues from HIPED for C1orf105 Gene

This gene is overexpressed in Heart (39.7), Adrenal (12.0), Frontal cortex (11.1), and Fetal heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf105 Gene



Protein tissue co-expression partners for C1orf105 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf105 Gene:

C1orf105

SOURCE GeneReport for Unigene cluster for C1orf105 Gene:

Hs.517991
genes like me logo Genes that share expression patterns with C1orf105: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf105 Gene

Orthologs for C1orf105 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf105 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf105 33
  • 98.91 (n)
C1orf105 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf105 33
  • 84.88 (n)
-- 34
  • 80 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C16H1orf105 33
  • 83.06 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309106 33
  • 75 (n)
mouse
(Mus musculus)
Mammalia 4930558K02Rik 16 34 33
  • 72.1 (n)
Species where no ortholog for C1orf105 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf105 Gene

ENSEMBL:
Gene Tree for C1orf105 (if available)
TreeFam:
Gene Tree for C1orf105 (if available)

Paralogs for C1orf105 Gene

No data available for Paralogs for C1orf105 Gene

Variants for C1orf105 Gene

Sequence variations from dbSNP and Humsavar for C1orf105 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs115209243 pathogenic, GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 16 172,442,562(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs786205667 likely-pathogenic, Non-immune hydrops fetalis 172,441,964(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000025899 -- 172,430,239(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000046711 -- 172,448,156(+) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000116275 -- 172,421,142(+) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf105 Gene

Variant ID Type Subtype PubMed ID
esv2669467 CNV deletion 23128226
esv3587924 CNV loss 21293372
nsv947449 CNV duplication 23825009

Variation tolerance for C1orf105 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf105 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf105

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf105 Gene

Disorders for C1orf105 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1orf105 Gene - From: GeneCards

Disorder Aliases PubMed IDs
glycosylphosphatidylinositol biosynthesis defect 16
  • gpibd16
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C1orf105

genes like me logo Genes that share disorders with C1orf105: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf105 Gene

Publications for C1orf105 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for C1orf105 Gene

Sources for C1orf105 Gene

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